Review
Medicine, General & Internal
Lamprini Banou, Anna Dastiridou, Athanasios Giannoukas, Georgios Kouvelos, Christos Baros, Sofia Androudi
Summary: Glaucoma, a progressive optic neuropathy, is a major cause of irreversible blindness globally. Elevated intraocular pressure (IOP) and impaired intraocular blood flow are considered to be involved in the pathogenesis of glaucoma. Color Doppler Imaging (CDI), a technique used in ophthalmology, has been used to assess ocular blood flow (OBF) and plays a role in both diagnosis and monitoring of glaucoma progression. This article reviews the role of CDI, presents imaging protocol and advantages, and analyzes the vascular theory and its role in glaucoma.
Article
Computer Science, Interdisciplinary Applications
Jianbo Tang, Kivilcim Kilic, Thomas L. Szabo, David A. Boas
Summary: The improved color Doppler-based functional ultrasound imaging method (iCD-fUS) overcomes mutual frequency cancellation and accurately quantifies blood flow velocities in the rodent brain, with a spatial resolution of approximately 100 μm. iCD-fUS has the potential to study brain activation and provides a powerful, quantitative tool for in vivo chronic research.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Acoustics
JunShu Li, JinYun Chen, Yong Wang, Liang Hu, Rong Zhang, WenZhi Chen
Summary: This study aimed to assess the changes in blood flow in adenomyosis patients after higher-dose oxytocin (OT) and to evaluate its safety. The results showed that OT effectively reduced the blood flow volume in the lesions of adenomyosis, and continuous intravenous infusion of 0.12 U/min of OT is an appropriate and safe dose.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Physiology
J. Carter Luck, Allen R. Kunselman, Michael D. Herr, Cheryl A. Blaha, Lawrence I. Sinoway, Jian Cui
Summary: This study aimed to investigate if increasing the number of LDF probes in a localized area improves the reproducibility of skin blood flow measurements. The results show that using multiple LDF probes in a custom-made holder provides excellent reproducibility after replacing the probes within the same participant. This is important for repeated measurements that require removal and replacement of probes at the same location.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemical Research Methods
Dongkai Cheng, Jiabin Wang, Tomoyuki Yokota, Takao Someya
Summary: This study focuses on overcoming challenges in processing photoplethysmography (PPG) signals by using a combination of direct-contact-type, lens-less, conformable imagers and singular value decomposition (SVD) technology. The research successfully demonstrated skin microcirculation blood tracking and vessel visualization by applying the lens-less, conformable, wearable imagers.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Agriculture, Dairy & Animal Science
T. Minela, J. R. Pursley
Summary: The study aimed to establish timelines for assessing luteolysis via Doppler ultrasonography. Different doses of CLO had varying effects on the corpus luteum, with the full dose treatment resulting in less LBF and LV reduction.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Engineering, Biomedical
Yang Zhang, Joshua Olick-Gibson, Anjul Khadria, Lihong V. Wang
Summary: Photoacoustic vector tomography (PAVT) is a method that uses successive single-shot wide-field photoacoustic images to estimate blood flow speed and direction at depths greater than 5 mm from the skin's surface. It breaks the optical diffusion limit and allows for the quantification of haemodynamics in deep veins.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Rheumatology
Kang Xue, Tingting Guo, Boya Lei, Sheng Chen, Linlin Huang, Min Zhou
Summary: This study analyzed the blood flow in retrobulbar vessels in patients with systemic lupus erythematosus (SLE) using color Doppler imaging (CDI). The results showed blood flow abnormalities in the central retinal artery (CRA) and posterior ciliary arteries (PCA). Disease duration was negatively correlated with blood flow velocities in the CRA, PCA, and ophthalmic artery (OA). The SLE Disease Activity Index was significantly related to the pulsatility index (PI) of the OA. Patients treated with biological agents had lower blood flow velocities in the CRA and PCA. SLE patients with kidney or CNS involvement had increased PI in the OA. Creatinine, the disease activity index, being positive for anti-dsDNA antibodies, and receiving biological agents were associated with measurable changes in retrobulbar blood flow.
