4.7 Letter

Integration between oncology and palliative care: does one size fit all?

Journal

ANNALS OF ONCOLOGY
Volume 27, Issue 3, Pages 549-549

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdv582

Keywords

-

Categories

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Oncology

Neurological and vascular complications of primary and secondary brain tumours: EANO-ESMO Clinical Practice Guidelines for prophylaxis, diagnosis, treatment and follow-up

P. Roth, A. Pace, E. Le Rhun, M. Weller, C. Ay, E. Cohen-Jonathan Moyal, M. Coomans, R. Giusti, K. Jordan, R. Nishikawa, F. Winkler, J. T. Hong, R. Ruda, S. Villa, M. J. B. Taphoorn, W. Wick, M. Preusser

ANNALS OF ONCOLOGY (2021)

Review Oncology

Standard of Care and Promising New Agents for the Treatment of Mesenchymal Triple-Negative Breast Cancer

Silvia Mezi, Andrea Botticelli, Giulia Pomati, Bruna Cerbelli, Simone Scagnoli, Sasan Amirhassankhani, Giulia d'Amati, Paolo Marchetti

Summary: The mesenchymal triple negative breast cancer subtype is characterized by the expression of specific genes and an immunosuppressive microenvironment. Research focuses on the intracellular pathways involved in tumorigenesis and cancer progression, as well as strategies to address immune evasion mechanisms.

CANCERS (2021)

Article Oncology

Clinical outcomes of NSCLC patients experiencing early immune-related adverse events to PD-1/PD-L1 checkpoint inhibitors leading to treatment discontinuation

Marco Russano, Alessio Cortellini, Raffaele Giusti, Alessandro Russo, Federica Zoratto, Francesca Rastelli, Alain Gelibter, Rita Chiari, Olga Nigro, Michele De Tursi, Sergio Bracarda, Stefania Gori, Francesco Grossi, Melissa Bersanelli, Lorenzo Calvetti, Vincenzo Di Noia, Mario Scartozzi, Massimo Di Maio, Paolo Bossi, Alfredo Falcone, Fabrizio Citarella, Francesco Pantano, Corrado Ficorella, Marco Filetti, Vincenzo Adamo, Enzo Veltri, Federica Pergolesi, Mario Alberto Occhipinti, Linda Nicolardi, Alessandro Tuzi, Pietro Di Marino, Serena Macrini, Alessandro Inno, Michele Ghidini, Sebastiano Buti, Giuseppe Aprile, Eleonora Lai, Marco Audisio, Salvatore Intagliata, Riccardo Marconcini, Davide Brocco, Giampiero Porzio, Marta Piras, Erika Rijavec, Francesca Simionato, Clara Natoli, Marcello Tiseo, Bruno Vincenzi, Giuseppe Tonini, Daniele Santini

Summary: The study did not find a survival benefit in patients experiencing severe irAEs compared to the control group. However, early and severe irAEs may indicate immune anti-tumor activation, and there was a significant association with first-line immune checkpoint inhibitors treatment and good patient performance status. Further research is needed on risk prediction and management of serious and early irAEs in NSCLC patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

Article Oncology

A 17-Gene Expression Signature for Early Identification of Poor Prognosis in Clear Cell Renal Cell Carcinoma

Maria Bassanelli, Marina Borro, Michela Roberto, Diana Giannarelli, Silvana Giacinti, Simona Di Martino, Anna Ceribelli, Andrea Russo, Annamaria Aschelter, Stefania Scarpino, Andrea Montori, Edoardo Pescarmona, Silverio Tomao, Maurizio Simmaco, Francesco Cognetti, Michele Milella, Paolo Marchetti

Summary: Our analysis identified a 17-gene expression signature that can predict the prognosis of patients with clear cell renal cancer. These genomic signatures have a significant correlation with overall survival and could potentially be used as biomarkers for prognosis prediction in ccRCC.

CANCERS (2022)

Article Oncology

Patients' Satisfaction with Breakthrough Cancer Pain Therapy: A Secondary Analysis of IOPS-MS Study

Marco Mazzotta, Marco Filetti, Marta Piras, Sebastiano Mercadante, Paolo Marchetti, Raffaele Giusti

Summary: This study aims to identify factors that can predict patients' satisfaction with pain relief for breakthrough cancer pain (BTcP). The results showed that younger age, non metastatic cancer stage, high Karnofsky performance status, absence of anticancer treatment, and high BTcP interference in activities of daily living were positively correlated with dissatisfaction.

