Article
Oncology
Weiqian Guo, Xiaomin Zheng, Lei Hua, Xianbin Zheng, Yangyang Zhang, Bin Sun, Zhenchao Tao, Jin Gao
Summary: Differentiated expressed genes for nasopharyngeal carcinoma were identified and potential biomarkers were explored through bioinformatical analysis. The core genes screened may serve as prognostic and diagnostic biomarkers for NPC.
Article
Genetics & Heredity
Weitao Hu, Taiyong Fang, Xiaoqing Chen
Summary: This study identified DEGs associated with ulcerative colitis (UC) using bioinformatics analysis, providing potential diagnostic and therapeutic targets. The DEGs, hub genes and miRNAs identified may serve as biomarkers for UC, but further research is needed to understand their biological roles in the disease.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Reem Altaf, Umair Ilyas, Anmei Ma, Meiqi Shi
Summary: In this study, bioinformatics analysis was used to evaluate four datasets for differentially expressed genes (DEGs) associated with non-small cell lung cancer (NSCLC). Ten significant DEGs were identified and their expression was validated. Gene-gene and drug-gene network analysis revealed important interactions and potential drug targets. This study highlights the importance of systemic genetics in identifying potential targeted therapies for NSCLC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Seung-Hoon Lee, Na Rae Park, Jung-Eun Kim
Summary: In this study, gene expression changes during megakaryocyte maturation were analyzed using the GeneChip microarray technology, and functional classification and protein interaction analysis of the differentially expressed genes were performed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Bokang Ko, Jeremy M. Van Raamsdonk
Summary: Gene expression studies provide valuable insights into biological processes, such as aging. This study shows that pooling individual RNA samples before sequencing can yield similar results as sequencing them individually, reducing the cost of experiments. Analysis of gene expression changes across the genome is a powerful and unbiased tool for understanding molecular mechanisms.
Article
Multidisciplinary Sciences
Changsheng Guo, Yuanqing Hua, Zuanhao Qian
Summary: This study identified differentially expressed lncRNAs and genes in Kawasaki disease (KD), as well as constructed ceRNA networks involving miRNAs and mRNAs. The study found specific lncRNAs (PSORS1C3, LINC00999, SNHG5) and genes (GATA3, SOD2, MAPK14, PPARG) that may play a key role in the pathogenesis and development of KD. Validation in a separate dataset showed that intravenous immunoglobulin treatment alleviated the deregulated RNA profiles in KD patients.
Article
Surgery
Chao Xu, TianYu Liu, YunPeng Zhang, Yi Feng
Summary: In this study, bioinformatics analysis was conducted to identify mechanisms for more effective treatments of neuropathic pain. Seven hub genes and potential targeting miRNA related to the pathogenesis of neuropathic pain were identified, expanding understanding of the mechanism and facilitating treatment development.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Engineering, Chemical
Yuan-Shuo Hsueh, Hui Hua Chang, Shun-Yao Ko, Yi-Pai Lin, Wei-Yu Lin
Summary: Chronic partial bladder outlet obstruction (PBOO) can lead to bladder fibrosis, and gene expression alterations may play a significant role in its pathogenesis.
Article
Biochemistry & Molecular Biology
Xiaodong Chen, Hao Sun, Bin Zhao, Rui Wang, Changhao Ji, Bin Zhu
Summary: RNA-Seq was used to identify 13,172 differentially expressed genes (DEGs) in barley tissues, with more up-regulated DEGs observed in leaf vs spike and stem vs spike comparisons, while down-regulated DEGs were dominant in stem vs leaf comparison. 47 DEGs were annotated to the monolignol pathway, of which six were candidate genes regulating lignin biosynthesis. qRT-PCR assay validated the expression profiles of the six candidate genes, with four genes potentially positively regulating lignin biosynthesis, and the other two genes possibly having reverse effects. These findings provide target genes for further investigations on molecular regulatory mechanisms of lignin biosynthesis and genetic resources for improvement of forage quality in barley breeding.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Nan Li, Ming Liu, Xiaohui Cao, Wei Li, Yunfang Li, Zongmao Zhao
Summary: In this study, differentially expressed genes in NSCLC tissues with or without bone metastases were identified, with COL6A1 being chosen as the target gene. Functional experiments demonstrated that overexpression of COL6A1 promoted the proliferation and invasion of NSCLC cells, while knockdown inhibited these processes. Moreover, COL6A1 also affected the adhesion ability of cancer cells to osteoblasts. These findings suggest that COL6A1 may serve as a potential diagnostic marker and therapeutic target for bone metastasis in NSCLC.
Article
Plant Sciences
Jing-xuan Wang, Bo Wang, Lu-bin Cui, Hao Xie, Run-zhi Li, Cheng Wang, Zhang-jie Nan, Yu-shu Liu, Jing-yu Ma, Yun-jin Sun, Wei-yu Li
Summary: This study identified key genes involved in aluminum resistance in soybeans, which are crucial for functions such as cell junction and phenylpropanoid biosynthesis, providing important information for breeding aluminum-resistant varieties.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2021)
Article
Genetics & Heredity
Huaifeng Liu, Yu Gao, Shangshang Hu, Zhengran Fan, Xianggang Wang, Shujing Li
Summary: The study identified 563 DERGs in LIHC patients, with some genes significantly associated with survival rate. Consistent results from bioinformatics analysis and cell experiments showed that abnormal expression of CSNK1D, CSNK1E, and NPAS2 genes were closely related to the survival rate of LIHC patients.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Yanliang Cai, Weitao Hu
Summary: This study identified potential diagnostic and treatment biomarkers for Kawasaki disease using bioinformatics analysis. A total of 269 differentially expressed genes, 9 hub genes, and 3 miRNAs were identified. These genes are involved in the immune and inflammatory responses associated with Kawasaki disease.
SCIENTIFIC REPORTS
(2022)
Article
Education, Scientific Disciplines
Zhongxiang Du, Xiajun Zhang, Weiya Gao, Jie Yang
Summary: This study analyzed differentially expressed genes in gastric cancer patients and identified three genes (PCCA, ECHS1, and HADH) with prognostic value. ECHS1 and HADH were significantly associated with disease-free survival, while PCCA was significantly correlated with overall survival rate. These genes may serve as new biomarkers for predicting the prognosis of gastric cancer.
Article
Genetics & Heredity
Guofeng Zhou, Shaoyan Sun, Qiuyue Yuan, Run Zhang, Ping Jiang, Guangyu Li, Yong Wang, Xiao Li
Summary: Heart failure with preserved ejection fraction (HFpEF) is a complex disease characterized by dysfunctions in the heart, adipose tissue, and cerebral arteries. This study utilized a multilevel comparative framework to investigate the shared and unique pathological features among the three tissues in HFpEF, revealing potential therapeutic targets for personalized medicine.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Zutan Li, Bingbing Jin, Jingya Fang
Summary: In this study, we propose MetaAc4C, an advanced deep learning model for accurate identification of N4-acetylcytidine (ac4C) sites using pre-trained BERT and various optimization techniques. By adapting generative adversarial networks to address data imbalance and augmenting training RNA samples, our model outperforms existing methods in terms of ACC, MCC, and AUROC.