Journal
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Volume 252, Issue 12, Pages 1993-1997Publisher
SPRINGER
DOI: 10.1007/s00417-014-2784-2
Keywords
Animal model; Endophthalmitis; Ocular penetration; Pharmacokinetics; Tigecycline
Categories
Funding
- Konya Training and Research Hospital (KTRH-28), Konya, Turkey
Ask authors/readers for more resources
The purpose of this study was to evaluate the ocular distribution of intravenously administered tigecycline in a rabbit uveitis model. Tigecycline, which has a broad spectrum of activity against many gram-positive, gram-negative, and anaerobic organisms, was given intravenously to rabbits at 7 mg/kg of body weight starting 24 h after induction of uveitis by intravitreal endotoxin injection. Tigecycline concentrations were determined by high performance liquid chromatography-mass spectrometry (LC-MS/MS) assay in the aqueous humor, vitreous humor, and plasma 1, 3, 6, and 24 h after administration of a single dose. The maximum concentrations were found within 1 h after the end of the intravenously given tigecycline, and were 1,308.60 +/- 301.76 ng/mL in plasma, 181.40 +/- 51.32 ng/mL in vitreous humor and 145.00 +/- 55.29 ng/mL in aqueous humor of the inflamed eye. After 24 h, no drug was detectable in the aqueous and vitreous of the normal eyes, whereas small amounts of drug were detectable in inflamed eyes and in plasma. Tigecycline did not reach therapeutically significant levels in the aqueous and the vitreous humor of rabbit eyes. The findings suggest a limited role for intravenously administered tigecycline in the treatment of bacterial endophthalmitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available