Article
Chemistry, Physical
Jiangtao Peng, Ruifeng Guo, Xiongxi Shi, Peiping Zhang, Fagui Qiu, Wenqing Li, Cundi Wei, Shiding Miao
Summary: A new type of clay-supported catalyst has been developed for the cycloaddition of CO2 using metal-free ionic liquids immobilized on ball clay. The catalyst demonstrates excellent performance and suitability for the reaction.
APPLIED CLAY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Palkowski, Maciej Karolak, Andrzej Skrzypczak, Marta Wojcieszak, Filip Walkiewicz, Jonasz Podemski, Karol Jaroch, Barbara Bojko, Katarzyna Materna, Jerzy Krysinski
Summary: This study synthesized a series of novel quaternary imidazolium derivatives with ionic liquid properties, and tested their antimicrobial activity, cytotoxicity, and surface properties. The results showed that all synthesized compounds exhibited antimicrobial and cytotoxic activity, making them potential candidates for new antimicrobial agents or surfactants.
Review
Biochemistry & Molecular Biology
Ana R. P. Goncalves, Xavier Paredes, A. F. Cristino, F. J. V. Santos, Carla S. G. P. Queiros
Summary: Ionic liquids were initially touted as environmentally friendly replacements for traditional solvents, but research on their interactions with organisms is lacking. Lipophilicity and the type of cation play key roles in toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agricultural Engineering
Janusz Nowicki, Natalia Stanek
Summary: This study demonstrates that the conversion of carbohydrates (glucose, xylose, fructose) to furan aldehydes is significantly influenced by the structural parameters of the ionic liquid catalyst and the presence of a Bronsted acid co-catalyst. The synergistic effect of acidic IL and Bronsted acid plays a crucial role in enhancing the selectivity and efficiency of the conversion process.
BIOMASS & BIOENERGY
(2021)
Article
Chemistry, Multidisciplinary
Yuval Simha, Gil Daniels, Amalya Goldman, Elihay Kuniavsky, Dmitry Tsvelikhovsky
Summary: A new strategy for direct access to fully substituted polycyclic imidazolium salts using alpha-enaminones and proline as the reagents is reported. This open-flask operation is a catalyst-, metal-, and Lewis acid-free green process, which does not require an ion-exchange step. It can produce good yields with minimal formation of side products, and is not limited to aryl substituents.
Article
Engineering, Environmental
Tian-Lin Ren, Xi-Wen Ma, Xiao-Qiong Wu, Li Yuan, Yang-Li Lai, Zhong-Hua Tong
Summary: Thermally activated persulfate oxidation was used for the degradation of ionic liquids, showing effective removal of ILs. Factors affecting the degradation included temperature, PS concentration, solution pH, and alkyl chain length, while intermediate products and degradation mechanism were identified. Free radicals generated in the activated PS system had different effects on degradation, with SO4?? radicals attacking the side chain and ?OH attacking the core, offering a potential environmentally friendly approach for ILs treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Briana R. Schrage, Baosen Zhang, Stephen C. Petrochko, Zhiling Zhao, Ariana Frkonja-Kuczin, Aliaksei Boika, Christopher J. Ziegler
Summary: A series of highly soluble catholytes were synthesized for RFB applications, but the increasing viscosity of the solutions with longer imidazolium chain lengths limits their applicability in RFB design.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Lili Jiang, Ke Mei, Kaihong Chen, Rina Dao, Haoran Li, Congmin Wang
Summary: An efficient method for predicting the capture of SO2 from flue gas using imidazolium ionic liquids was reported. Through quantitative calculations and design, the absorption performance of various imidazolium ionic liquids for SO2 was predicted and validated through experiments.
