Article
Neurosciences
Priyamvada M. Pitale, Guofu Shen, Rohini R. Sigireddi, Maria Polo-Prieto, Yong H. Park, Solomon E. Gibson, Peter D. Westenskow, Roomasa Channa, Benjamin J. Frankfort
Summary: The study revealed vascular damage in mice exposed to mild levels of induced ocular hypertension, potentially caused by abnormalities in the intermediate retinal capillary plexus (IRCP). This IRCP-specific phenotype precedes RGC loss, suggesting a possible mechanistic link for early vascular remodeling in glaucoma.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Jose A. Fernandez-Albarral, Miguel A. Martinez-Lopez, Eva M. Marco, Rosa de Hoz, Beatriz Martin-Sanchez, Diego San Felipe, Elena Salobrar-Garcia, Ines Lopez-Cuenca, Maria D. Pinazo-Duran, Juan J. Salazar, Jose M. Ramirez, Meritxell Lopez-Gallardo, Ana I. Ramirez
Summary: The study analyzed the anti-inflammatory effect of a saffron extract on regulating the production of cytokines and chemokines in a mouse model of glaucoma, showing promising results for reducing inflammation and protecting retinal health.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
James R. Tribble, Amin Otmani, Eirini Kokkali, Emma Lardner, James E. Morgan, Pete A. Williams
Summary: An inducible, magnetic bead model in Brown Norway rats was developed to replicate glaucoma features in human eyes. The model successfully demonstrated degeneration across multiple retinal ganglion cell compartments, providing a platform for testing glaucoma therapeutics.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maoren Wang, Hanhan Liu, Ning Xia, Huige Li, Tim van Beers, Adrian Gericke, Verena Prokosch
Summary: Research on vascular abnormalities in glaucoma pathogenesis has produced controversial conclusions. This study found that elevated intraocular pressure can induce persistent endothelial dysfunction in retinal arterioles and contribute to retinal ganglion cell loss. Factors such as oxidative stress, inflammation, and loss of pericytes may play a role in triggering vascular functional deficits even after intraocular pressure normalization.
Article
Ophthalmology
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Mariam Adeleke, Victoria Vickerstaff, Gareth Ambler, Rachael Hunter, Catey Bunce, Neil Nathwani, Keith Barton, The LiGHT Trial Study Grp
Summary: After 6 years of treatment, selective laser trabeculoplasty (SLT) has been shown to be a more effective and cost-effective primary treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT) compared to intraocular pressure (IOP)-lowering eye drops. The SLT group had better glaucoma symptom scores and 69.8% of eyes in this group achieved or maintained the target IOP without the need for medical or surgical treatment.
Review
Biochemistry & Molecular Biology
Nasir Uddin, Matt Rutar
Summary: Clearance of ocular fluid and metabolic waste is crucial for the eye's health. While the anterior outflow pathway is well understood, less is known about the posterior outflow routes. Recent studies suggest that lymphatic and glymphatic systems play an important role in clearing fluid and waste from the posterior segment of the eye.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jiexuan Lv, Ruxin Gao, Yao Wang, Changquan Huang, Renyi Wu
Summary: Glaucoma is a leading cause of irreversible blindness worldwide. Leukemia inhibitory factor (LIF), a member of the IL-6 cytokine family, has been shown to have neuroprotective effects in acute ocular hypertension (AOH). The present study found that LIF treatment inhibited retinal damage induced by AOH and reduced RGC loss and apoptosis. This effect was associated with the activation of STAT3 and mTOR/p70S6K signaling pathways. These findings suggest that LIF may serve as a potential neuroprotective agent in the treatment of glaucoma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Ophthalmology
Clarice Kai-Ying Su, Philip Yawen Guo, Poemen Pui Man Chan, Alexander Ka-Ngai Lam, Christopher Kai Shun Leung
Summary: The purpose of this study was to investigate the prevalence, patterns, and risk factors of retinal nerve fiber layer (RNFL) defects in patients with ocular hypertension (OHT). The study found that a considerable proportion of OHT patients exhibited RNFL defects, which may represent an early sign of glaucoma. Age, visual field pattern standard deviation, cup volume, and the OHTS-EPGS risk score were associated with RNFL defects.
