Article
Ophthalmology
Jeong-Ah Kim, Seung Hyen Lee, Dong Hwan Son, Tae-Woo Kim, Eun Ji Lee, Michael J. A. Girard, Jean Martial Mari
Summary: This study aimed to investigate whether the curve of the lamina cribrosa changes in eyes with normal tension glaucoma after receiving topical ocular hypotensive eye drops. OCT scans were used to measure the lamina cribrosa curvature in each eye before and after intraocular pressure (IOP)-lowering treatment. The results showed that there were significant changes in the lamina cribrosa curvature in some eyes after IOP reduction.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Joseph Park, Andrew Shin, Joseph L. Demer
Summary: This study used a finite element model to simulate the tractional tethering of the optic nerve during adduction of the eye and analyzed the effects of different tissue properties on stress. The simulations showed that adduction tethering can lead to stress concentration in certain regions of the eye, potentially causing damage to the optic nerve.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Mi Sun Sung, Hyung Nam Jin, Sang Woo Park
Summary: The study found that the presence of optic nerve head (ONH) prelaminar schisis in eyes with advanced glaucoma is associated with specific characteristics of the lamina cribrosa and macular thickness. In patients with these features, macular measurements are better predictors of functional status than peripapillary or ONH measurements.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ryan G. Strickland, Mary Anne Garner, Alecia K. Gross, Christopher A. Girkin
Summary: Glaucomatous optic neuropathy is the main cause of irreversible blindness worldwide. Lowering intraocular pressure is the only proven treatment, but it does not prevent further nerve degeneration. Cells in the optic nerve head, including lamina cribrosa cells, glial cells, and scleral fibroblasts, respond to glaucomatous conditions through extracellular matrix remodeling. Therefore, researching alternative therapies to alter this remodeling response is crucial for enhancing the survival of retinal ganglion cell axons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Ziyi Zhu, Susannah Waxman, Bo Wang, Jacob Wallace, Samantha E. Schmitt, Elizabeth Tyler-Kabara, Hiroshi Ishikawa, Joel S. Schuman, Matthew A. Smith, Gadi Wollstein, Ian A. Sigal
Summary: The study found that changes in IOP and ICP significantly deformed the scleral canal and lamina of the monkey ONH. There were individualized responses to pressure manipulation between eyes, and significant interactions between the effects of IOP and ICP on LC depth, BMO area, aspect ratio and planarity. Overall, elevating both pressures did not cancel out the effects in most eyes.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Ali Salehi, Madhusudhanan Balasubramanian
Summary: The study aims to propose a new structural biomarker for detecting glaucoma progression based on the structural transformation of the optic nerve head (ONH) region over time. Dense ONH deformation was estimated using deep learning methods and legacy computational methods. The diagnostic accuracy of the biomarker was evaluated using the area under the ROC curve.
Article
Ophthalmology
Arthur J. Sit, Teresa C. Chen, Hana L. Takusagawa, Jullia A. Rosdahl, Ambika Hoguet, Vikas Chopra, Grace M. Richter, Yvonne Ou, Stephen J. Kim, Darrell WuDunn, Andre Ambrus
Summary: This review examines the utility of corneal hysteresis (CH) in diagnosing glaucoma and assessing the risk of disease progression. After analyzing 19 selected articles, it was found that CH is lower in glaucoma patients compared to normal subjects. The measurement of CH complements current assessments in determining disease risk in glaucoma patients.