CANCER MANAGEMENT AND RESEARCH (2022)

Review Oncology

Definition of High-Risk Early Hormone-Positive HER2-Negative Breast Cancer: A Consensus Review

Mattia Garutti, Gaia Griguolo, Andrea Botticelli, Giulia Buzzatti, Carmine De Angelis, Lorenzo Gerratana, Chiara Molinelli, Vincenzo Adamo, Giampaolo Bianchini, Laura Biganzoli, Giuseppe Curigliano, Michelino De Laurentiis, Alessandra Fabi, Antonio Frassoldati, Alessandra Gennari, Caterina Marchio, Francesco Perrone, Giuseppe Viale, Claudio Zamagni, Alberto Zambelli, Lucia Del Mastro, Sabino De Placido, Valentina Guarneri, Paolo Marchetti, Fabio Puglisi

Summary: Breast cancer is a leading cause of cancer-related morbidity and mortality in women worldwide, and estimating the risk of relapse for individual cases remains challenging. The IRIDE working group reviewed literature evidence to identify the relevant features predicting relapse in hormone receptor-positive/HER2-negative early breast cancer, aiming to provide guidance for clinicians in managing these cases effectively.

CANCERS (2022)

Article Oncology

The Impact of the Hippo Pathway and Cell Metabolism on Pathological Complete Response in Locally Advanced Her2+Breast Cancer: The TRISKELE Multicenter Prospective Study

Eriseld Krasniqi, Francesca Sofia Di Lisa, Anna Di Benedetto, Maddalena Barba, Laura Pizzuti, Lorena Filomeno, Cristiana Ercolani, Nicola Tinari, Antonino Grassadonia, Daniele Santini, Mauro Minelli, Filippo Montemurro, Maria Agnese Fabbri, Marco Mazzotta, Teresa Gamucci, Giuliana D'Auria, Claudio Botti, Fabio Pelle, Flavia Cavicchi, Sonia Cappelli, Federico Cappuzzo, Giuseppe Sanguineti, Silverio Tomao, Andrea Botticelli, Paolo Marchetti, Marcello Maugeri-Sacca, Ruggero De Maria, Gennaro Ciliberto, Francesca Sperati, Patrizia Vici

Summary: This study investigated the impact of immunohistochemical expression of Hippo pathway transducers and cell metabolism regulators on the outcome of neoadjuvant treatment in Her2+ breast cancer patients. The results showed that low expression of TAZ, especially when combined with low expression of YAP and HMGCR and high expression of SCD1, may be a negative predictor of treatment response. However, further studies with a larger sample size are needed to validate these findings.

CANCERS (2022)

Article Biochemistry & Molecular Biology

Genomic and Immune Approach in Platinum Refractory HPV-Negative Head and Neck Squamous Cell Carcinoma Patients Treated with Immunotherapy: A Novel Combined Profile

Silvia Mezi, Giulia Pomati, Ilaria Grazia Zizzari, Alessandra Di Filippo, Bruna Cerbelli, Alessio Cirillo, Giulia Fiscon, Sasan Amirhassankhani, Valentino Valentini, Marco De Vincentiis, Alessandro Corsi, Cira Di Gioia, Vincenzo Tombolini, Carlo Della Rocca, Antonella Polimeni, Marianna Nuti, Paolo Marchetti, Andrea Botticelli

Summary: This study evaluated the combined role of genomic and immune profiles in PR/HNSCC patients treated with anti-PD-1 nivolumab. The results showed that some patients benefited from the treatment, while others experienced early progression. Furthermore, specific gene mutations and immune features were found to be associated with treatment response.

BIOMEDICINES (2022)

Article Oncology

Supportive therapies in the prevention of chemotherapy-induced febrile neutropenia and appropriate use of granulocyte colony-stimulating factors: a Delphi consensus statement

Vincenzo Adamo, Lorenzo Antonuzzo, Marco Danova, Michelino De Laurentiis, Paolo Marchetti, Carmine Pinto, Giovanni Rosti

Summary: This study aims to improve adherence to guideline recommendations for the prevention of febrile neutropenia and to enhance patient care.

SUPPORTIVE CARE IN CANCER (2022)

Article Oncology

The Impact of NUTRItional Status at First Medical Oncology Visit on Clinical Outcomes: The NUTRIONCO Study

Maurizio Muscaritoli, Alessandra Modena, Matteo Valerio, Paolo Marchetti, Roberto Magarotto, Silvia Quadrini, Filomena Narducci, Giuseppe Tonini, Teresa Grassani, Luigi Cavanna, Camilla Di Nunzio, Chiara Citterio, Marcella Occelli, Antonia Strippoli, Bruno Chiurazzi, Antonio Frassoldati, Giuseppe Altavilla, Antonio Lucenti, Fabrizio Nicolis, Stefania Gori

Summary: Malnutrition and cachexia in cancer patients have a negative impact on treatment, outcomes, quality of life, and survival. However, the risk of malnutrition and cachexia is still overlooked in cancer patients. A study revealed that 51% of patients already had nutritional deficiencies at their first oncology visit. These findings emphasize the importance of proactive, early management of malnutrition in cancer patients.

