Letter
Medicine, General & Internal
Aileen S. Ahiskali, Dimitri M. Drekonja, Jonathan D. Alpern
Summary: This study examines the prevalence of conflicts of interest (COI) among Infectious Diseases Society of America guideline authors regarding guideline-recommended drugs, and evaluates their compliance with guidelines from the Council on Medical Specialty Societies and Institute of Medicine.
Article
Immunology
Peter J. Krause, Paul G. Auwaerter, Raveendhara R. Bannuru, John A. Branda, Yngve T. Falck-Ytter, Paul M. Lantos, Valery Lavergne, H. Cody Meissner, Mikala C. Osani, Jane Glazer Rips, Sunil K. Sood, Edouard Vannier, Elizaveta E. Vaysbrot, Gary P. Wormser
Summary: This guideline provides evidence-based guidance for the diagnosis and management of babesiosis, with recommendations for co-infection with Lyme disease to be addressed separately. The target audience includes primary care physicians and specialists in various fields.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Nicholas A. Frisco, Alexander H. Gunn, Frances Wang, Michael T. Stang, Hadiza S. Kazaure, Randall P. Scheri
Summary: This study aimed to explore nationwide practice patterns for managing medullary thyroid cancer (MTC) in relation to the 2015 American Thyroid Association guidelines and their impact on patient survival. The study found that the rate of guideline-concordant surgery increased over time and was associated with longer overall survival and disease-specific survival. The use of chemotherapy among patients with distant disease has gradually increased, but prognosis remains variable.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Oncology
Matti Aapro, Florian Scotte, Yolanda Escobar, Luigi Celio, Richard Berman, Alessandra Franceschetti, Danielle Bell, Karin Jordan
Summary: This study reveals low adherence to antiemetic guidelines in highly emetogenic chemotherapy setting in daily clinical practice across five European countries, with only 15% of patients receiving guideline-recommended NK(1)RA-5-HT(3)RA-dexamethasone prophylaxis and 12% receiving no antiemetics. Strategies to improve adherence to guidelines are urgently needed.
Article
Critical Care Medicine
Peter J. Mazzone, Gerard A. Silvestri, Lesley H. Souter, Tanner J. Caverly, Jeffrey P. Kanne, Hormuzd A. Katki, Renda Soylemez Wiener, Frank C. Detterbeck
Summary: Evidence suggests that low-dose CT screening for lung cancer can result in a favorable balance of benefit and harms. Factors such as the selection of screen-eligible individuals, the quality of imaging and image interpretation, the management of screen-detected findings, and the effectiveness of smoking cessation interventions can impact this balance.
Article
Otorhinolaryngology
Amanda Del Risco, Alex Cherches, Sherri L. Smith, Kristal M. Riska
Summary: This study retrospectively reviewed the charts of 458 patients diagnosed with benign paroxysmal positional vertigo (BPPV) in primary care. It found gaps in adherence to the 2017 AAO-HNS guidelines for the management and treatment of BPPV. However, these gaps did not differ by sex, race, or insurance status.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Magnolia Cardona, Louise Craig, Mark Jones, Oyungerel Byambasuren, Mila Obucina, Laetitia Hattingh, Justin Clark, Paul Glasziou, Tammy Hoffmann
Summary: This review investigates the extent of overuse and underuse of antithrombotic treatment for primary or secondary prevention. The findings reveal wide practice variations in hospitals and primary care, and identify clinician and patient-driven factors contributing to non-adherence to guidelines.
Article
Critical Care Medicine
Peter J. Mazzone, Gerard A. Silvestri, Lesley H. Souter, Tanner J. Caverly, Jeffrey P. Kanne, Hormuzd A. Katki, Renda Soylemez Wiener, Frank C. Detterbeck
Summary: Low-dose chest CT screening for lung cancer has shown a favorable balance of benefit and harms, but factors such as the selection of screen-eligible individuals, imaging quality and interpretation, management of screen-detected findings, and effectiveness of smoking cessation interventions can impact this balance.
Article
Computer Science, Interdisciplinary Applications
Gregor Lichtner, Brian S. Alper, Carlo Jurth, Claudia Spies, Martin Boeker, Joerg J. Meerpohl, Falk von Dincklage
Summary: This study proposes a FHIR-based format that uses computer-interpretable representations of knowledge artifacts to directly generate evidence-based recommendations. An information model and corresponding representation based on FHIR resources were developed, allowing for the transparent evaluation of evidence and the facilitation of computer-interpretable guideline recommendations.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Nursing
Deneke Gebre, Rajalakshmi Murugan, Ketema Bizuwork, Teshome Habte Wurjine
Summary: This study assessed the knowledge, practice, and perceived barriers towards chemotherapy-induced nausea and vomiting prophylaxis guideline adherence among nurses in oncology units in Ethiopia. The results indicated that nurses had poor practice and limited knowledge of the guidelines, highlighting the need for training and encouraging the use of standard guidelines.
Article
Critical Care Medicine
Harrison B. Smith, Ralph Ward, Cassie Frazier, Jonathan Angotti, Nichole T. Tanner
Summary: This study compared the feasibility of centralized and decentralized approaches in lung cancer screening and found that the centralized approach had higher annual adherence and eligibility rates for patients.
