Article
Ophthalmology
Frank G. Holz, Piotr Oleksy, Federico Ricci, Peter K. Kaiser, Joachim Kiefer, Steffen Schmitz-Valckenberg
Summary: This study demonstrated the clinical equivalence of the proposed biosimilar FYB201 and reference ranibizumab in treating patients with nAMD. Both treatments showed improvement in visual acuity and had comparable rates of adverse events.
Article
Ophthalmology
Rachael C. Heath Jeffery, Syed Aqif Mukhtar, Derrick Lopez, David B. Preen, Ian L. McAllister, David A. Mackey, Nigel Morlet, William H. Morgan, Fred K. Chen
Summary: The study reported the age-standardized annual incidence of blindness due to AMD and the treatment patterns in Australia. The incidence of blindness rose during the PDT era but declined in the IVT era. The age at AMD blindness registration increased over time, with different trends in PDT and IVT usage.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yeon-Kyoung Cho, Dae-Hun Park, In-Chul Jeon
Summary: Age-related macular degeneration (AMD) is central vision loss associated with aging and has various risk factors. Treatment options include device-based therapy, anti-inflammatory drugs, anti-VEGF drugs, and natural products. Natural products used as AMD drugs, mainly administered orally, can be combined with other treatments for potential therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Yunxia Gao, Fang Lu, Xiaoxin Li, Hong Dai, Kun Liu, Xiaoling Liu, Zuhua Sun, Jin Xiang, Lieming Ding, Chris Liang, Yang Wang, Zhilin Shen, Ming Zhang
Summary: Objective: To evaluate the efficacy and safety of oral vorolanib for neovascular (wet) age-related macular degeneration (nAMD) treatment. Methods: Participants received ascending doses of oral vorolanib in dose escalation and recommended doses in the dose expansion. Results: Oral administration of vorolanib improved visual outcomes in participants with nAMD with manageable systemic safety profiles. Conclusions: Vorolanib shows potential as a treatment for nAMD with acceptable safety and efficacy.
Article
Multidisciplinary Sciences
Hoseok Yeom, Hye Ji Kwon, Yoon Jeon Kim, Junyeop Lee, Young Hee Yoon, Joo Yong Lee
Summary: This retrospective study assessed the safety and effectiveness of switching to intravitreal brolucizumab for refractory nAMD. The results showed that the majority of patients experienced improved anatomical outcomes or extended injection intervals after switching. Certain structural biomarkers were identified as predictors of treatment response, aiding in the selection of an appropriate therapeutic strategy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Semra Ozdemir, Eric Finkelstein, Jia Jia Lee, Issac Horng Khit Too, Kelvin Yi Chong Teo, Anna Chen Sim Tan, Tien Yin Wong, Gemmy Chui Ming Cheung
Summary: This study investigated the relative importance of convenience and treatment outcomes, as well as how patient characteristics affect treatment preferences.
Review
Medicine, Research & Experimental
Levon M. Khachigian, Gerald Liew, Kelvin Y. C. Teo, Tien Y. Wong, Paul Mitchell
Summary: Neovascular age-related macular degeneration (nAMD) is a leading cause of visual impairment and blindness, but current anti-VEGF therapies have limitations. This article discusses the need for new and improved therapies for nAMD and explores the efficacy of multi-targeted therapies that target both the VEGF pathway and other pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Junyeop Lee, You Na Kim, June-Gone Kim
Summary: Monthly alternating injections of aflibercept and bevacizumab were effective in preventing deterioration in patients with neovascular age-related macular degeneration who were not responding to bimonthly injections.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Arshad M. Khanani, Aamir A. Aziz, Hannah Khan, Ashwin Gupta, Ohidul Mojumder, Aigerim Saulebayeva, Ashkan M. Abbey, David R. P. Almeida, Robert L. Avery, Himanshu K. Banda, Mark R. Barakat, Ramanath Bhandari, Emmanuel Y. Chang, Sara J. Haug, Nikolas J. S. London, Luke Mein, Veeral S. Sheth, Jeremy D. Wolfe, Michael A. Singer, Carl J. Danzig
Summary: This study retrospectively analyzed real-world patients receiving faricimab for the treatment of neovascular age-related macular degeneration (nAMD). The results showed that faricimab can improve or maintain visual acuity and rapidly improve anatomical parameters. It was well-tolerated with a low incidence of treatable intraocular inflammation.
