Journal
GREEN CHEMISTRY
Volume 13, Issue 9, Pages 2553-2560Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1gc15416h
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Funding
- National Institute of Pharmaceutical Education and Research (NIPER)
- Council of Scientific and Industrial Research (CSIR), Government of India
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A mild and eco-friendly method has been developed for aminolysis of 3-oxirane-indolin-2-ones with aliphatic and aromatic amines to afford 3-hydroxy-3-aminomethylindolin-2-ones. An enhancement in reaction rate was observed when water was used as the reaction medium. The reactions proceed regiospecifically to open the epoxide ring from the less-substituted end.
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