Article
Surgery
Goran Augustin, Mislav Mikus, Branko Bogdanic, Ognjen Barcot, Mislav Herman, Marina Sprem Goldstajn, Alessandro Tropea, Salvatore Giovanni Vitale
Summary: Several scoring systems exist for the management of acute appendicitis during pregnancy. This study aimed to create a highly accurate scoring system for pregnant women and compare it to commonly used scores. The accurate scoring system could improve diagnostic efficiency and guide treatment selection.
UPDATES IN SURGERY
(2022)
Review
Clinical Neurology
Mi Su, Xiaoxiao Ouyang, Yongyan Song
Summary: This meta-analysis supports the association between depression and inflammation, with NLR being a potential indicator of depression. However, no significant differences were found in PLR and MLR values between depressed subjects and controls. Further large-scale studies are needed to evaluate the role of PLR and MLR in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Health Care Sciences & Services
Sang-Hwa Lee, Min Uk Jang, Yerim Kim, So Young Park, Chulho Kim, Yeo Jin Kim, Jong-Hee Sohn
Summary: The study indicated that both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with the reperfusion status in patients with acute ischemic stroke treated with endovascular treatment. Higher NLR and PLR values were linked to unsuccessful reperfusion after EVT, suggesting their potential utility in predicting outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Martha Fors, Santiago Ballaz, Hegira Ramirez, Francisco X. Mora, Mary Pulgar-Sanchez, Kevin Chamorro, Esteban Fernandez-Moreira
Summary: Sex-dependent differences exist in the contribution of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and mean platelet volume-to-platelet ratio (MPR) to COVID-19 severity and mortality. The mortality rate of COVID-19 is higher among men, and men have higher levels of NLR, MLR, and MPR compared to women. NLR, MLR, and PLR have better sensitivity for predicting pneumonia severity in men, while their specificity is enhanced in women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Cuiping Chen, Lei Gu, Luyun Chen, Wangwang Hu, Xiaowen Feng, Fengzhen Qiu, Zijian Fan, Qitao Chen, Jiayou Qiu, Bei Shao
Summary: The study found that both NLR and PLR are independent predictors of functional outcomes after AIS, and may help to identify high-risk patients more effectively when used together.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sai Luo, Wen-Song Yang, Yi-Qing Shen, Ping Chen, Shu-Qiang Zhang, Zhen Jia, Qi Li, Jian-Ting Zhao, Peng Xie
Summary: This study aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and D-dimer-to-fibrinogen ratio (DFR) as predictors of pneumonia and poor outcomes in patients with acute intracerebral hemorrhage (ICH). The results showed that NLR and PLR were independent predictors of pneumonia, while NLR and DFR were independent predictors of poor 90-day outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Tezcan Akin, Birkan Birben, Gokhan Akkurt, Onur Karaca, Mustafa Donmez, Sadettin Er, Mesut Tez
Summary: This study suggests that laboratory parameters alone are not sufficient for the diagnosis of acute appendicitis in pregnant women, highlighting the importance of combining clinical examination and imaging methods. While no significant differences were observed in laboratory parameters and pregnancy trimesters between the pregnant and control groups in this study, pregnant women undergoing appendectomy had a significantly higher rate of negative appendectomy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Immunology
Ebru Yuce
Summary: The role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting spontaneous preterm birth was investigated. Retrospective data collected from hospital records between February 2018 and November 2022 showed that NLR and PLR values can predict preterm birth with high sensitivity and specificity. Predicting preterm birth allows for sensitive and smooth management of the pregnancy process.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
Pengyu Gong, Yukai Liu, Yachi Gong, Gang Chen, Xiaohao Zhang, Siyu Wang, Feng Zhou, Rui Duan, Wenxiu Chen, Ting Huang, Meng Wang, Qiwen Deng, Hongchao Shi, Junshan Zhou, Teng Jiang, Yingdong Zhang
Summary: NLR, PLR, and LMR were shown to be associated with post-thrombolysis early neurological outcomes, with NLR and PLR potentially predicting early neurological deterioration, and NLR related to early neurological improvement.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Yanyan Wei, Junhui Feng, Jinbao Ma, Dongning Chen, Jingxu Chen
