Article
Environmental Sciences
M. Alaguprathana, M. Poonkothai, Mysoon M. Al-Ansari, Latifah Al-Humaid, Woong Kim
Summary: This study assessed the cytogenotoxic effect of untreated and methyl orange treated on Allium cepa roots. It was found that roots exposed to treated dye solution had higher root growth, root length, and mitotic index, while roots exposed to untreated dye solution showed higher mitotic inhibition and chromosomal abnormalities. The research can be used as a biomarker to detect the genotoxic effects of textile dyes on biota.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Eslem Amac, Recep Liman
Summary: This study evaluated the dose-dependent cytotoxicity and genotoxicity of clopyralid on Allium cepa roots, showing that clopyralid affects root growth and induces chromosome abnormalities at different concentrations. These results confirm the cytotoxic and genotoxic effects of clopyralid on non-target organisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Agronomy
Cornelia Purcarea, Vasile Laslo, Adriana Ramona Memete, Eliza Agud, Florina Miere (Groza), Simona Ioana Vicas
Summary: This study demonstrates the potential of proline as an osmoprotectant to alleviate the genotoxic effects caused by cadmium exposure in plants. The results show that the application of proline before or after cadmium treatment reduces DNA damage and chromosomal aberrations.
Article
Food Science & Technology
Antonio Cascajosa-Lira, Maria Puerto, Ana I. Prieto, Silvia Pichardo, Leticia Diez-Quijada Jimenez, Alberto Banos, Enrique Guillamon, Rosario Moyano, Veronica Molina-Hernandez, Angeles Jos, Ana M. Camean
Summary: This study confirmed the lack of in vivo genotoxicity of PTS at the doses tested, indicating that it is a promising natural alternative in animal feed without adverse effects on genetic material.
Article
Environmental Sciences
Anithadevi Kenday Sivaram, Panneerselvan Logeshwaran, Aravind Surapaneni, Kalpit Shah, Nicholas Crosbie, Zoe Rogers, Elliot Lee, Kartik Venkatraman, Kurunthachalam Kannan, Ravi Naidu, Mallavarapu Megharaj
Summary: The study found that PFOS has significant cytotoxic and genotoxic effects on Allium cepa root meristem cells. As the concentration increases, cell division decreases and chromosomal aberrations increase. This is the first study to investigate the cyto-genotoxic potential of PFOS in higher plants.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Environmental Sciences
Milda Babonaite, Matas Cepulis, Jurate Kazlauskaite, Juozas Rimantas Lazutka
Summary: According to PlasticEurope, global plastics production reached 390.7 million tons in 2021. Unfortunately, a large portion of these plastics end up as waste in the ocean or on land due to their non-biodegradable nature. This study focused on evaluating the internalization rates, cytotoxicity, and genotoxicity of polystyrene nanoparticles (PS-NPs) in human peripheral blood mononuclear cells (PBMCs) in vitro. The results showed that while PS-NPs did not have a cytotoxic effect on PBMCs, they did induce primary DNA damage and micronucleated cells, indicating their genotoxic potential.
Article
Environmental Sciences
Uthpala A. Jayawardena, Deepthi D. Wickramasinghe, Preethi Udagama
Summary: This study evaluated the cytogenotoxicity of heavy metal contamination in a polluted urban wetland using a battery of cytogenotoxic assays. Different exposure conditions led to varying genotoxic effects of the heavy metal mixture on frog erythrocytes, with the Allium cepa bioassay showing lower sensitivity to heavy metals.
