Journal
JOURNAL OF VIROLOGY
Volume 90, Issue 6, Pages 3257-3261Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03198-15
Keywords
-
Categories
Funding
- Ministry of Health, Labor, and Welfare of Japan
Ask authors/readers for more resources
The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available