Summary: This study examines the role of alterations in the immune-inflammation system in affective disorders, specifically major depressive disorder (MDD) and bipolar disorder (BD). The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) are investigated as inflammation markers. The findings reveal elevated NLR and MLR in first-episode and recurrent MDD patients, as well as higher NLR and MLR and lower PLR in BD patients. Moreover, BD manic episode patients have significantly higher NLR and MLR compared to BD depressive episode patients or MDD patients. Overall, this study highlights the importance of systemic inflammation in the pathophysiology of MDD and BD, particularly during manic BD episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Sadeta Begic-Kapetanovic, Nesina Avdagic, Asija Zaciragic, Sabaheta Hasic, Nermina Babic, Adnan Hadzimuratovic
Summary: The study suggests that NLR could be a valuable tool for the diagnosis and prediction of complications in children with acute appendicitis, particularly in distinguishing different pathological grades of appendicitis. Further large multicentric studies are needed to establish the predictive power of NLR as a marker for appendicitis.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Fanchao Meng, Xiuping Yan, Junhui Qi, Fan He
Summary: This study aimed to investigate the association and potential non-linear relationship between neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) with depression. Based on a cross-sectional study of US adults, it was found that only PLR was significantly associated with depression. Furthermore, the relationships between NLR, PLR, and MLR with depression were found to be non-linear.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Qiang Hu, Weipu Mao, Tiange Wu, Zhipeng Xu, Junjie Yu, Can Wang, Saisai Chen, Shuqiu Chen, Bin Xu, Yueshuang Xu, Ming Chen
Summary: In RCC patients undergoing laparoscopic partial or radical nephrectomy, NLR and PLR were identified as biomarkers of systemic inflammation associated with increased risk of sarcopenia. The best cutoff points for predicting sarcopenia risk were NLR >2.88 and PLR >135.63, with higher levels indicating a greater risk. Adjusting for various variables, patients with NLR >2.88 and PLR >135.63 had significantly higher risks of developing sarcopenia compared to those with lower NLR or PLR levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ayse Emre, Sait Terzi, Emel Celiker, Sinan Sahin, Selcuk Yazici, Aysun Erdem, Ufuk Sadik Ceylan, Murat Asik, Kemal Yesilcimen
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Article
Medicine, General & Internal
Ozer Makay, Beyza Ozcinar, Turgay Simsek, Cumhur Arici, Bulent Gungor, Serdar Ozbas, Tamer Akca, Ali Ugur Emre, Guldeniz Karadeniz Cakmak, Mufide Akcay, Bulent Unal, Mustafa Girgin, Sadullah Girgin, Semih Gorgulu, Atakan Sezer, Adem Karatas, Ibrahim Ali Ozemir, Nihat Aksakal, Serap Erel, M. Umit Ugurlu, Ali Ilker Filiz, Can Atalay, Ali Uzunkoy, Ugur Deveci, Cetin Kotan, Gokhan Icoz, Yavuz Kurt, Abut Kebudi, N. Zafer Canturk, Yesim Erbil, Rumen Pandev, Bahadir M. Gulluoglu
BALKAN MEDICAL JOURNAL
(2017)
Article
Oncology
Guldeniz Karadeniz Cakmak, Ali U. Emre, Oge Tascilar, Fatma A. Gultekin, Sukru O. Ozdamar, Mustafa Comert
JOURNAL OF SURGICAL ONCOLOGY
(2013)
Article
Urology & Nephrology
Fatma A. Gultekin, Guldeniz K. Cakmak, Kemal Karakaya, Ali U. Emre, Oge Tascilar, Muzaffer O. Oner, Mustafa Comert, Eyup Kulah
SEMINARS IN DIALYSIS
(2013)
Article
Cardiac & Cardiovascular Systems
Nizamettin Selcuk Yelgec, Mehmet Baran Karatas, Can Yucel Karabay, Yigit Canga, Baris Simsek, Ali Nazmi Calik, Ayse Emre
Article
Medicine, General & Internal
Ahmet Zengin, Mehmet Baran Karatas, Yigit Canga, Gunduz Durmus, Ozge Guzelburc, Nizamettin Selcuk Yelgec, Ayse Emre
Summary: This study elucidated the relationship between glomerular hyperfiltration and short-term prognosis in ST-segment elevation myocardial infarction patients, finding that both high and low GFRs increased the risk of major cardiovascular events and were influenced by other factors such as low ejection fraction and previous coronary artery disease.
ISTANBUL MEDICAL JOURNAL
(2021)
Article
Oncology
Guldeniz Karadeniz Cakmak, Ali U. Emre, Oge Tascilar, Burak Bahadir, Selcuk Ozkan
Article
Gastroenterology & Hepatology
Fatma A. Gultekin, Ali U. Emre, Sevim K. Celik, Figen Barut, Ufuk Tali, Demet Sumer, Ummuhani O. Turkcu
SAUDI JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Medicine, General & Internal
Fatih Kuzu, Dilek Arpaci, Guldeniz Karadeniz Cakmak, Ali Ugur Emre, Tarik Elri, Sevil Uygun Ilikhan, Burak Bahadir, Taner Bayraktaoglu
ANNALS OF MEDICINE AND SURGERY
(2016)
Article
Biochemistry & Molecular Biology
D. Kirac, A. Erdem, T. Avcilar, K. Yesilcimen, A. I. Guney, A. Emre, S. Yazici, S. Terzi, E. C. Kaspar, S. E. Cetin, T. Isbir
CELLULAR AND MOLECULAR BIOLOGY
(2016)
Article
Medicine, General & Internal
O. Tascilar, G. K. Cakmak, A. U. Emre, H. Bakkal, N. Kandemir, U. O. Turkcu, E. O. Demir
Article
Surgery
Arif Emre, Sami Akbulut, Mehmet Yilmaz, Zehra Bozdag
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2013)
Article
Medicine, General & Internal
K. Karakaya, F. Barut, V Hanci, M. Can, M. Comert, H. B. Ucan, G. K. Cakmak, O. Irkorucu, O. Tascilar, A. U. Emre
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2015)