Article
Acoustics
Jonathan M. Rubin, Sibo Li, J. Brian Fowlkes, Shriram Sethuraman, Oliver D. Kripfgans, William Shi, Marjorie C. Treadwell, James R. Jago, Ronald D. Leichner, Stephen Z. Pinter
Summary: The study compared a new method for estimating blood volume flow with the standard 1-dimensional spectral Doppler method in the umbilical vein, finding significantly less variation in estimates with the new 3-dimensional ultrasound method.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gerhard Garhoefer, Ahmed M. Bata, Alina Popa-Cherecheanu, Anton Hommer, Clemens Vass, Hemma Resch, Doreen Schmidl, Rene M. Werkmeister, Leopold Schmetterer
Summary: This study found that patients with POAG have reduced total retinal oxygen extraction, which is associated with structural and functional damage of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Luying Gao, Xiaoyan Zhang, Yuxin Jiang, Hongyan Wang, Yuehong Zheng, Wanying Li, Jianchu Li, Bo Zhang
Summary: This study investigated the blood supply and feeding arteries of carotid body tumors (CBTs) using superb microvascular imaging (SMI). The results showed that SMI was superior to color Doppler flow imaging (CDFI) in detecting the vascularity of CBTs and identified more potential feeding arteries. Additionally, CBTs originating from the internal carotid artery (ICA) were found to be less vascular than those originating from the external carotid artery (ECA).
FRONTIERS IN SURGERY
(2022)
Review
Endocrinology & Metabolism
Li Jiang, Dian Zhang, Yue-Nan Chen, Xue-Juan Yu, Mei-Fang Pan, Lian Lian
Summary: The value of conventional ultrasound-based superb microvascular imaging (SMI) and color Doppler flow imaging (CDFI) in the diagnosis of malignant thyroid nodule was evaluated and compared through meta-analysis. The results showed that SMI has better diagnostic efficiency for malignant thyroid nodules compared to CDFI, providing more information on vascularity and having better clinical application value.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Acoustics
Arkadiusz Zegadlo, Joanna Wierzbowska
Summary: The study compared retrobulbar hemodynamic measured by colour Doppler imaging in patients with different severity of glaucoma and correlated it with the structural parameters of the retina and optic disc. In eyes with advanced glaucoma, significant alterations in Doppler parameters of retrobulbar arteries were observed along with thinning of the RNFL, indicating a greater severity of optic neuropathy. Positive correlations were found between RNFL and EDV of all measured arteries.
MEDICAL ULTRASONOGRAPHY
(2021)
Article
Acoustics
Hideyuki Hasegawa, Masaaki Omura, Ryo Nagaoka
Summary: This study developed a method for estimating the center frequency specifically for high-frame-rate plane wave imaging, and its effectiveness was validated in simulations and in vivo measurements on human subjects.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Review
Biochemistry & Molecular Biology
Anna-Sophie Mursch-Edlmayr, Matthias Bolz, Clemens Strohmaier
Summary: Glaucomatous optic neuropathies have long been considered diseases caused by high intraocular pressure, but recent research has shown that vascular factors also play an important role in glaucoma. Advances in the study of ocular vasculature, ciliary circulation, retinal circulation, etc., may bring new breakthroughs in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Eirini Christinaki, Hana Kulenovic, Xavier Hadoux, Nicole Baldassini, Jan Van Eijgen, Lies De Groef, Ingeborg Stalmans, Peter van Wijngaarden
Summary: Retinal imaging is a promising method for detecting features of neurodegenerative diseases, with efforts to harmonise study designs and imaging methods being crucial for translating these findings into clinical care. Eye care providers may play important roles in the future detection of a variety of neurodegenerative diseases.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2022)