Article
Endocrinology & Metabolism
Karen Mulligan, Jaehong Kim, Bryan Tysinger, Jill Blim, Geoffrey Emerson, Philip J. Ferrone, Judy E. Kim, Seth Seabury, Paul Hahn
Summary: This study simulates economic outcomes for individuals with diabetic macular edema (DME) and finds that treatment significantly improves patients' vision, life expectancy, and quality of life, as well as positively affects employment and disability outcomes.
Article
Ophthalmology
Imoro Zeba Braimah, Winfried M. Amoaku
Summary: The study found that intravitreal ziv-aflibercept (IVZ) is associated with significant improvement in best-corrected visual acuity (BCVA) and reduction in central macular thickness (CMT) in patients with diabetic macular edema (DME).
Article
Ophthalmology
Pravin U. Dugel, Rishi P. Singh, Adrian Koh, Yuichiro Ogura, Georges Weissgerber, Kinfemichael Gedif, Glenn J. Jaffe, Ramin Tadayoni, Ursula Schmidt-Erfurth, Frank G. Holz
Summary: The study reported the 96-week outcomes of nAMD patients treated with brolucizumab and aflibercept, showing that brolucizumab was more effective in improving vision and reducing retinal fluid compared to aflibercept. The results from both studies confirmed that the efficacy observed at 48 weeks was maintained at 96 weeks.
Article
Ophthalmology
Xin-Yu Zhao, Li-Hui Meng, Sheng-zhi Liu, You-Xin Chen
Summary: Through network meta-analysis, the study found that the T&E strategy showed good efficacy in the treatment of neovascular age-related macular degeneration; there was no significant difference in efficacy among ranibizumab, bevacizumab, and aflibercept under the same strategy; the risk of ADEs with different anti-VEGF treatment regimens was acceptable.
ACTA OPHTHALMOLOGICA
(2021)
Review
Medicine, General & Internal
Andrea C. Tricco, Sonia M. Thomas, Erin Lillie, Areti Angeliki Veroniki, Jemila S. Hamid, Ba' Pham, Taehoon Lee, Arnav Agarwal, Jane P. Sharpe, Alistair Scott, Rachel Warren, Ronak Brahmbhatt, Erin Macdonald, Ghayath Janoudi, Rajeev H. Muni, Carolina L. M. Francisconi, Trevor Richter, Sharon E. Straus
Summary: The study revealed that ranibizumab, bevacizumab, aflibercept, and brolucizumab were statistically superior to conbercept in terms of the proportion of patients with nAMD who experienced moderate vision gain. However, these findings were based on indirect evidence from one small trial and did not account for drug-specific differences.
SYSTEMATIC REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Jose Navarro-Partida, Juan Carlos Altamirano-Vallejo, Luis Abraham Aceves Franco, Jesus Gonzalez-Cortes, Sergio Hernandez-Da Mota, Jose Gerardo Garcia-Aguirre, Carlos David Azuara-Galindo, Carlos Rodrigo Castro-Castaneda, Juan Armendariz-Borunda, Arturo Santos
Summary: A study evaluated the safety and efficacy of using a triamcinolone-loaded liposome formulation as an adjuvant to intravitreal ranibizumab therapy in treatment-naive patients with neovascular age-related macular degeneration. The results showed a significant reduction in the average number of ranibizumab injections when using the liposome formulation, with optimal visual and anatomic outcomes.