Article
Environmental Sciences
Raphael B. de Souza, Cleiton Pereira de Souza, Jose Roberto Guimaraes
Summary: This study evaluated the phytotoxicity and genotoxicity of Eprinomectin, a veterinary drug widely used in the agricultural sector. The results showed that Eprinomectin affected root development and germination speed, as well as induced chromosomal aberrations and micronuclei. Therefore, the release of Eprinomectin into the environment should be minimized.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Wei Liu, Zechang Li, Xiaoyu Cui, Fang Luo, Chunyan Zhou, Jiangyu Zhang, Liguo Xing
Summary: The genotoxicity of nitenpyram (NIT) has been evaluated using human bone marrow mesenchymal stem cells (hBMSCs), showing potential genotoxic effects through oxidative stress and dysregulation of various signaling pathways. Although the risk of NIT alone to human health is low, the synergistic or additive effects with other pesticides should be considered.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Plant Sciences
Debora Elisa Antunes de Mendonca, Mariane Aparecida Franco de Godoy, Naiara Cristina Lucredi, Jurandir Fernando Comar, Igor Vivian Almeida, Veronica Elisa Pimenta Vicentini
Summary: This study evaluated the effects of Ganoderma lucidum fruiting body dry extract (GLE) on human liver and kidney tumor cells as well as peripheral blood lymphocytes. The results showed that low concentrations of GLE increased lymphocyte viability while high concentrations were toxic to lymphocytes. On the other hand, low concentrations of GLE exhibited cytotoxic activity and induced DNA damage in tumor cells. Therefore, G. lucidum has potential antitumor effects and could be developed into a therapeutic agent for cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Priyanka Prajapati, Praveen Gupta, Ravindra Nath Kharwar, Chandra Shekhar Seth
Summary: This study investigates the response of Allium cepa L. roots to salt stress and explores the effects of NO supplementation on chromosomal aberrations and biochemical responses. The results suggest that NO supplementation can improve the functioning of A. cepa L. roots and alleviate salt-induced chromosomal aberrations and DNA damage.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2023)
Article
Pharmacology & Pharmacy
Raffaella di Vito, Mattia Acito, Cristina Fatigoni, Carl H. Schiesser, Michael J. Davies, Francesca Mangiavacchi, Milena Villarini, Claudio Santi, Massimo Moretti
Summary: This study evaluated the cytotoxic and genotoxic potential of SeTal in liver cells through in vitro experiments. The results showed that SeTal had minimal impact on cell viability and did not cause clastogenic or aneugenic activity. These findings suggest that SeTal may be a potential active pharmaceutical ingredient.
Article
Toxicology
Pegah Jalili, Sylvie Huet, Agnes Burel, Benjamin-Christoph Krause, Caroline Fontana, Soizic Chevance, Fabienne Gauffre, Yves Guichard, Alfonso Lampen, Peter Laux, Andreas Luch, Kevin Hogeveen, Valerie Fessard
Summary: This study investigated the in vitro genotoxic potential of Al2O3 and Al-0 NMs in intestinal and liver cell models, compared with the ionic form AlCl3. While all forms of aluminum did not induce chromosomal damage, Al2O3 NMs caused oxidative DNA damage in Caco-2 cells and Al-0 NMs induced DNA damage in both cell lines. However, no genotoxic effects were observed with AlCl3. Additionally, no cytotoxicity, apoptosis, gamma H2AX or cell transformation were induced by any form of aluminum compounds in this study.
TOXICOLOGY IN VITRO
(2022)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Daiany Folador Sotero, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Rinneu Elias Borges, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Pollution from mining activities can cause genotoxic damage to bats, particularly in species like Carollia perspicillata and Glossophaga soricina. High levels of elements such as Mn, Cr, Pb, and Zn were found in water samples from the mining area. The study suggests that bats in mining areas are susceptible to increased DNA damage, similar to what has been observed in other species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Peter Moller, Regitze Solling Wils, Emilio Di Ianni, Claudia Andrea Torero Gutierrez, Martin Roursgaard, Nicklas Raun Jacobsen
Summary: The review summarizes the genotoxic effects of JRC materials and MWCNT-7, with a significant increase in the current database compared to the IARC monograph. Cell culture studies show a genotoxic response by MWCNT-7, less consistent effect by NM-400 and NM-402, and least consistent effect by NM-401 and NM-403, indicating strongest evidence of genotoxicity for MWCNT-7. There are limited observations from animal models and humans to draw general conclusions about genotoxicity.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Oncology
Raquely M. Lenzi, Luciano H. Campestrini, Simone C. Semprebon, Jonas A. R. Paschoal, Monique A. G. Silva, Selma F. Zawadzki-Baggio, Mario S. Mantovani, Carmen L. O. Petkowicz, Juliana B. B. Maurer
Summary: Consumption of GL-rich foods like Brassica vegetables and maca is linked to reduced cancer risk. Maca has significantly higher GL content and shows growth-inhibitory effects against cancer cell lines, supporting its categorization as a superfood.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Rafael Claudino dos Santos, Raquel Oliveira Nascimento de Freitas, Mary Ann Foglio, Joao Ernesto de Carvalho, Ana Lucia Tasca Goes Ruiz, Lucas Roberto Pessatto, Rodrigo Juliano Oliveira, Adrivanio Baranoski, Bruna Isabela Biazi, Mario Sergio Mantovani, Candida Aparecida Leite Kassuya, Pedro Cruz de Oliveira Junior, Anelise Samara Nazari Formagio
Summary: This study synthesized and evaluated a series of galloyl-substituted compounds for their antiproliferative activity. The results showed that some of these compounds exhibited moderate to high inhibition activity against various human cancer cells, and galloyl hydrazide also demonstrated cytotoxicity in hepatocarcinoma cells.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Toxicology
Andressa Megumi Niwa, Simone Cristine Semprebon, Glaucia Fernanda Rocha D'Epiro, Lilian Areal Marques, Thalita Alves Zanetti, Mario Sergio Mantovani
Summary: The study demonstrates that salinomycin has antitumor potential against human hepatocellular carcinoma cells through inducing cell cycle arrest, upregulating certain genes related to apoptosis, and modulating hepatic cytochrome P450 expression. These findings suggest that salinomycin may interfere with chemotherapy treatment by affecting metabolizing enzymes and should be considered in conjunction with other treatments.