Review
Medicine, General & Internal
Anne-Sophie Simons, Ingele Casteels, John Grigg, Ingeborg Stalmans, Evelien Vandewalle, Sophie Lemmens
Summary: Glaucoma remains a frequent complication after cataract surgery in children. This review evaluates different management options for glaucoma following cataract surgery (GFCS) and proposes a clinical management strategy. Medical therapy is the first-line treatment, while surgical procedures such as angle surgery and glaucoma drainage device implantation may be considered. The literature suggests that glaucoma drainage device implantation provides the best long-term intraocular pressure control for childhood GFCS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Jesus D. Melgarejo, Jan Eijgen, Gladys E. Maestre, Lama A. Al-Aswad, Lutgarde Thijs, Luis J. Mena, Joseph H. Lee, Joseph D. Terwilliger, Michele Petitto, Carlos A. Chavez, Miguel Brito, Gustavo Calmon, Egle Silva, Dong-Mei Wei, Ella Cutsforth, Karel Keer, C. Gustavo De Moraes, Thomas Vanassche, Stefan Janssens, Ingeborg Stalmans, Peter Verhamme, Jan A. Staessen, Zhen-Yu Zhang
Summary: It was found that dips rather than increases in the 24-h MAP level were associated with an increased risk for OAG.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Letter
Ophthalmology
Peter van Wijngaarden, Xavier Hadoux, Eirini Christinaki, Lies De Groef, Ingeborg Stalmans
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Review
Computer Science, Interdisciplinary Applications
Rita Marques, Danilo Andrade De Jesus, Joao Barbosa-Breda, Jan Van Eijgen, Ingeborg Stalmans, Theo van Walsum, Stefan Klein, Pedro G. Vaz, Luisa Sanchez Brea
Summary: This review summarizes the latest technology applications of automatic segmentation of the optic nerve head (ONH) in optical coherence tomography (OCT), pointing out the lack of consensus on segmented regions, extracted parameters, and validation methods, highlighting the importance of establishing standardized methods. Only with a concrete set of guidelines, these automatic segmentation algorithms can enter clinical practice.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Ophthalmology
Luca Rossetti, Francisco Goni, Giovanni Montesano, Ingeborg Stalmans, Fotis Topouzis, Dario Romano, Eleonora Galantin, Noemi Delgado-Gonzales, Sara Giammaria, Giulia Coco, Evelien Vandewalle, Sophie Lemmens, Dimitrios Giannoulis, Theofanis Pappas, Gianluca Manni
Summary: This study aimed to determine if citicoline oral solution could improve the quality of life in patients with chronic open-angle glaucoma. A randomized, double-masked, placebo-controlled, cross-over study was conducted. The primary outcome was the change in the intra-patient composite score of the Visual Function Questionnaire-25 (VFQ-25) after citicoline oral solution vs placebo at the 6-month visit compared to baseline.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Amelien Lauwers, Joao Barbosa Breda, Ingeborg Stalmans
Summary: Glaucoma is a chronic and progressive disease that can cause irreversible blindness if not treated. The natural history of untreated glaucoma is not well understood, although reducing intraocular pressure has been proven effective in slowing disease progression. Understanding the rate of progression and conversion to advanced stages of glaucoma can guide management decisions.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Jan Van Eijgen, Alexander Heintz, Claire Van der Pluijm, Margaux Delporte, Dries De Witte, Geert Molenberghs, Joao Barbosa-Breda, Ingeborg Stalmans
Summary: This study utilized dynamic OCTA examination to compare differences between healthy individuals and glaucoma patients, as well as to distinguish subcategories of glaucoma (NTG and POAG). The results confirmed a decrease in retinal vessel density in glaucoma patients and established the necessity to correct for gender, age, and MAP. However, replication in a larger population is needed to determine whether OCTA is suitable for dynamically evaluating the retinal microvasculature.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Ewa Mrukwa-Kominek, Marta Misiuk-Hojlo, Adrienne Csutak, Ingeborg Stalmans, Gerhard Garhofer
