Article
Geriatrics & Gerontology
Emerald Jenkins, Binu Koirala, Tamar Rodney, Ji Won Lee, Valerie T. Cotter, Sarah L. Szanton, Janiece L. Taylor
Summary: This review examined home/community-based interventions for individuals with mild cognitive impairment/early dementia and found that interventions incorporating visual/written elements, technology-based training, and caregiver support were effective in improving function. Participants simulated Instrumental Activities of Daily Living and cognitive function was assessed using both objective and subjective measures. However, gaps were identified in the literature regarding the inclusion of race/ethnicity and appropriate socioeconomic status measures.
Article
Multidisciplinary Sciences
Hiroyuki Umegaki, Yusuke Suzuki, Hitoshi Komiya, Kazuhisa Watanabe, Masaaki Nagae, Yosuke Yamada, Masafumi Kuzuya
Summary: This study investigated the association between gait speed and qualitative errors on the Clock Drawing Test (CDT) in individuals with mild cognitive impairment (MCI). The results showed that conceptual deficit (CD) type errors were negatively associated with maximum gait speed. This study further supports the clinical importance of qualitative assessments of the CDT.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Hrafnhildur Eymundsdottir, Sigurveig Sigurdardottir, Alfons Ramel, Palmi Jonsson, Vilmundur Gudnason, Lenore Launer, Milan Chang
Summary: The study found that poor social networks are associated with higher risk of declining cognitive function, mild cognitive impairment (MCI), and dementia among older adults, independent of other lifestyle factors, depression, and genetic disposition. Older adults with better social networks have lower risks of cognitive decline and MCI. The study's inclusion of relevant covariates contributes significantly to understanding cognitive aging.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychology, Clinical
Hillary J. Rouse, Brent J. Small, John A. Schinka, David A. Loewenstein, Ranjan Duara, Huntington Potter
Summary: The study found that older adults with mild behavioral impairment (MBI) performed worse on tasks of executive function, attention, and episodic memory than those without MBI. Additionally, individuals with both MCI and MBI showed significantly poorer performance on episodic memory tasks compared to those with only MCI.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Nursing
Qiao-hong Yang, Xia Lyu, Qing-ran Lin, Zi-wen Wang, Li Tang, Yu Zhao, Qi-yuan Lyu
Summary: The study evaluated the effects of a multicomponent intervention on Chinese patients with mild cognitive impairment. The results showed that the intervention had beneficial effects on cognitive function, physical function, depression symptoms, and quality of life, slowing the progression of the disease.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
Jin-Hyuck Park
Summary: This study investigates the effects of virtual shopping training on executive function and instrumental activities of daily living (IADL) in patients with mild cognitive impairment (MCI). The results suggest that virtual shopping training may be clinically beneficial in enhancing executive function and IADL in patients with MCI.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neuroimaging
Yu-Ling Chang, Ruei-Yi Chao, Yung-Chin Hsu, Ta-Fu Chen, Wen-Yih Isaac Tseng
Summary: This study investigated white matter microstructural integrity and cognitive correlates of memory awareness in older adults with or without mild cognitive impairment (MCI). While patients with MCI and poor awareness of memory deficits showed lower integrity in certain white matter fibers, the memory awareness deficits in MCI patients could not be solely explained by mnemonic anosognosia.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Aline de Moura Brasil Matos, Flavia Esper Dahy, Joao Victor Luisi de Moura, Rosa Maria Nascimento Marcusso, Andre Borges Ferreira Gomes, Fernanda Martins Maia Carvalho, Gustavo Bruniera Peres Fernandes, Alvina Clara Felix, Jerusa Smid, Jose Ernesto Vidal, Norberto Anizio Ferreira Frota, Jorge Casseb, Ava Easton, Tom Solomon, Steven S. Witkin, Camila Malta Romano, Augusto Cesar Penalva de Oliveira
Summary: This study described seven cases from Brazil of outpatients with mild or moderate COVID-19 who developed subacute cognitive disturbances after recovery. The results suggest that these cognitive symptoms might be related to SARS-CoV-2-induced damage to cortico-subcortical associative pathways, rather than solely due to inflammation and hypoxia.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Fen Wang, Xiaowei Ma, Yuqing Shi, Longfei Jia, Xiumei Zuo, Yueyi Yu, Hongmei Jin, Yi Tang, Dongmei Guo, Jianping Jia
Summary: There is evident impairment in multiple cognitive domains in adult-onset NIID, with executive dysfunction and memory deficit being common. Leukoencephalopathy may be the main cause of cognitive impairment in adult-onset NIID.
NEUROLOGICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Dharma Rane, Deba Prasad Dash, Alakananda Dutt, Anirban Dutta, Abhijit Das, Uttama Lahiri
Summary: Eye movement in response to visual tasks provides insights into the cognitive processes affected in cognitive decline. By analyzing tasks such as anti-saccades and memory guided fixation, individuals with mild cognitive impairment and dementia can be differentiated from cognitively unimpaired individuals. The results of this study suggest that anti-saccade tasks hold promise in clinical practice for professionals working with individuals with cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Chengping Hu, Ling Wang, Xudong Zhao, Binggen Zhu, Ming Tian, Hongyun Qin
Summary: Age and worsening attention, but not depression, in MCI patients were independently associated with the progression to dementia in a 6-year follow-up period. Age was identified as an independent risk factor for MCI aggravation, while attention (MoCA) was an independent protective factor for MCI progression.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Angel Nevado, David Del Rio, Maria Teresa Martin-Aragoneses, Jose M. Prados, Ramon Lopez-Higes
Summary: The study found that in mild cognitive impairment, the semantic network is preserved but the existing associations are exploited less efficiently during long-term memory search, possibly due to deficits in executive function.
Article
Geriatrics & Gerontology
Sung Hoon Kang, Jinhee Kim, Jungyeun Lee, Seong-Beom Koh
Summary: Cognitive impairment is often accompanied by gait disturbance in patients with Parkinson's disease (PD). This study aimed to investigate the association between gait parameters and mild cognitive impairment (MCI), as well as the correlation between performance on comprehensive neuropsychological tests and gait parameters in PD patients. The results showed that gait velocity and stride length were associated with MCI in PD patients, and these gait parameters were primarily influenced by attention and frontal-executive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Osamu Katayama, Sangyoon Lee, Keitaro Makino, Ippei Chiba, Seongryu Bae, Yohei Shinkai, Kenji Harada, Hiroyuki Shimada
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Geriatrics & Gerontology
Ippei Chiba, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Yohei Shinkai, Hiroyuki Shimada
Summary: The study found that an increase in visceral fat in older adults is associated with a higher risk of diabetes, but the optimal cut-off value for men remains inconclusive.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Hiroyuki Shimada, Kota Tsutsumimoto, Takehiko Doi, Sangyoon Lee, Seongryu Bae, Sho Nakakubo, Keitaro Makino, Hidenori Arai
Summary: The updated definition of sarcopenia by EWGSOP2 includes low muscle mass and quality, as well as poor physical performance as indicative of severe sarcopenia. The study found that individuals with any form of sarcopenia were at a higher risk of disability, with severe sarcopenia increasing the risk further. Grip strength and walking speed were negatively correlated with disability incidence.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Medicine, General & Internal
Takehiko Doi, Kota Tsutsumimoto, Hideaki Ishii, Sho Nakakubo, Satoshi Kurita, Hiroyuki Shimada
Summary: The study found that not driving and frailty were associated with an increased risk of disability in community-dwelling older adults.
