Journal
GENOMICS
Volume 100, Issue 4, Pages 245-251Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2012.07.001
Keywords
aCGH; Copy number variation; Major Histocompatibility Complex; Oryctolagus cuniculus
Funding
- University of Bologna RFO
- Fondazione Edmund Mach funds
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The European rabbit (Oryctolagus cuniculus) is relevant in a large spectrum of fields: it is a livestock, a pet, a biomedical model and a biotechnology tool, a wild resource and a pest. The sequencing of the rabbit genome has opened new perspectives to study this lagomorph at the genome level. We herein investigated for the first time the O. cuniculus genome by array comparative genome hybridization (aCGH) and established a first copy number variation (CNV) genome map in this species comprising 155 copy number variation regions (CNVRs: 95 gains, 59 losses, 1 with both gain and loss) covering similar to 0.3% of the OryCun2.0 version. About 50% of the 155 CNVRs identified spanned 139 different protein coding genes, 110 genes of which were annotated or partially annotated (including Major Histocompatibility Complex genes) with 277 different gene ontology terms. Many rabbit CNVRs might have a functional relevance that should be further investigated. (C) 2012 Elsevier Inc. All rights reserved.
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