Robust eco-friendly protocol for the preparation of γ-hydroxy-α,β-acetylenic esters by sequential one-pot elimination–addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF

2-Methyltetrahydrofuran: A Versatile Eco-Friendly Alternative to THF in Organometallic Chemistry

(2012) Vittorio Pace   AUSTRALIAN JOURNAL OF CHEMISTRY

2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry

(2012) Vittorio Pace et al.   ChemSusChem

Gold(I)-Catalyzed Tandem Alkoxylation/Lactonization of γ-Hydroxy-α,β-Acetylenic Esters

(2011) Rubén S. Ramón et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis and First Biological Evaluation of an Iron-Containing HETE Analogue

(2011) Nina Kausch-Busies et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Versatile Zirconium Reductants and Carbon-Carbon Coupling Agents Selectively Accessible from the 2:1 Molar Aggregate of n-Butyllithium and Zirconium(IV) Salts

(2011) John J. Eisch et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Highly efficient chemoselective N-TBS protection of anilines under exceptional mild conditions in the eco-friendly solvent 2-methyltetrahydrofuran

(2011) Vittorio Pace et al.   GREEN CHEMISTRY

Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

(2011) Richard K. Henderson et al.   GREEN CHEMISTRY

Optimised Dynamic Kinetic Resolution of benzoin by a chemoenzymatic approach in 2-MeTHF

(2011) Pilar Hoyos et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any additives

(2011) Naoto Kojima et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of NP25302

(2011) Kiri Stevens et al.   ORGANIC LETTERS

Toxicological Assessment of 2-Methyltetrahydrofuran and Cyclopentyl Methyl Ether in Support of Their Use in Pharmaceutical Chemical Process Development

(2011) Vincent Antonucci et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A new flexible strategy for the synthesis of gem-difluoro-bisarylic derivatives and heterocyclic analogues

(2011) Ali Khalaf et al.   TETRAHEDRON

Highly regioselective control of 1,2-addition of organolithiums to α,β-unsaturated compounds promoted by lithium bromide in 2-methyltetrahydrofuran: a facile and eco-friendly access to allylic alcohols and amines

(2011) Vittorio Pace et al.   TETRAHEDRON

Chiral phosphine–phosphite ligands in the enantioselective 1,4-addition of Grignard reagents to α,β-unsaturated carbonyl compounds

(2011) Qaseem Naeemi et al.   TETRAHEDRON-ASYMMETRY

Total Synthesis of the Marine Antibiotic Pestalone and its Surprisingly Facile Conversion into Pestalalactone and Pestalachloride A

(2010) Nikolay Slavov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-catalyzed C–C bond formation using 2-methyltetrahydrofuran (2-MTHF) as (co)solvent: efficient and bio-based alternative to DMSO and MTBE

(2010) Saravanakumar Shanmuganathan et al.   GREEN CHEMISTRY

2-Methyltetrahydrofuran as a suitable green solvent for phthalimide functionalization promoted by supported KF

(2010) Vittorio Pace et al.   GREEN CHEMISTRY

Improved Arndt−Eistert Synthesis of α-Diazoketones Requiring Minimal Diazomethane in the Presence of Calcium Oxide as Acid Scavenger

(2010) Vittorio Pace et al.   JOURNAL OF ORGANIC CHEMISTRY

γ-Hydroxy-α,β-acetylenic esters: asymmetric syntheses and applications

(2010) Ge Gao et al.   Science China-Chemistry

Synthesis of a C1 symmetric BINOL–terpyridine ligand and highly enantioselective methyl propiolate addition to aromatic aldehydes

(2010) Xi Chen et al.   TETRAHEDRON

Silica-immobilized piperazine: A sustainable organocatalyst for aldol and Knoevenagel reactions

(2010) Saravanakumar Shanmuganathan et al.   TETRAHEDRON LETTERS

Highly enantioselective addition of methyl propiolate to aldehydes catalyzed by a titanium(IV) complex of a β-hydroxy amide

(2010) Tao Xu et al.   TETRAHEDRON-ASYMMETRY

The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups

(2009) Barry M. Trost et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Efficient Synthesis of New α-Arylamino-α′-chloropropan-2-ones via Oxidative Hydrolysis of Vinyl Chlorides Promoted by Calcium Hypochlorite

(2009) Vittorio Pace et al.   ADVANCED SYNTHESIS & CATALYSIS

Acetylides from Alkyl Propiolates as Building Blocks for C3Homologation

(2009) David Tejedor et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

Base-Catalyzed Highly Stereoselective Conversion of γ-Hydroxy-α,β-acetylenic Esters to γ-Acetoxy Dienoates

(2009) Yang Yue et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regioselective enzymatic acylation of pharmacologically interesting nucleosides in 2-methyltetrahydrofuran, a greener substitute for THF

(2009) Yolanda Simeó et al.   GREEN CHEMISTRY

Reactivity of γ-Hydroxy-α,β-acetylenic Esters with Amines: Facile Synthesis of the Optically Active 4-Amino-2(5H)-furanones

(2009) Li-Hong Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Horner–Wadsworth–Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones

(2009) Vittorio Pace et al.   TETRAHEDRON LETTERS

Enantioselective Cu-Catalyzed 1,4-Addition of Grignard Reagents to Cyclohexenone Using Taddol-Derived Phosphine-Phosphite Ligands and 2-Methyl-THF as a Solvent

(2008) Tobias Robert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION