Article
Biochemical Research Methods
Thomas Javelle, Michel Righezza, Gregoire Danger
Summary: Analysis of organic matter from meteorites revealed significant molecular diversity among solar system objects, necessitating the development of new analytical technologies. This study utilized GC-FT-Orbitrap-MS to analyze the molecular complexity of cometary ices, demonstrating the effectiveness of a novel method for molecular identification and formula assignments.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Multidisciplinary
Guillaume Leseigneur, Jan Hendrik Bredehoeft, Thomas Gautier, Chaitanya Giri, Harald Krueger, Alexandra J. MacDermott, Uwe J. Meierhenrich, Guillermo M. Munoz Caro, Francois Raulin, Andrew Steele, Harald Steininger, Cyril Szopa, Wolfram Thiemann, Stephan Ulamec, Fred Goesmann
Summary: The Rosetta mission and the Philae lander have discovered a range of organic molecules in the nucleus of comet 67P/Churyumov-Gerasimenko. These volatile compounds represent the first raw materials present in the early Solar System.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemical Research Methods
A. Garcia, C. Serra, Q. Blancart Remaury, A. D. Garcia, M. Righezza, C. Meinert, P. Poinot, G. Danger
Summary: Gas chromatography (GC) coupled with high resolution mass spectrometry (HRMS) is essential for targeted in situ analyses of extraterrestrial samples. The study demonstrates the ability of GC-FT-orbitrap-MS to separate amino acid enantiomers and achieve lower LOD values compared to conventional GC-MS techniques. This technology development is important for future space missions.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Engineering, Environmental
Yibei Wan, Chong Xing, Xinyu Wang, Zhaomin Yang, Xiangpeng Huang, Xinlei Ge, Lin Du, Qiongqiong Wang, Huan Yu
Summary: We present a data analysis workflow for nontarget tandem high-resolution mass spectrometry (MS) that allows for the comprehensive classification of functionalized organic compounds in complex atmospheric samples. With a single mass spectrometry run, the workflow provides molecular formula, functional group, and aromaticity information for a large percentage of deprotonated and protonated molecules. The assignment and quantification of functional groups can be used to trace the sources, formation, and aging of organic compounds in the atmosphere.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Chemistry, Physical
N. Fabian Kleimeier, Ralf Kaiser
Summary: Enols are important molecules in the interstellar medium due to their reactivity and ability to provide information about molecular complexity. Research shows that enols can be formed in interstellar ices through interaction with galactic cosmic rays, playing a key role in exploring non-equilibrium chemistry in the interstellar medium. Radio telescopes like ALMA can be used to search for enols, which can serve as tracers for fundamental reaction mechanisms deep inside interstellar ices.
Article
Chemistry, Analytical
Adam L. Hollerbach, Randolph Norheim, Pearl Kwantwi-Barima, Richard D. Smith, Yehia M. Ibrahim
Summary: Ion mobility spectrometry with structures for lossless ion manipulations (SLIM-IMS) offers unprecedented ion path lengths and resolving powers. The development of the 1 m miniature SLIM module based on multilevel SLIM technology has enabled high resolution IMS measurements over the entire mobility range. Comparisons with drift tube IMS-MS show that miniSLIM achieves higher resolving power and allows for single-pass separation of the entire ion mobility range.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Gianluca Trifiro, Richard York, Nicholle G. A. Bell
Summary: This study used multiple analytical techniques to examine a peat core from Flow Country, Scotland, revealing new insights into molecular signatures in peat layers. The research identified the impact of core depth and water table fluctuations on peat molecular composition.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaoyu Zhou, Zhuofan Wang, Jingjin Fan, Zheng Ouyang
Summary: Ion mobility is utilized in mass spectrometers for analyzing the structure of biomolecules. Researchers demonstrate that ion mobility analysis in an ion trap with ultra-high fields can achieve resolutions over 10,000 for isomer separation, as shown for disaccharide, phospholipid, and peptide isomers. Elucidating complex structures of biomolecules is crucial in chemistry and life sciences. In the last decade, ion mobility coupled with mass spectrometry has become a unique tool for distinguishing isomers and isoforms of biomolecules. This study presents a concept for ion mobility analysis using an ion trap, enabling ultra-high field isomer separation and achieving resolutions over 10,000. The potential of this technology is demonstrated for analyzing isomers of disaccharides, phospholipids, and peptides with post-translational modifications.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Italo de Oliveira Braga, Thalliton Luiz Carvalho da Silva, Vivianny Nayse Belo Silva, Jorge Candido Rodrigues Neto, Jose Antonio de Aquino Ribeiro, Patricia Verardi Abdelnur, Carlos Antonio Ferreira de Sousa, Manoel Teixeira Souza Jr
Summary: The multipurpose tree Gliricidia sepium is able to adapt to high salt stress, and the phenylpropanoid biosynthesis pathway plays a crucial role in its response to salt stress. In-depth metabolomics analysis revealed that these plants employ two salt-excluding mechanisms and that the phenylpropanoid biosynthesis pathway is involved in both short-term and long-term adaptation response. The roots metabolome analysis identified 11 affected metabolic pathways, and further analysis suggested the accumulation of lignin, phytosterols, and lysine biosynthesis as potential mechanisms promoting the adaptation response.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Spectroscopy
Sungjune Kim, Donghwi Kim, Maeng-Joon Jung, Sunghwan Kim
Summary: With the growing environmental and climate changes globally, there is an increasing interest in the molecular-level understanding of environmental organic compound mixtures. Studies have shown that ultrahigh resolution and sub-ppb level mass accuracy are crucial for analyzing complex environmental organic molecule mixtures, achievable using FT-ICR MS. However, challenges in sample preparation, ionization, structural identification, chromatographic separation, and data interpretation remain to be overcome.