Article
Endocrinology & Metabolism
Francesco Zaccardi, Pui San Tan, Carol Coupland, Baiju R. Shah, Ash Kieran Clift, Defne Saatci, Martina Patone, Simon J. Griffin, Hajira Dambha-Miller, Kamlesh Khunti, Julia Hippisley-Cox
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Abdullah Almaqhawi, Patrick Highton, Mukund Narasimhan, Melanie J. Davies, Kamlesh Khunti, Samuel Seidu
Summary: This study evaluated the educational quality and reliability of YouTube videos on diabetes foot examinations. The majority of the videos were found to be low in quality and reliability. It is recommended to access high-quality foot examination videos from reputable sources.
Article
Health Care Sciences & Services
Karen O. B. Appiah, Kamlesh Khunti, Benjamin M. Kelly, Aidan Q. Innes, Zhining Liao, Michael Dymond, Robert G. Middleton, Thomas W. Wainwright, Thomas Yates, Francesco Zaccardi
Summary: This study aimed to develop risk scores of preoperative patient factors and patient-reported outcome measures (PROMs) as predictors of patient-rated satisfaction and improvement following hip and knee replacements. Analysis of prospectively collected patient data showed that preoperative PROMs were closely related to surgical outcomes. Prediction models were developed to predict dissatisfaction and lack of improvement following surgery based on easily accessible preoperative patient factors and PROMs.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Mary M. Barker, Melanie J. Davies, Francesco Zaccardi, Emer M. Brady, Andrew P. Hall, Joseph J. Henson, Kamlesh Khunti, Amelia Lake, Emma L. Redman, Alex V. Rowlands, Jane Speight, Tom Yates, Jack A. Sargeant, Michelle Hadjiconstantinou
Summary: This study investigated the association between age at diagnosis of type 2 diabetes and depressive symptoms, diabetes-specific distress, and self-compassion. The results showed that younger age at diagnosis was significantly associated with higher levels of depressive symptoms and diabetes-specific distress, and lower levels of self-compassion.
Article
Endocrinology & Metabolism
Naomi Holman, Emma Barron, Bob Young, Edward W. Gregg, Kamlesh Khunti, Jonathan Valabhji, Naveed Sattar
Summary: This study aimed to investigate whether COVID-19 increases the incidence of diabetes. The results showed that COVID-19 did not have a significant impact on the incidence of diabetes compared to people hospitalized with pneumonia.
Article
Endocrinology & Metabolism
Angels Mollo, Bogdan Vlacho, Monica Gratacos, Manel Mata-Cases, Esther Rubinat, Anna Berenguera, Jordi Real, Ramon Puig-Treserra, Xavier Cos, Josep Franch-Nadal, Kamlesh Khunti, Didac Mauricio, INTEGRA Res grp
Summary: A specially designed multicomponent healthcare intervention can improve glycaemic control in subjects with poorly controlled type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jodie Chan, David Blane, Pratik Choudhary, Tahseen A. Chowdhury, Aaliya Goyal, Wasim Hanif, Joyce Jacca, Rohini Mathur, Shivani Misra, Nana Ocran, Martin K. Rutter, Ruth Studley, Shaun Treweek, Jonathan Valabhji, Kamlesh Khunti
Summary: This article aims to develop a position statement that identifies research priorities to address health inequalities in diabetes and provides recommendations to researchers and research funders on how best to conduct research in these areas. By conducting a two-day research workshop, experts from various fields were able to identify key areas that need increased focus, such as improving patient and public involvement in research, improving research design to represent the people who could benefit most, and using theories from implementation science to facilitate the uptake of research findings into routine practice. The article emphasizes the urgency of addressing health inequalities in diabetes and calls on the diabetes research community to act upon the recommendations outlined in the position statement.
