Journal
GREEN CHEMISTRY
Volume 13, Issue 5, Pages 1217-1223Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0gc00899k
Keywords
-
Ask authors/readers for more resources
A highly green and expeditious route to alpha-mercapto-gamma-lactams from masked mercapto acids viz. 2-phenyl-2-methyl-1,3-oxathiolan-5-ones, and tosyl aziridines in an excellent yield (82-93%) is reported. The synthetic protocol involves regioselective opening of the terminal aziridine ring and mercaptoacetylative cyclisation cascades in a one-pot procedure wherein water acts as both a catalyst as well as a solvent. These reactions were carried out in aqueous media as well as under solvent-free conditions, however, under solvent-free conditions, lower yields are obtained.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available