CANCERS (2023)

Article Health Care Sciences & Services

Palliative sedation and time to death in home palliative care: retrospective analysis

Daniele Marinelli, Giulio Ravoni, Maria Fusilli, Emilia Colpani, Marco Filetti, Daniele Santini, Giampiero Porzio, Raffaele Giusti

Summary: This study examined time to death and rates of palliative sedation in home palliative care for patients with advanced cancer. The results showed that Eastern Cooperative Oncology Group performance status, sex, and anticancer treatment significantly influenced survival time. Among the cohort, 38% of patients received home palliative sedation for refractory symptoms, primarily delirium and dyspnoea.

BMJ SUPPORTIVE & PALLIATIVE CARE (2023)

Letter Health Care Sciences & Services

Medical oncologists and supportive/palliative care education: prevention of fragmented care'

Raffaele Giusti, Giulio Ravoni, Giampiero Porzio

BMJ SUPPORTIVE & PALLIATIVE CARE (2023)

Letter Health Care Sciences & Services

Training and telemedicine: the key to the palliative medicine specialist shortage?

Giulio Ravoni, Maria Fusilli, Giulia Parretti, Emilia Colpani, Giampiero Porzio, Giuseppe Spinelli, Daniele Marinelli, Raffaele Giusti

BMJ SUPPORTIVE & PALLIATIVE CARE (2023)

Article Medicine, General & Internal

Impact of influenza vaccination on survival of patients with advanced cancer receiving immune checkpoint inhibitors (INVIDIa-2): final results of the multicentre, prospective, observational study

Melissa Bersanelli, Elena Verzoni, Alessio Cortellini, Raffaele Giusti, Lorenzo Calvetti, Paola Ermacora, Marilena Di Napoli, Annamaria Catino, Valentina Guadalupi, Giorgia Guaitoli, Vieri Scotti, Francesca Mazzoni, Antonello Veccia, Pamela Francesca Guglielmini, Fabiana Perrone, Marco Maruzzo, Ernesto Rossi, Chiara Casadei, Vincenzo Montesarchio, Francesco Grossi, Mimma Rizzo, Maria Grazia Travagliato Liboria, Manlio Mencoboni, Fable Zustovich, Lucia Fratino, Caterina Accettura, Saverio Cinieri, Andrea Camerini, Mariella Soraru, Paolo Andrea Zucali, Serena Ricciardi, Antonio Russo, Giorgia Negrini, Maria Chiara Banzi, Gaetano Lacidogna, Giuseppe Fornarini, Letizia Laera, Claudia Mucciarini, Matteo Santoni, Claudia Mosillo, Andrea Bonetti, Lucia Longo, Donata Sartori, Editta Baldini, Michele Guida, Mauro Iannopollo, Roberto Bordonaro, Maria Francesca Morelli, Pierosandro Tagliaferri, Massimiliano Spada, Anna Ceribelli, Rosa Rita Silva, Franco Nole, Giordano Beretta, Petros Giovanis, Daniele Santini, Stefano Luzi Fedeli, Oriano Nanni, Evaristo Maiello, Roberto Labianca, Carmine Pinto, Alberto Clemente, Michele Tognetto, Ugo De Giorgi, Sandro Pignata, Massimo Di Maio, Sebastiano Buti, Diana Giannarelli

Summary: The INVIDIa-2 study found that influenza vaccination has a positive impact on the outcomes of advanced cancer patients receiving immune checkpoint inhibitor therapy. The vaccination was associated with improved overall survival, progression-free survival, and disease-control rate. These findings support the recommendation of vaccination in cancer patients and suggest a potential synergy between antiviral and antitumor immunity. Rating: 8/10.

ECLINICALMEDICINE (2023)

Article Oncology

A Regional Survey on Merkel Cell Carcinoma: A Plea for Uniform Patient Journey Modeling and Diagnostic-Therapeutic Pathway

Michela Roberto, Andrea Botticelli, Alessio Caggiati, Alberto Chiriatti, Carlo Della Rocca, Virginia Ferraresi, Felice Musicco, Giovanni Pellacani, Paolo Marchetti

Summary: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that affects elderly and immunosuppressed individuals in sun-exposed areas. A survey conducted in the Lazio region, Italy, reveals variations in awareness and knowledge of MCC among different medical specialties. Improving communication and establishing specialized centers can enhance the diagnostic and therapeutic pathways for MCC patients.

CURRENT ONCOLOGY (2022)

No Data Available