GREEN ENERGY & ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Pandurangan Ganapathi, Kilivelu Ganesan, Mahendiran Dharmasivam, Mohammed Mujahid Alam, Amanullah Mohammed
Summary: This study reports a method for synthesizing dimeric nitro-substituted imidazolium salts, which is solvent-free and has many advantages. The research found that these compounds showed excellent inhibition against E. coli and P. aeruginosa bacteria and this was further supported by molecular docking studies.
Article
Biochemistry & Molecular Biology
Luis Guzman, Cristobal Parra-Cid, Etiennette Guerrero-Munoz, Carlos Pena-Varas, Efrain Polo-Cuadrado, Yorley Duarte, Ricardo I. Castro, Luz Stella Nerio, Ramiro Araya-Maturana, Tewodros Asefa, Javier Echeverria, David Ramirez, Oscar Forero-Doria
Summary: This study evaluated the antimicrobial properties of different ILs, finding that some exhibit good antibacterial activity against S. aureus, E. coli, and P. aeruginosa. Particularly, tert-butyl N-methylphenolimidazolium salts showed the best antibacterial efficacy. Furthermore, the antimicrobial effectiveness was found to be influenced by the alkyl chain length and substituents on the phenolic ring.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Trupti C. Nirmale, Nageshwar D. Khupse, Ramchandra S. Kalubarme, Milind Kulkarni, Anjani J. Varma, Bharat B. Kale
Summary: Ionic liquids as next-generation electrolytes have high ionic conductivity and electrochemical stability at high temperatures. Subtle structural changes can improve diffusion and enhance cyclability and performance.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Engineering, Environmental
Nuzahat Habibul, Yan-Yun Hu, Yi Hu, Guo-Ping Sheng
Summary: This study investigated the uptake and toxicity of imidazolium based ionic liquids (ILs) with different alkyl chain lengths by ryegrass. Results showed that long alkyl chain ILs had stronger growth inhibition on plants compared to short chain ILs, which were more easily absorbed and accumulated in plant tissues.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Leonhard Winter, Radha G. Bhuin, Florian Maier, Hans-Peter Steinrueck
Summary: This study explores the interaction of molecules at the gas/ionic liquid surface and investigates the dynamics of this process through measuring the trapping probabilities of gases on IL surfaces. The results show that desorption energy increases with longer alkyl chain length and smaller anion size, while the adsorption energy is dependent on the properties of the adsorbing molecules.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Raul Porcar, Eduardo Garcia-Verdugo, Belen Altava, Maria Isabel Burguete, Santiago V. Luis
Summary: Chiral imidazolium l-prolinate salts have been studied as green and efficient chiral organocatalysts for direct asymmetric aldol reactions at room temperature. The presence of chirality in both the imidazolium cation and prolinate anion plays a significant role in transferring chirality from the organocatalyst to the aldol product. By selecting proper structural elements in the cation and anion, excellent activities, selectivities, and enantioselectivities can be achieved.
Article
Chemistry, Physical
Lili Deng, Qian Su, Xin Tan, Yichao Wang, Li Dong, Hongyan He, Zengxi Li, Weiguo Cheng
Summary: The synthesis of cyclic carbonates from cheap and reusable urea using efficient catalysts is important. In this study, eco-friendly ionic liquids (ILs) were used as catalysts, and by regulating the cation chain lengths, different lewis acid centers were constructed. The IL with a moderate side chain showed better catalytic performance and the yield of ethylene carbonate could reach 96%.