Article
Endocrinology & Metabolism
Emma Barron, Dominque Bradley, Soraya Safazadeh, Ben McGough, Chirag Bakhai, Bob Young, Kamlesh Khunti, Elizabeth Murray, Nick Wareham, Susan Jebb, Jonathan Valabhji
Summary: The study assessed weight change in the NHS Diabetes Prevention Programme delivered via remote or digital interventions during the COVID-19 pandemic compared to face-to-face interventions before the pandemic. The findings showed that remote and digital interventions resulted in greater weight loss compared to face-to-face interventions, without exacerbating health inequalities.
Article
Cardiac & Cardiovascular Systems
Samuel Seidu, Clare Gillies, Francesco Zaccardi, Katharine Reeves, Suzy Gallier, Kamlesh Khunti
Summary: Admissions for atrial fibrillation (AF) and severe bleeding associated with AF have increased in England between 2001 and 2018. The slight drop in admissions for severe bleeding between 2013 and 2014 may not be directly related to the introduction of DOACs in 2014. Further research is needed to determine the contributors to these trends.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
Yogini V. V. Chudasama, Kamlesh Khunti
Review
Medicine, General & Internal
Lauren L. O'Mahoney, Ash Routen, Clare Gillies, Winifred Ekezie, Anneka Welford, Alexa Zhang, Urvi Karamchandani, Nikita Simms-Williams, Shabana Cassambai, Ashkon Ardavani, Thomas J. Wilkinson, Grace Hawthorne, Ffion Curtis, Andrew P. Kingsnorth, Abdullah Almaqhawi, Thomas Ward, Daniel Ayoubkhani, Amitava Banerjee, Melanie Calvert, Roz Shafran, Terence Stephenson, Jonathan Sterne, Helen Ward, Rachael A. Evans, Francesco Zaccardi, Shaney Wright, Kamlesh Khunti
Summary: This study systematically synthesized global evidence on the prevalence of persistent symptoms in a general post COVID-19 population. The findings show that regardless of hospitalization status, at least 45% of COVID-19 survivors experience unresolved symptoms for about 4 months. The current understanding of Long Covid is limited by heterogeneous study design, follow-up durations, and measurement methods, hindering effective treatment and management strategies.
Article
Endocrinology & Metabolism
Emma Barron, Kamlesh Khunti, Alison K. Wright, Darren M. Ashcroft, Matthew J. Carr, Martin K. Rutter, Jonathan Valabhji
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Kamlesh Khunti, Mussa Almalki, Juliana C. N. Chan, Aslam Amod
Summary: Real-world evidence (RWE) is vital in the management of type 2 diabetes (T2D), providing valuable data about intervention effectiveness and safety outside of randomised controlled trials (RCTs). This review highlights the value of RWE in day-to-day clinical practice, particularly with sulfonylureas (SUs), and presents examples of international real-world studies in people with T2D. RWE informs healthcare professionals (HCPs), regulatory authorities, and improves treatment adherence and patient quality of life.
Review
Immunology
Winifred Ekezie, Aaisha Connor, Emma Gibson, Kamlesh Khunti, Atiya Kamal
Summary: COVID-19 has disproportionately affected ethnic minority populations with higher morbidity and mortality rates, but their vaccine uptake remains lower than non-minoritised groups. This systematic review examines behaviour change techniques in interventions aimed at increasing vaccination uptake among ethnic minority communities. The review includes 23 studies that categorise interventions using the Behaviour Change Wheel and Behaviour Change Taxonomy v1. The study finds that effective interventions are multi-component and tailored to specific populations, with education, persuasion, and enablement being the main intervention functions used. Raising awareness and involving community organizations show positive effects in increasing vaccine acceptance.
Review
Geriatrics & Gerontology
Elizabeth Hickman, Mansha Seawoodharry, Clare Gillies, Kamlesh Khunti, Samuel Seidu
Summary: This systematic review investigates deprescribing practices and outcomes in older patients with end-of-life designation or residing in long-term care facilities with cardiometabolic conditions. Results suggest that controlled and regularly monitored deprescribing of preventive medications is feasible and beneficial in this patient population. However, further research is needed due to limited evidence and study heterogeneity to fully assess the benefits of deprescribing in this group.
