Review
Pharmacology & Pharmacy
Natan Roberto de Barros, Canran Wang, Surjendu Maity, Arne Peirsman, Rohollah Nasiri, Anna Herland, Menekse Ermis, Satoru Kawakita, Bruna Gregatti Carvalho, Negar Hosseinzadeh Kouchehbaghi, Rondinelli Donizetti Herculano, Zuzana Tirpakova, Seyed Mohammad Hossein Dabiri, Jean Lucas Tanaka, Natashya Falcone, Auveen Choroomi, Runrun Chen, Shuyi Huang, Elisheva Zisblatt, Yixuan Huang, Ahmad Rashad, Danial Khorsandi, Ankit Gangrade, Leon Voskanian, Yangzhi Zhu, Bingbing Li, Mohsen Akbarij, Junmin Leem, Mehmet Remzi Dokmeci, Han-Jun Kim, Ali Khademhosseini
Summary: This review discusses the latest developments in organoid engineering for biomedical applications, including improvements in engineering organoids and their applications in drug development and disease modeling. It also highlights the tools and techniques used to study organoids and their microenvironments, as well as the analysis of clinical trials and patents related to organoids, showing their potential for future personalized medicine. The challenges and future perspectives of using organoids to advance biomedical research are also discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Yu Seon Kim, Farshid Guilak
Summary: Osteoarthritis is a degenerative joint disease with limited treatment options. Tissue engineering has focused on developing strategies using hyaluronic acid-based hydrogels to alleviate symptoms and regenerate damaged tissue in osteoarthritis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Thamil Selvee Ramasamy, Yong Mei Yee, Ilyas M. Khan
Summary: Osteoarthritis is a common degenerative joint disease associated with aging, where damage to articular chondrocytes plays a key role. Understanding the complexity of cellular aging is crucial for developing new therapies targeting the specific causes of age-related functional decline in OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Engineering, Biomedical
Robert S. Rosen, Martin L. Yarmush
Summary: The process of aging poses risks to health and functionality and has been the subject of investigation for potential therapeutics. However, identifying impactful treatments has been challenging due to limited experimental validation and study design. This review explores the biological mechanisms of aging, discusses promising therapeutic strategies, and proposes a unified approach for evaluating and vetting current and future treatments.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Eva Querdel, Marina Reinsch, Liesa Castro, Deniz Kose, Andrea Bahr, Svenja Reich, Birgit Geertz, Barbel Ulmer, Mirja Schulze, Marc D. Lemoine, Tobias Krause, Marta Lemme, Jascha Sani, Aya Shibamiya, Tim Stuedemann, Maria Koehne, Constantin von Bibra, Nadja Hornaschewitz, Simon Pecha, Yusuf Nejahsie, Ingra Mannhardt, Torsten Christ, Hermann Reichenspurner, Arne Hansen, Nikolai Klymiuk, M. Krane, C. Kupatt, Thomas Eschenhagen, Florian Weinberger
Summary: The transplantation of engineered heart tissue (EHT) patches resulted in partial remuscularization of the injured heart and improved left ventricular function in a dose-dependent manner in guinea pig and pig models. Human-scale patches were successfully transplanted onto pigs in a proof-of-principle study.
