4.8 Article

Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

Journal

GREEN CHEMISTRY
Volume 11, Issue 6, Pages 760-762

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b902025j

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Funding

  1. National Nature Science Foundation of China [20772024, 20802016]

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Novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides were prepared in one step by nucleophilic substitution reaction of 6-choloropurine nucleosides with diethanolamine. Shorter reaction times and higher yields were achieved under microwave irradiation conditions in neat water.

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