MOLECULAR CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Jaan Parve, Marina Kudryasova, Tatsiana Shalima, Ly Villo, Ilme Liblikas, Indrek Reile, Tonis Pehk, Nicholas Gathergood, Riina Aav, Lauri Vares, Omar Parve
Summary: The study presents a simple synthesis method for 4-(acyloxy)pentanoic acids from gamma-valerolactone, producing high enantiomeric excess products that stimulate the development of novel applications, including biobased isotactic polymers.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Environmental Sciences
Sivakumar Uthandi, Ashokkumar Kaliyaperumal, Naganandhini Srinivasan, Kiruthika Thangavelu, Iniya Kumar Muniraj, Xinmin Zhan, Nicholas Gathergood, Vijai Kumar Gupta
Summary: Microbial oils offer a potential solution for biodiesel production, with oleaginous microorganisms accumulating high levels of oils in their cells. Using lignocellulosic biomass as a renewable raw material for producing second-generation biodiesel has become a fundamental approach for tackling challenges of higher energy costs, environmental protection, and depletion of crude oil reserves. Research is focused on examining different microbes' lipid accumulation capability using lignocellulosic biomass as substrates and overcoming future challenges in using lignocellulosic biomass for biodiesel production.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Claire Fergus, Mashael Al-Qasem, Michelle Cotter, Ciara M. McDonnell, Emiliano Sorrentino, Franciane Chevot, Karsten Hokamp, Mathias O. Senge, John M. Southern, Stephen J. Connon, Vincent P. Kelly
Summary: Base modification can occur throughout a transfer RNA molecule, with a particular emphasis on position 34 of the anticodon loop. Human enzymes can recognize a wide range of artificial derivatives for transfer RNA incorporation, while displaying strict specificity for decoding certain codons. Exploiting the queuosine incorporation pathway shows broad potential for intentionally engineering chemical diversity into transfer RNA anticodons.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dewi K. A. Kusumahastuti, Mariliis Sihtmae, Villem Aruoja, Nicholas Gathergood, Anne Kahru
Summary: The study evaluated the ecotoxicity of 24 L-phenylalanine derived surface-active ionic liquids. Only two of the studied SAILs were considered to have low toxicity, while the aquatic crustaceans were found to be about 100 times more tolerant to the SAILs compared to algae. An alternative classification scale based on the average molecular weight of the compounds was suggested for ranking the compounds and suggesting greener alternatives for commercial SAILs/surfactants.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Chemistry, Organic
Mili Litvajova, Emiliano Sorrentino, Brendan Twamley, Stephen J. Connon
Summary: This study demonstrates the application of N-protected oxindole derivatives with unprecedented malleability in enantioselective phase-transfer-catalysed alkylations. By optimizing the structure of the catalyst, high levels of enantioselectivity were achieved. It was found that urea-based catalysts outperformed squaramide derivatives, and that installing a chlorine atom in the quinoline moiety of the catalyst improved reaction selectivity.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Negar Maafi, Filip Pidany, Jana Marikova, Jan Korabecny, Daniela Hulcova, Tomas Kucera, Monika Schmidt, Latifah Al Shammari, Marcel Spulak, Maria Carmen Catapano, Marko Mecava, Lukas Prchald, Jiri Kunes, Jiri Janousek, Eliska Kohelova, Jaroslav Jenco, Lucie Novakova, Lucie Cahlikova
Summary: A total of twenty-eight new derivatives of montanine-type Amaryllidaceae alkaloids were synthesized and evaluated for their inhibitory effects on acetylcholinesterase and butyrylcholinesterase. Three derivatives showed significant selective inhibitory potency for acetylcholinesterase, while one analog demonstrated selective inhibition activity for butyrylcholinesterase. Predictions suggest that these active compounds should be able to pass through the blood-brain barrier.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Organic
Simon N. Smith, Stephen J. Connon
Summary: The ring contraction-lactamisation of anhydrides with trimethylsilylazide in the presence of an amine catalyst has been studied. It is possible to generate 5,- 6- and 8-membered ring lactams from cyclic anhydrides under controlled conditions, with a simple operation procedure. Succinic anhydrides can be used to produce N-carboxyanhydrides for polymer chemistry and as beta-peptide precursors.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Cristina Trujillo, Sarah A. Cronin, Stephen J. Connon