Article
Psychology, Developmental
Kristina Muecke, Julia Plueck, Susanne Steinhauser, Martin Hellmich, Kristin Scholz, Astrid Sonneck, Lisa Winkler, Manfred Doepfner
Summary: This study evaluated guideline adherence for the assessment and treatment of children and adolescents with ADHD in German routine care. The results showed that most rates of guideline adherence for ADHD patients were in the moderate range, with only small differences between professional groups. There is a need for further strategies to monitor the quality of ADHD routine care in Germany.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Oncology
Alina Krause, Gertraud Stocker, Ines Gockel, Daniel Seehofer, Albrecht Hoffmeister, Hendrik Blaeker, Timm Denecke, Regine Kluge, Florian Lordick, Maren Knoedler
Summary: This study analyzed the adherence of recommendations from multicenter tumor board meetings for gastrointestinal cancers to national guidelines and their implementation in clinical practice. The findings showed that 76% of the meetings fully adhered to the guidelines, with 16% showing deviations primarily due to study inclusions and patient comorbidities. In 8% of case discussions, guideline adherence could not be determined due to the absence of specific recommendations. The study also revealed that 64% of all cases fully implemented the tumor board's treatment recommendations, while 21% showed deviations mainly due to comorbidities and differing patient wishes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
A. Youssef, E. E. L. O. Lashley, N. Vermeulen, M. L. P. van der Hoorn
Summary: A nationwide survey in the Netherlands revealed discrepancies between recurrent pregnancy loss (RPL) guidelines and actual practice. These discrepancies can be considered in developing a new guideline and implementing strategies to improve the quality of care provided to RPL patients, reducing the need for cross border reproductive care.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Lori C. Sakoda, M. Patricia Rivera, Jie Zhang, Pasangi Perera, Cecile A. Laurent, Danielle Durham, Roger Huamani Velasquez, Lindsay Lane, Adam Schwartz, Charles P. Quesenberry, George Minowada, Louise M. Henderson
Summary: This study evaluates patterns and factors associated with adherence to annual screening for lung cancer after negative results of a baseline examination, particularly in centralized vs decentralized screening programs. Adherence was suboptimal overall, but higher among individuals screened through centralized programs. Age was also a significant factor associated with adherence. Further efforts to improve adherence are needed to realize the benefits of lung cancer screening.
Article
Genetics & Heredity
Katerina S. Kucera, Beth Lincoln Boyea, Brooke Migliore, Sarah Nelson Potter, Veronica R. Robles, Oksana Kutsa, Heidi Cope, Katherine C. Okoniewski, Anne Wheeler, Catherine W. Rehder, Edward C. Smith, Holly L. Peay
Summary: Screening for elevated CK-MM levels in dried blood spots is a feasible method to identify newborns with DMD. Including specific cutoffs, repeat testing, and genetic sequencing can improve the accuracy and sensitivity of screening.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Madeline Currey, Ilana Solomon, Sarah Mcgraw, Jenny Shen, Francisco Munoz, Ernesto Sosa, Vanessa Puello-Lozano, Sam Wing, Lisa Lopez, Michelle Afkhami, Janine Lobello, Szabolcs Szelinger, Stacy W. Gray
Summary: This study conducted qualitative interviews with cancer patients and providers to identify gaps in clinical care and propose care delivery solutions for the return of secondary germline findings. The responses of patients varied depending on the amount of pre-test counseling they received, and providers identified insufficient clinic time as a major barrier to pretest education. Online support tools and standardized pre-test education models were favored by providers. There were differing perspectives on how pre-test education should be integrated into clinical workflows, but agreement on the inclusion of differences between somatic and germline testing, likelihood of medically actionable findings, and the possibility of being referred to a genetics provider.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Kiely N. James, Shimul Chowdhury, Yan Ding, Sergey Batalov, Kelly Watkins, Yong Hyun Kwon, Lucitia Van Der Kraan, Katarzyna Ellsworth, Stephen F. Kingsmore, Lucia Guidugli
Summary: This study used genome sequencing to detect a wide range of copy-number variants (CNVs) and other non-single nucleotide variant/indel variant types. These genetic alterations accounted for 15.8% of reported variants, with deletions being the most common type. The study also found that additional genetic tests were ordered in some cases, but failed to report the variants detected by genome sequencing.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Asem Berkalieva, Nicole R. Kelly, Ashley Fisher, Samuel F. Hohmann, Monisha Sebastin, Miranda Di Biase, Katherine E. Bonini, Priya Marathe, Jacqueline A. Odgis, Sabrina A. Suckiel, Michelle A. Ramos, Rosamond Rhodes, Noura S. Abul-Husn, John M. Greally, Carol R. Horowitz, Melissa P. Wasserstein, Eimear E. Kenny, Bruce D. Gelb, Bart S. Ferket
Summary: The study aims to understand the effects of returning diagnostic sequencing results on clinical actions and economic outcomes for pediatric patients with suspected genetic disorders. The results showed that patients with positive findings were more likely to receive specialist consultation, but there were no significant increases in overall physician services and costs. More large-scale studies are needed to confirm these findings.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Kirstine Stochholm, Camilla Holmgard, Shanlee M. Davis, Claus H. Gravholt, Agnethe Berglund
Summary: This study assessed the incidence, prevalence, and age at diagnosis of individuals with 45,X/46,XY mosaicism and described the associated mortality pattern. The study found an increasing incidence of 45,X/46,XY mosaicism in males and a stable incidence in females. Males were diagnosed at an older age than females. Additionally, 45,X/46,XY mosaicism was associated with increased all-cause mortality.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Yunjia Chen, Ender Karaca, Nathaniel H. Robin, Dana Goodloe, Ali Al-Beshri, S. Joy Dean, Anna C. E. Hurst, Andrew J. Carroll, Fady M. Mikhail
Summary: This study confirms the association between DLG2 intragenic deletions and neurodevelopmental disorders, supports the haploinsufficiency of the DLG2 gene, and suggests a potential association between these deletions and congenital anomalies and dysmorphism.
GENETICS IN MEDICINE
(2024)