MASS SPECTROMETRY REVIEWS
(2022)
Article
Chemistry, Analytical
Chao Liu, Jiafa Zeng, Pablo Sinues, Mingliang Fang, Zhen Zhou, Xue Li
Summary: SESI-HRMS is a direct mass spectrometry technique that can identify trace VOCs in real time, but further development of absolute quantification methods is needed.
ANALYTICA CHIMICA ACTA
(2021)
Article
Engineering, Environmental
Xiaoxiao Wang, Guodong Cao, Zhiyi Yang, Hongzhi Zhao, Zongwei Cai
Summary: In this study, the formation of deoxyribonucleoside/ribonucleoside adducts from quinone metabolites of BPF was investigated. The results showed that BPF-quinone can covalently bind to both deoxyribonucleosides and ribonucleosides, providing important information for the investigation of BPF genotoxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Eleni A. Kisty, Emma C. Saart, Eranthie Weerapana
Summary: The mitochondrion is a crucial component in cellular energy production and oxidoregulation. This study identified redox-sensitive cysteines on mitochondrial proteins through the use of mitochondrial enrichment and redox proteomics techniques. The results revealed both known and unknown cysteines on diverse mitochondrial proteins that are responsive to endogenous and exogenous reactive oxygen species.
Review
Medical Laboratory Technology
Kenichi Tamama
Summary: Drugs of abuse testing is commonly used in clinical and forensic settings, with urine being the preferred specimen type but other emerging types include saliva, sweat, hair, and meconium. Liquid chromatography-tandem mass spectrometry (LC-tandem-MS) has become the new gold standard for confirmatory drug testing due to its ability to analyze a wider range of analytes compared to gas chromatography-mass spectrometry (GC-MS). Technical advancements such as high-resolution mass spectrometry and miniature ambient ionization mass spectrometry have improved the speed and efficiency of drugs of abuse testing.
CLINICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Joshua H. Marks, Jia Wang, N. Fabian Kleimeier, Andrew M. Turner, Andre K. Eckhardt, Ralf I. Kaiser
Summary: Glycinal and acetamide, simple molecular building blocks of biomolecules, are formed in low temperature interstellar ices through radical-radical reactions and tautomerization. These findings provide insights into the formation of complex organics in cold molecular cloud environments and their relevance to contemporary biomolecules in deep space.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
D. Sundelin, D. Ascenzi, V. Richardson, C. Alcaraz, M. Polasek, C. Romanzin, R. Thissen, P. Tosi, J. Zabka, W. Geppert
Summary: Experimental and theoretical studies were conducted on the reactivity of methanimine and aminomethylene with ethene. Results showed differences in reactivity between the two isomers, with H-elimination being the main product for both.astrochemical implications of the results were briefly addressed.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Chemistry, Physical
V. Richardson, C. Alcaraz, W. D. Geppert, M. Polasek, C. Romanzin, D. Sundelin, R. Thissen, P. Tosi, J. Zabka, D. Ascenzi
Summary: Experimental and theoretical studies were conducted on the reactions of isomeric radical cations H2CNH·+ and HCNH2·+ with CH4, resulting in the formation of H2CNH2+ and CH3· as products. The study also briefly discussed the possible presence of methanimine in Titan's atmosphere, based on atmospheric models and mass spectrometric data from the Cassini mission.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Astronomy & Astrophysics
Junko Isa, Francois-regis Orthous-Daunay, Pierre Beck, Christopher D. K. Herd, Veronique Vuitton, Laurene Flandinet
Summary: The study found that the mass distribution of SOM in Tagish Lake meteorite fragments can be well fit by the Schulz-Zimm model, indicating the complex nature of primordial SOM. This suggests that aqueous reactions on asteroids are not necessary for cultivating complex SOM.
