Journal
GREEN CHEMISTRY
Volume 14, Issue 10, Pages 2672-2676Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2gc35713e
Keywords
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Funding
- University of California (UC)
- UC Regents Faculty Fellowship
- Cancer Research Coordinating Committee Grant
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A high-yielding three-component reaction proceeds under mild, solvent-free conditions for access to a wide variety of fully-substituted propargylamines. Inexpensive copper(II) chloride catalyzes the coupling of equimolar amounts of amines, alkynes, and cyclohexanone such that the only by-product is one equivalent of water.
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