Summary: This study compared the efficacy and safety of two fixed combination, preservative-free eye drops (bimatoprost 0.01% in combination with either timolol 0.1% or 0.5%) in a gel formulation, with bimatoprost 0.03%/timolol 0.5% in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). The results suggest that the preservative-free ophthalmic formulation of T4030a (bimatoprost 0.01%/timolol 0.1%) can be regarded as a useful tool in the therapeutic management of OAG and OHT.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Medicine, General & Internal
Freya Peeters, Stef Rommes, Bart Elen, Nele Gerrits, Ingeborg Stalmans, Julie Jacob, Patrick De Boever
Summary: The MONA.health artificial intelligence screening software showed good performance in detecting referable diabetic retinopathy (DR) and diabetic macular edema (DME). The software achieved high sensitivity and specificity on both private test set and publicly available datasets. Subgroup analysis revealed slightly lower predictive values for individuals above the age of 65 and Caucasians.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Sakari Sulonen, Sanna Leinonen, Eemil Lehtonen, Pekko Hujanen, Anu Vaajanen, Ulla Syvanen, Ruben Hemelings, Ingeborg Stalmans, Anja Tuulonen, Hannele Uusitalo-Jarvinen
Summary: In this study, real-world data recorded during the first year after the implementation of a glaucoma-specific structured electronic healthcare record (EHR) prototype were analyzed. The results showed that most patients had their intraocular pressure, optic nerve head, retinal nerve fiber layer, and visual field evaluated and some progressive changes were identified.
ACTA OPHTHALMOLOGICA
(2023)
Article
Engineering, Biomedical
Pedro G. Vaz, Luisa Sanchez Brea, Vania Bastos Silva, Jan van Eijgen, Ingeborg Stalmans, Joao Cardoso, Theo van Walsum, Stefan Klein, Joao Barbosa Breda, Danilo Andrade De Jesus
Summary: This paper presents a novel image analysis strategy that uses speckle features as biomarkers in different stages of glaucoma to increase the potential of macular Optical Coherence Tomography (OCT). The study computed a large pool of features for macular OCT volumes and collected the averaged thicknesses of ten retinal layers. Results revealed four significant features: the thicknesses of the ganglion cell layer (GCL) and the inner plexiform layer (IPL), and two OCT speckle features - the skewness of the retinal nerve fiber layer (RNFL) and the scale parameter of the generalized gamma distribution fitted to the GCL data. The findings demonstrate the potential of macular OCT speckle for glaucoma staging and its complementarity to structural measurements.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2023)
Article
Ophthalmology
Ingeborg Stalmans, Kin Sheng Lim, Francesco Oddone, Marek Fichtl, Jose I. Belda, Anton Hommer, Guna Laganovska, Cedric Schweitzer, Bogomil Voykov, Tomasz Zarnowski, Gabor Hollo
Summary: The study compared the efficacy and safety of fixed-dose combinations of NET/LAT and BIM/TIM in treating OAG and OHT, finding that NET/LAT was non-inferior to BIM/TIM in reducing intraocular pressure with comparable safety profiles.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Jesus D. Melgarejo, Jan Van Eijgen, Dongmei Wei, Gladys E. Maestre, Lama A. Al Aswad, Luis J. Mena, Thomas Vanassche, Stefan Janssens, Peter Verhamme, Karel V. Keer, Ingeborg Stalmans, ZhenYu Zhang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Jesus D. Melgarejo, Jan Van Eijgen, Dongmei Wei, Gladys E. Maestre, Lama A. Al Aswad, Luis J. Mena, Thomas Vanassche, Stefan Janssens, Peter Verhamme, ZhenYu Zhang, Karel V. Keer, Ingeborg Stalmans
JOURNAL OF HYPERTENSION
(2023)