Article
Medicine, General & Internal
Osamu Katayama, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Ippei Chiba, Kenji Harada, Yohei Shinkai, Hiroyuki Shimada
Summary: A study on community-dwelling older adults found a relationship between the frequency of walking and the number of social activities, showing that habitual walking can reduce the risk of disability, especially among older adults with fewer social activities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Hideaki Ishii, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Satoshi Kurita, Hiroyuki Shimada
Summary: This study found an association between driving cessation and physical frailty transition in community-dwelling older adults in Japan.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Environmental Sciences
Osamu Katayama, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Ippei Chiba, Kenji Harada, Yohei Shinkai, Hiroyuki Shimada
Summary: The study examined the relationship between life satisfaction, disability incidence, and mild cognitive impairment among older adults. It found that older adults with lower life satisfaction and mild cognitive impairment were more likely to develop disabilities over time.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Geriatrics & Gerontology
Yu Kume, Ayuto Kodama, Tomoko Takahashi, Sangyoon Lee, Hyuma Makizako, Tsuyosi Ono, Hiroyuki Shimada, Hidetaka Ota
Summary: The study aimed to investigate the prevalence of social frailty among older adults in a rural Japanese community and factors associated with social frailty status. The results showed that social frailty is increasing in Japanese rural areas, with social prefrailty potentially being associated with attentional function and GDS-15 scores.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Environmental Sciences
Ayuto Kodama, Yu Kume, Sangyoon Lee, Hyuma Makizako, Hiroyuki Shimada, Tomoko Takahashi, Tsuyoshi Ono, Hidetaka Ota
Summary: This study aimed to clarify the impact of social frailty in community-dwelling older adults during the COVID-19 pandemic. The findings suggest that the implementation of stay-at-home orders and increased depressive symptoms may contribute to the increase in social frailty among older individuals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Keitaro Makino, Sangyoon Lee, Seongryu Bae, Ippei Chiba, Kenji Harada, Osamu Katayama, Kouki Tomida, Masanori Morikawa, Hiroyuki Shimada
Summary: The study developed a simplified decision-tree algorithm for fall prediction with easily measurable predictors, outperforming a logistic regression model. The algorithm includes common and easily measurable fall predictors that can be implemented in clinical practice for risk stratification.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Geriatrics & Gerontology
Hiroyuki Shimada, Junichi Nitta, Hiroshi Sasaki, Taeko Watanabe, Takashi Sakamoto, Shigekazu Komoto, Hidenori Arai
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Chemistry, Analytical
Zihan Song, Hye-Jin Park, Ngeemasara Thapa, Ja-Gyeong Yang, Kenji Harada, Sangyoon Lee, Hiroyuki Shimada, Hyuntae Park, Byung-Kwon Park
Summary: The study proposes a step-counting algorithm suitable for smartphones in different carrying positions, including classification and regression algorithms, as well as a data acquisition system. Comparative results show that the algorithm provides higher accuracy in self-paced walking speed and can effectively predict step counts under different carrying positions.
Article
Medicine, General & Internal
Osamu Katayama, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Ippei Chiba, Kenji Harada, Masanori Morikawa, Kouki Tomida, Hiroyuki Shimada
Summary: Subjective cognitive decline (SCD) in older adults is associated with an increased risk of dementia, but the underlying mechanisms are not well understood. This study found that older adults with SCD have more modifiable protective factors against dementia and a lower risk of developing objective cognitive decline. These findings highlight the importance of addressing modifiable factors in preventing dementia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Hiroyuki Shimada, Takao Suzuki, Takehiko Doi, Sangyoon Lee, Sho Nakakubo, Keitaro Makino, Hidenori Arai
Summary: This study aimed to determine whether osteoporosis, osteopenia, and sarcopenia identified by simplified instruments are associated with the future incidence of disability and mortality. The results showed that osteosarcopenia was associated with an increased risk of disability and mortality. Further research is needed to implement these findings in community health activities.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Medicine, General & Internal
Seongryu Bae, Hiroyuki Shimada, Sangyoon Lee, Keitaro Makino, Ippei Chiba, Osamu Katayama, Kenji Harada, Hyuntae Park, Kenji Toba
Summary: This study investigated the trajectories of frailty and subjective cognitive decline (SCD) in older Japanese adults and found that they share a similar trajectory. Rapid progressive frailty and SCD were associated with the highest risk of depressive symptoms and slow gait speed.
JOURNAL OF CLINICAL MEDICINE
(2023)