Summary: A complete computational study was conducted to rationalize a new organocatalytic approach for the kinetic resolution of 4-substituted oxazinones, resulting in highly enantioenriched beta-amino acids. The study also investigated the alcoholytic kinetic resolution of a 7-memebered ring analogue for the first time, generating enantioenriched gamma-amino acids.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Editorial Material
Chemistry, Multidisciplinary
David T. Allen, Peter Licence, Bala Subramaniam, Paul T. Anastas, D. Julie Carrier, Jingwen Chen, Nicholas Gathergood, Jeannette M. Garcia, Jinlong Gong, Hongxian Han, King Kuok (Mimi) Hii, Bing-Joe Hwang, Andrew Marr, Michael Meier, Audrey Moores, Ryuhei Nakamura, Thalappil Pradeep, Liane Rossi, Bert Sels, Michael K. C. Tam, Lin Zhuang, Julio F. Serrano
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Editorial Material
Chemistry, Multidisciplinary
David T. Allen, D. Julie Carrier, Jingwen Chen, Nicholas Gathergood, Jeannette M. Garcia, Jinlong Gong, Hongxian Han, King Kuok (Mimi) Hii, Bing-Joe Hwang, Asha Liza James, Mihir Jha, Peter Licence, Andrew C. Marr, Michael Meier, Audrey Moores, Ryuhei Nakamura, Thalappil Pradeep, Liane Rossi, Bert Sels, Bala Subramaniam, Michael K. C. Tam, Lin Zhuang, Julio F. Serrano
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Medicinal
Ciara M. McDonnell, Magda Ghanim, J. Mike Southern, Vincent P. Kelly, Stephen J. Connon
Summary: This study investigates the impact of modified beta-lysines on the growth rates of eubacterial cells. The results indicate that the observed effects are due to the post translational modification of Elongation Factor P (EFP) catalyzed by PoxA. The promiscuity of PoxA allows for examination of a wide range of exogenous beta-lysines.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Illia V. Kapitanov, Grete Raba, Marcel Spulak, Raivo Vilu, Yevgen Karpichev, Nicholas Gathergood
Summary: A series of dipeptide ionic liquids (ILs) containing L-phenylalanine and L-alanine fragments were synthesized and their possible degradation pathways were analyzed. The compounds were screened for microbial toxicity and aerobic biodegradation, and the results showed that L-phenylalanine derivatives had higher biodegradability compared to L-alanine derivatives.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Illia V. V. Kapitanov, Surya M. M. Sudheer, Toshikee Yadav, Kallol K. K. Ghosh, Nicholas Gathergood, Vijai K. K. Gupta, Yevgen Karpichev
Summary: The solubilization capacity of sustainable phenylalanine-derived surface-active ionic liquids (SAILs) towards polycyclic aromatic hydrocarbons (PAHs) was evaluated and compared with a conventional cationic surfactant, CTABr. The SAILs showed increased solubilization capacity with longer alkyl chain length, comparable to CTABr for certain SAIL types. The phenylalanine-derived SAILs also had the advantage of enzymatically cleaving ester and amide bonds under mild conditions for in situ separation of PAHs.
Article
Chemistry, Organic
Sarah A. Cronin, Stephen J. Connon
Summary: This study introduces a novel approach to catalytic, alcoholytic kinetic resolution of oxazinones using a stereochemically dense cinchona alkaloid-based catalyst. The catalyst enables highly enantiodiscriminatory ring-opening of oxazinones equipped with electrophilic aryl units, leading to the generation of orthogonally protected beta-amino acids for the first time.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Eoghan G. Delany, Stephen J. Connon
Summary: The enantioselective intermolecular crossed-benzoin condensation mediated by novel chiral N-heterocyclic carbenes derived from pyroglutamic acid has been investigated. Increasing both the steric requirement and the electron-withdrawing characteristics of the N-aryl ring led to more chemoselective, efficient and enantioselective chemistry. Subsequent protocol optimization involving o-substituted benzaldehyde as one reacting partner allowed a range of crossed-benzoins to be synthesized in moderate-good yields with moderate to excellent enantioselectivity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.