ASTROPHYSICAL JOURNAL LETTERS
(2021)
Article
Chemistry, Physical
Imene Derbali, Roland Thissen, Christian Alcaraz, Claire Romanzin, Emilie-Laure Zins
Summary: The study investigated the possible formation of a peptide-like bond from the reaction between acetic acid and methylamine in the interstellar medium. Experimental results showed that charge transfer, proton transfer, and dissociation processes were the main reaction pathways, while a weak C(O)-N bond formation process was also identified. Theoretical simulations using density functional theory were consistent with the experimental data, confirming the reactivity and barrier heights of the reaction.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Geochemistry & Geophysics
Katharina Kaiser, Fabian Schulz, Julien F. Maillard, Felix Hermann, Iago Pozo, Diego Pena, H. James Cleaves, Aaron S. Burton, Gregoire Danger, Carlos Afonso, Scott Sandford, Leo Gross
Summary: Researchers used high-resolution atomic force microscopy to atomically resolve individual molecules from Murchison meteorite samples. They also proposed a method for extracting and preparing meteorite samples for investigation. By processing the samples, they were able to increase the fraction of molecules that could be resolved by atomic force microscopy and identify organic constituents and molecular moieties.
METEORITICS & PLANETARY SCIENCE
(2022)
Article
Chemistry, Analytical
Coline Serra, Justin Lange, Quentin Blancart Remaury, Ramzi Timoumi, Gregoire Danger, Boris Laurent, Laurent Remusat, Claude Geffroy Rodier, Pauline Poinot
Summary: Molecular identification is a crucial issue in astrobiology, playing a key role in investigating the origins of life on Earth and the potential spread of extraterrestrial organic matter. However, the low concentration of molecules in celestial bodies presents significant challenges for this project. This study proposes a novel integrative analytical workflow to enhance the comprehensive analysis of organic markers in these objects.
Article
Astronomy & Astrophysics
Laura Tenelanda-Osorio, Alexis Bouquet, Thomas Javelle, Olivier Mousis, Fabrice Duvernay, Gregoire Danger
Summary: Laboratory experiments show that methanol ice can produce different volatile organic compounds under different UV irradiation doses and temperatures. With increasing UV irradiation, the production of heavier complex organic molecules increases. Ketones and esters are formed at the earliest stages of irradiation, while aldehydes are formed before their alcohol counterparts. Ethers seem to be precursors of a large set of complex organic molecules.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Geochemistry & Geophysics
B. Laurent, J. Maillard, C. Afonso, G. Danger, P. Giusti, L. Remusat
Summary: Primitive carbonaceous chondrites exhibit a high diversity in terms of their organic content and hydrothermal alteration. This study utilized laser desorption ionization Fourier transform ion cyclotron resonance mass spectrometry (LDI-FTICR-MS) to analyze the macromolecular carbon of carbonaceous chondrites. The results show that the abundance of chemical families is correlated to the degree of aqueous alteration, with weakly altered chondrites retaining the highest chemical heterogeneity. Moreover, similarities between the insoluble organic matter of Orgueil and Tarda suggest that they originated from the outer belt region. The application of FTICR-MS on returned asteroidal samples could provide insights into the origin and evolution of organic compounds in the early solar system.
GEOCHEMICAL PERSPECTIVES LETTERS
(2022)
Article
Chemistry, Analytical
Alexander Ruf, Gregoire Danger
Summary: This article presents a method for generating and analyzing complex astrochemical data using a data-driven and unsupervised approach. The results demonstrate that this method significantly improves the structural characterization of large complex organic molecules in interstellar ice analogs.
ANALYTICAL CHEMISTRY
(2022)
Article
Astronomy & Astrophysics
Gregoire Danger, Alexander Ruf, Thomas Javelle, Julien Maillard, Vassilissa Vinogradoff, Carlos Afonso, Isabelle Schmitz-Afonso, Laurent Remusat, Zelimir Gabelica, Philippe Schmitt-Kopplin
Summary: This study investigates the relationship between soluble and insoluble organic matter in laboratory experiments and meteorites, providing new insights into the evolution of organic matter in the Solar System. Through analysis of their chemical fingerprints and elemental ratios, the study reveals a connection between the two classes of organic matter. The results also demonstrate the complexity of organic matter formation in meteorites and suggest the influence of factors such as aqueous alteration.
