Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 21, Pages 11150-11158Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01370-15
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Funding
- Swiss National Science Foundation [31003A_144094/1]
- Swiss National Science Foundation (SNF) [31003A_144094] Funding Source: Swiss National Science Foundation (SNF)
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Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.
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