Review
Cell & Tissue Engineering
Yaping Wang, Tianyun Gao, Bin Wang
Summary: Senescence is a hot topic due to the accumulation of senescent cells and inflammatory factors, leading to various senescence-related diseases. Stem cell-based therapy, particularly using mesenchymal stromal cells (MSCs), is considered a promising strategy to alleviate or cure these diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Engineering, Biomedical
Dandan Zheng, Huitong Ruan, Wei Chen, Yuhui Zhang, Wenguo Cui, Hao Chen, Hongxing Shen
Summary: Extracellular vesicles (EVs) are nano-scale vesicles derived by cell secretion with unique advantages, which benefit their wide applications in regenerative medicine. However, the in vivo therapeutic effect of EVs still greatly restricted by several obstacles. This review summarizes different strategies to enhance EV functions and introduces the latest developments of functionalized EV-loaded biomaterials in different diseases. Challenges and future directions of EVs are also discussed.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Yanxi Liu, Karan M. Shah, Jian Luo
Summary: Articular cartilage is avascular and has limited ability to repair itself, leading to degenerative joint diseases. Current clinical treatments often result in mechanically inferior cartilage. Understanding factors affecting cartilage homeostasis and exploring emerging regenerative approaches are crucial for future treatment options.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Qiuying Mai, Yanhua Han, Guopan Cheng, Rui Ma, Zhao Yan, Xiaojia Chen, Guangtao Yu, Tongkai Chen, Shu Zhang
Summary: Around 50% of men and 15-30% of women suffer from hair-related problems, causing significant psychological burden. Traditional treatments, such as drug therapy and transplantation, face challenges like adverse effects and poor drug penetration. Therefore, efforts have been made to enhance drug permeation for hair regrowth. This review focuses on transdermal strategies involving external stimulation, regeneration, and microneedles, as well as natural products as alternative agents. It also discusses skin visualization strategies and provides information on relevant patents and clinical trials.
Review
Nanoscience & Nanotechnology
Parth Chansoria, Karl Schuchard, Rohan A. Shirwaiker
Summary: The recapitulation of multiscale structure-function properties in cells, cell-secreted extracellular matrix, and natural tissues is crucial for engineering biomimetic tissue substitutes. Developing hybrid biofabrication strategies that combine multiple processes to complement each other's strengths and limitations is a key aspect for achieving multiscale biomimicry. Opportunities related to various hybridization schemes and future prospects for scale-up biofabrication have also been discussed in this work.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jeremy Boulestreau, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Analytical
Huu Tuan Nguyen, Arne Peirsman, Zuzana Tirpakova, Kalpana Mandal, Florian Vanlauwe, Surjendu Maity, Satoru Kawakita, Danial Khorsandi, Rondinelli Herculano, Christian Umemura, Can Yilgor, Remy Bell, Adrian Hanson, Shaopei Li, Himansu Sekhar Nanda, Yangzhi Zhu, Alireza Hassani Najafabadi, Vadim Jucaud, Natan Barros, Mehmet Remzi Dokmeci, Ali Khademhosseini
Summary: Engineered human tissues created by three-dimensional cell culture in a hydrogel have become a valuable tool for cancer drug discovery and regenerative medicine. The main challenge lies in delivering nutrients and oxygen to cells through vasculatures. Multiple studies have explored strategies to create functional vascular systems in engineered tissues and organ-on-a-chips. However, there are still challenges in creating vascularized tissue constructs for biological applications. This review summarizes the latest efforts in creating vasculatures and vascularized tissues for cancer research and regenerative medicine.
Review
Chemistry, Multidisciplinary
Constance Lesage, Marianne Lafont, Pierre Guihard, Pierre Weiss, Jerome Guicheux, Vianney Delplace
Summary: The osteochondral (OC) unit is essential for joint lubrication and bone constraint transmission. Currently, there is no curative treatment for OC defects, making OC regeneration a medical challenge. Over the past two decades, tissue engineering strategies have been proposed, but successful clinical translation has been limited. This systematic review provides insights into material-assisted strategies for OC regeneration, including therapeutic potential and evaluation methods.
Review
Biochemistry & Molecular Biology
Aldo Nicosia, Monica Salamone, Salvatore Costa, Maria Antonietta Ragusa, Giulio Ghersi
Summary: Biomaterials are crucial in supporting and guiding vascularization for therapeutic applications. Hydrogels, especially synthetic hydrogels, are widely utilized due to their bio-inertness and precise control over cell-material interactions. This comprehensive review showcases the latest advancements in hydrogel materials and innovative design modifications aimed at effectively guiding and supporting vascularization processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Umber Cheema
Summary: Tissue engineering is a multidisciplinary approach to building 3D human tissues in the laboratory. Despite three decades of advancements in medical sciences, there is limited use of tissue-engineered organs in humans. This position paper outlines the challenges and advancements in engineering specific tissues and organs, as well as the most successful technologies in tissue engineering.
JOURNAL OF TISSUE ENGINEERING
(2023)