ASTRONOMY & ASTROPHYSICS
(2022)
Article
Biochemical Research Methods
A. Garcia, C. Serra, Q. Blancart Remaury, A. D. Garcia, M. Righezza, C. Meinert, P. Poinot, G. Danger
Summary: Gas chromatography (GC) coupled with high resolution mass spectrometry (HRMS) is essential for targeted in situ analyses of extraterrestrial samples. The study demonstrates the ability of GC-FT-orbitrap-MS to separate amino acid enantiomers and achieve lower LOD values compared to conventional GC-MS techniques. This technology development is important for future space missions.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Multidisciplinary
Coline Serra, Vassilissa Vinogradoff, Pauline Poinot, Quentin Blancart Remaury, Fabrice Duvernay, Louis Le Sergeant d'Hendecourt, Gregoire Danger, Philippe Claeys, Steven Goderis, Philippe Schmitt-Kopplin
Summary: This study characterizes the soluble organic matter (SOM) of Asuka 12236, one of the most primitive members of the CM group, and compares it with the SOM from other CM chondrites. The results show that organic compounds may be transformed more rapidly than minerals during hydrothermal alteration, and this organic matter evolution depends on water content, temperature, and pressure. Additional laboratory experimentation is needed to better understand the impact of aqueous alteration on organic matter in chondrites.
ACS EARTH AND SPACE CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Orion Farr, Nil Gaudu, Gregoire Danger, Michael J. Russell, Daniel Ferry, Wolfgang Nitschke, Simon Duval
Summary: The shared coordination geometries between metal ions in reactive minerals and enzymatic metal cofactors suggest a similarity in mechanisms and evolution between biological metabolism and non-biological chemical mineralogy. By simulating the oxidation reaction of reactive minerals in the presence of seawater, we found that methane oxidation yields not only methanol but also other organic compounds. This discovery reveals a previously unidentified carbon cycling mechanism in modern and ancient environments, and provides insights into the synthesis of organic compounds necessary for the emergence of life.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Astronomy & Astrophysics
O. Mousis, A. Bouquet, Y. Langevin, N. Andre, H. Boithias, G. Durry, F. Faye, P. Hartogh, J. Helbert, L. Iess, S. Kempf, A. Masters, F. Postberg, J. -B. Renard, P. Vernazza, A. Vorburger, P. Wurz, D. H. Atkinson, S. Barabash, M. Berthomier, J. Brucato, M. Cable, J. Carter, S. Cazaux, A. Coustenis, G. Danger, V. Dehant, T. Fornaro, P. Garnier, T. Gautier, O. Groussin, L. Z. Hadid, J. -C. Ize, I. Kolmasova, J. -P. Lebreton, S. Le Maistre, E. Lellouch, J. I. Lunine, K. E. Mandt, Z. Martins, D. Mimoun, Q. Nenon, G. M. Munoz Caro, P. Rannou, H. Rauer, P. Schmitt-Kopplin, A. Schneeberger, M. Simons, K. Stephan, T. Van Hoolst, J. Vaverka, M. Wieser, L. Woerner
Summary: Enceladus, a moon of Saturn, has an internal water ocean and expels ocean material into space. The Moonraker mission aims to investigate the composition of the plume formed by the ocean jets to understand the moon's habitability and origin. This proposed mission will use advanced instruments to pave the way for future landed missions.
PLANETARY SCIENCE JOURNAL
(2022)
Article
Chemistry, Analytical
Alexander Ruf, Gregoire Danger
Summary: The mol2net method has been used to generate and analyze molecular networks of complex astrochemical data in an unsupervised and data-driven manner. The study significantly refines the structural characterization of large complex organic molecules in interstellar ice analogs, providing additional information on key transformations and molecular structures.
ANALYTICAL CHEMISTRY
(2022)
Article
Geochemistry & Geophysics
Xinze Lu, Geoffrey J. Gilleaudeau, Brian Kendall
Summary: The Late Ordovician mass extinction is the first major extinction event in the Phanerozoic, but the reasons for the decline in global biodiversity before the extinction are not well understood.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2024)
Article
Geochemistry & Geophysics
Junyao Kang, Daniel D. Gregory, Benjamin Gill, Shiqiang Huang, Changxin Lai, Zhaoshan Chang, Huan Cui, Ivan Belousov, Shuhai Xiao
Summary: Sedimentary pyrite is an important geological archive, but it can be altered by diagenetic and hydrothermal processes. This study successfully trained machine learning algorithms to distinguish pyrite origins using trace element data. The approach was validated and applied to identify the origins of pyrite in two sedimentary successions in South China.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2024)