Article
Cell Biology
Yayi Wang, Shida Chen, Jiawei Wang, Yaoming Liu, Yang Chen, Tao Wen, Xiuli Fang, Manuel Vidal-Sanz, Jost B. Jonas, Xiulan Zhang
Summary: The study identified the key role of miR-93 in retinal microglial cells' reaction, showing that its overexpression can significantly reduce microglial functions, cytokine release, and subsequent RGCs death, while inhibiting the STAT3 pathway for neuroprotection.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Mi-Lyang Kim, Kyung Rim Sung, Junki Kwon, Go Woon Choi, Jin A. Shin
Summary: In this study, it was found that statins can promote the survival of RGCs and reduce apoptosis in a rat model of glaucoma. Additionally, statins were shown to suppress glial activation in the retina, suggesting a potential for statins in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yu Sawada, Makoto Araie, Hitomi Shibata, Takeshi Iwase
Summary: This study used SD-OCT to investigate the nasal displacement of central retinal vessel (CRV) on the optic nerve head (ONH) in glaucoma and its association with the vessel's path through the lamina cribrosa (LC). The results showed that greater nasal displacement of the CRV was significantly associated with worse glaucomatous visual field defects and a more nasally angled path through the LC.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Todd McLaughlin, Jinli Wang, Liyun Jia, Fuguo Wu, Yaqin Wang, Joshua J. Wang, Xiuqian Mu, Sarah X. Zhang
Summary: The chaperone p58(IPK) plays a protective role in the retina by reducing retinal ganglion cell (RGC) injury, which is mediated through its expression in retinal neurons. This finding provides a new direction and strategy for the treatment of neurodegenerative retinal diseases.
Article
Computer Science, Information Systems
Khursheed Aurangzeb, Rasha Sarhan Alharthi, Syed Irtaza Haider, Musaed Alhussein
Summary: Early detection of eye diseases is crucial, and the use of artificial intelligence based on deep learning has shown promise in improving accuracy and efficiency in diagnosis. This study focuses on developing a lightweight DL model for retinal vessel segmentation, which demonstrates superior performance compared to other methods in terms of reduced computational complexity and improved segmentation results.
Review
Medicine, General & Internal
Aleksandra Zgryzniak, Joanna Przezdziecka-Dolyk, Marek Szalinski, Anna Turno-Krecicka
Summary: Selective laser trabeculoplasty (SLT) is an effective treatment for reducing intraocular pressure in open-angle glaucoma and ocular hypertension. It can be used as a primary or adjunct therapy, helping to reduce medication use and achieve target IOP with low complication rates and the potential for repeat procedures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Daniel Jamrozik, Radoslaw Dutczak, Joanna Machowicz, Alicja Wojtyniak, Adrian Smedowski, Marita Pietrucha-Dutczak
Summary: Metallothioneins are metal-rich proteins that play important roles in metal homeostasis and detoxification, as well as protecting cells against oxidative stress and promoting cell survival and differentiation. In the eye, these proteins are vital for protecting neuronal retinal cells and disruption in their expression may contribute to age-related eye diseases. This review emphasizes the potential of metallothioneins as a key component of the retinal neurons' endogenous protection system and discusses their expression changes in common eye diseases, as well as their potential as biomarkers for cancer diagnosis.
Article
Ophthalmology
Yasemin Saruhan, Olivia Bollinger, Konstantin Gugleta
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2020)
Article
Ophthalmology
Olga Zabek, Georgios D. Panos, Despoina Sagri, Konstantin Gugleta, Hendrik P. N. Scholl, Zisis Gatzioufas
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2020)
Article
Ophthalmology
Olivia Bollinger, Yasemin Saruhan, Konstantin Gugleta
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2020)
Editorial Material
Ophthalmology
Maria della Volpe Waizel, Zisis Gatzioufas, Stella Veliki, Despoina Sagri, Konstantin Gugleta, Hendrik P. N. Scholl, Nikolaos Kozeis
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2020)
Article
Ophthalmology
Selim Orgul, Konstantin Gugleta, Matthias C. Grieshaber, Andreas Schoetzau
INTERNATIONAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Lukas Streese, Lukas Y. Brawand, Konstantin Gugleta, Peter M. Maloca, Walthard Vilser, Henner Hanssen
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2020)
Article
Medicine, General & Internal
Giovanni Baranello, Basil T. Darras, John W. Day, Nicolas Deconinck, Andrea Klein, Riccardo Masson, Eugenio Mercuri, Kristy Rose, Muna El-Khairi, Marianne Gerber, Ksenija Gorni, Omar Khwaja, Heidemarie Kletzl, Renata S. Scalco, Timothy Seabrook, Paulo Fontoura, Laurent Servais