Article
Ophthalmology
Satish K. Panda, Haris Cheong, Tin A. Tun, Sripad K. Devella, Vijayalakshmi Senthil, Ramaswami Krishnadas, Martin L. Buist, Shamira Perera, Ching-Yu Cheng, Tin Aung, Alexandre H. Thiery, Michael J. A. Girard
Summary: This study develops a novel deep-learning approach for describing the structural phenotype of the glaucomatous optic nerve head (ONH) and serving as a robust glaucoma diagnosis tool. By analyzing the latent parameters, it reveals the changes in ONH morphology during the transition from a non-glaucoma to a glaucoma condition.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Makoto Sasaki, Tomomi Higashide, Satoshi Takeshima, Yuki Takamatsu, Yoshimi Manbo, Sachiko Udagawa, Kazuhisa Sugiyama
Summary: A study on patients with open-angle glaucoma who underwent trabeculectomy showed that MT increased significantly in the PPA region with choroid present, and a decrease in IOP was associated with an increase in BOS across all regions, indicating that reducing IOP may stabilize blood flow uniformly despite structural differences between regions.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Alireza Kamalipour, Sasan Moghimi, Medi Eslani, Takashi Nishida, Vahid Mohammadzadeh, Eleonora Micheletti, Christopher A. Girkin, Massimo A. Fazio, Jeffrey M. Liebmann, Linda M. Zangwill, Robert N. Weinreb
Summary: This prospective cohort study evaluated the role of corneal hysteresis (CH) in central visual field (VF) progression in glaucoma suspect and glaucoma patients. The results showed that lower CH was significantly associated with 10-2 and 24-2 VF progression. Lower CH was also associated with a faster rate of decline in 10-2 mean deviation (MD) and an increased likelihood of 10-2 VF progression.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sachin Kedar, Junfei Tong, John Bader, Shane Havens, Shan Fan, William Thorell, Carl Nelson, Linxia Gu, Robin High, Vikas Gulati, Deepta Ghate
Summary: The study found that acute changes in CSFP/ICP did not have a significant effect on ONH morphological parameters in both humans and pigs, suggesting compensatory and opposing changes in IOP and CSFP/ICP may contribute to the lack of measurable morphological changes in the ONH.
CURRENT EYE RESEARCH
(2022)
Article
Immunology
Wenwen Lai, Jie Huang, Wangyi Fang, Saiyue Deng, Yi Xie, Wei Wang, Tong Qiao, Gezhi Xu, Xiaowei Wang, Fengfei Ding
Summary: This study investigates the role of optic nerve head (ONH) in defense against vitreous inflammation. The researchers found that while the retina showed signs of inflammation, the posterior optic nerve and the optic nerve head showed no signs of inflammation or infiltration of inflammatory cells. The study also found that the astrocytes in the ONH changed their spatial orientation in response to inflammation. The findings suggest that glial responses in the ONH may serve as a barrier to inflammation for the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jayoung Ahn, Daniel Duck-Jin Hwang
Summary: This study evaluated longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in eyes affected with branch and central retinal vein occlusion (BRVO and CRVO, respectively) and fellow eyes. It found that the global pRNFL thickness of fellow eyes in the BRVO and CRVO groups decreased significantly at 24 months compared to baseline, while the fellow eyes of patients with CRVO had significantly lower pRNFL thickness at 12 and 24 months compared to those of the BRVO and normal control groups. These results suggest that fellow eyes of patients with BRVO and CRVO are susceptible to pRNFL damage.
SCIENTIFIC REPORTS
(2021)
Review
Ophthalmology
H. Claudel, P. Bastelica, P. Hamard, A. Labbe, C. Baudouin
Summary: Glaucoma is a chronic eye disease characterized by progressive changes in the optic nerve. Intraocular pressure is the main factor causing these changes, and the biomechanical properties of the lamina cribrosa are involved in the pathogenesis of glaucoma. The lamina cribrosa is a dynamic structure that plays a key role in the development of glaucoma. Some deformations are reversible, which is important for the treatment of glaucoma.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2023)
Article
Ophthalmology
Tanya S. Glaser, Michelle S. Go, Michael P. Kelly, Mays S. El-Dairi, Sharon F. Freedman
Summary: This study examined the structural changes in the optic nerve head (ONH) and macula in infants with childhood glaucoma and observed ONH cupping reversal following glaucoma surgery. The results showed that IOP-reducing surgery led to a reduction in axial length and cup depth, but there was no significant change in the pRNFL or macular volume measures. The findings suggest that ONH cupping reversal may indicate stabilization, but previous ONH damage persists.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)