Summary: In a study involving 21 infants with type 1 spinal muscular atrophy, treatment with oral risdiplam resulted in increased levels of functional SMN protein in the blood. Infants in the high-dose group were more likely to sit without support for at least 5 seconds, and the higher dose of risdiplam was selected for the second part of the study.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Basil T. Darras, Riccardo Masson, Maria Mazurkiewicz-Beldzinska, Kristy Rose, Hui Xiong, Edmar Zanoteli, Giovanni Baranello, Claudio Bruno, Dmitry Vlodavets, Yi Wang, Muna El-Khairi, Marianne Gerber, Ksenija Gorni, Omar Khwaja, Heidemarie Kletzl, Renata S. Scalco, Paulo Fontoura, Laurent Servais
Summary: In this study involving infants with type 1 SMA, treatment with risdiplam resulted in higher percentages of infants who achieved motor milestones and showed improvements in motor function compared to historical controls. Longer and larger trials are needed to confirm the long-term safety and efficacy of risdiplam in infants with type 1 SMA.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Ophthalmology
Kengadhevi Yogeswaran, Joao M. Furtado, Bahram Bodaghi, Janet M. Matthews, Justine R. Smith
Summary: Ocular toxoplasmosis is a common global infection. This study provides an overview of the current management approach for ocular toxoplasmosis based on a survey completed by uveitis-specialised ophthalmologists from 48 countries. The findings include clinical features, diagnostic methods, treatment options, and follow-up practices. The majority of respondents used clinical examination and serology for diagnosis, and oral trimethoprim-sulfamethoxazole was the most commonly used first-line therapy. Follow-up and prophylaxis against recurrence were also discussed.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Correction
Ophthalmology
Giulia Saletta, Antonios Alexoudis, Zisis Gatzioufas, Matthias Grieshaber, Anthia Papazoglou, Markus Tschopp, Marc Toteberg, Konstantin Gugleta
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Ophthalmology
Giulia Saletta, Antonios Alexoudis, Zisis Gkatzioufas, Matthias Grieshaber, Anthia Papazoglou, Markus Tschopp, Marc Toeteberg, Konstantin Gugleta
Summary: This study analyzed the data from two Swiss multicenter studies on XEN45 and PreserFlo Microshunt implant devices. The results showed that both methods achieved satisfactory intraocular pressure control within a 12-month postoperative period, but the XEN45 group had a higher number of subsequent interventions compared to the PreserFlo Microshunt group.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Ophthalmology
Alexandra Bograd, Dominic Fuchs, Josephin Baechtiger, Isabel B. Pfister, Jan Spindler, Florence Hoogewoud, Konstantin Gugleta, Christian Boeni, Yan Guex-Crosier, Justus G. Garweg, Christoph Tappeiner
Summary: This retrospective study found that the addition of tumor necrosis factor-alpha inhibitors (TNFi) effectively improved central retinal thickness and best corrected visual acuity in patients with uveitic macular edema unresponsive to conventional synthetic disease-modifying anti-rheumatic drugs. The need for systemic corticosteroids also decreased. Rescue treatments were still required for some patients.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, General & Internal
Lukas Streese, Josephine Gander, Justin Carrard, Christoph Hauser, Timo Hinrichs, Arno Schmidt-Trucksass, Konstantin Gugleta, Henner Hanssen
Summary: This study aims to investigate vascular damage in patients with hypertension compared to healthy controls, using newly developed retinal microvascular biomarkers. The reversibility of retinal end-organ damage will be evaluated through an 8-week supervised high-intensity interval training (HIIT) program, comparing it with standard physical activity recommendations. The study will assess the effects on blood pressure, cardiorespiratory fitness, and macrovascular and microvascular health.
Article
Clinical Neurology
Tim Woelfle, Silvan Pless, Oscar Reyes, Andrea Wiencierz, Anthony Feinstein, Pasquale Calabrese, Konstantin Gugleta, Ludwig Kappos, Johannes Lorscheider, Yvonne Naegelin
Summary: This study aimed to assess the reliability and meaningfulness of tests conducted through a smartphone application for people with multiple sclerosis (PwMS). The results showed that the tested features were reliable and meaningful to PwMS. However, further research is needed to validate these measures as digital biomarkers in PwMS.
JOURNAL OF NEUROLOGY
(2023)
Article
Ophthalmology
Olivia Bollinger, Konstantin Gugleta, L. Schmetterer, Pascal W. Hasler, Jacqueline Chua Yu Min, Damon Wong Wing Kee
Summary: This study analysed data from primary open-angle glaucoma patients to investigate the correlations between optical coherence tomography (OCT) structural parameters, OCT angiography (OCTA) parameters, and visual field (VF) parameters. The results showed significant correlations between the three parameters at baseline, but no correlations were found during the one-year follow-up. The study emphasizes the importance of regularly conducting both structural and functional examinations in glaucoma patients.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)