TOXICOLOGY MECHANISMS AND METHODS
(2022)
Article
Environmental Sciences
Luan Vitor Alves de Lima, Matheus Felipe da Silva, Virginia Marcia Concato, Debora Berbel Lirio Rondina, Thalita Alves Zanetti, Ingrid Felicidade, Lilian Areal Marques, Sandra Regina Lepri, Ane Stefano Simionato, Galdino Andrade Filho, Giuliana Castello Coatti, Mario Sergio Mantovani
Summary: Fluopsin C, an antibiotic compound derived from microorganisms, has exhibited antitumor, antibacterial, and antifungal activities. This study investigated the mechanisms of fluopsin C's antiproliferative effects, including cytotoxicity, genotoxicity, cell cycle arrest, apoptosis induction, mitochondrial membrane potential change, and modulation of mRNA expression of genes involved in stress response and cell death. The results demonstrated that fluopsin C interferes with tumor spheroid growth and regulates essential molecular processes associated with stress and cell death.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Biotechnology & Applied Microbiology
Matheus Felipe da Silva, Luan Vitor Alves de Lima, Thalita Alves Zanetti, Ingrid Felicidade, Phelipe Oliveira Favaron, Sandra Regina Lepri, Debora Berbel Lirio Rondina, Mario Sergio Mantovani
Summary: This study aimed to evaluate the mechanisms of action of diosgenin in human hepatocellular carcinoma cells. The results showed that diosgenin induced cell cycle arrest and apoptosis through DNA damage, leading to reduced cell viability and inhibited growth of spheroids.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Endocrinology & Metabolism
Marilia Rizzon Zaparolli Ramos, Ingrid Felicidade, Ligia de Oliveira Carlos, Nathalia Ramori Farinha Wagner, Mario Sergio Mantovani, Luan Vitor Alves de Lima, Lucia Regina Ribeiro, Thiago Inacio Barros Lopes, Fernanda Carla Henrique-Bana, Joao Vitor Zimmerman, Fernando Cesar Macedo Junior, Magda Rosa Ramos da Cruz, Antonio Carlos Ligocki Campos
Summary: This study investigated the effects of probiotic supplementation on the plasma metabolite profile after Roux-Y gastric bypass (RYGB). The results showed that probiotics were associated with significant differences in plasma metabolites, contributing to improved metabolic health.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Mycology
Cassia Milena de Souza, Alane Tatiana Pereira Moralez, Murilo Moreira dos Santos, Mario Sergio Mantovani, Luciana Furlaneto-Maia, Marcia Cristina Furlaneto
Summary: The structure and genetic factors of switched morphotypes colonies in Candida tropicalis were investigated. The switched colonies had distinct arrangements of ECM, higher amounts of total carbohydrates and proteins in ECM, and higher percentage of hyphae. The expression levels of EFG1, WOR1, and BCR1 were significantly higher in the switched colonies.
Article
Pharmacology & Pharmacy
Lilian Areal Marques, Simone Cristine Semprebon, Bruna Isabela Biazi, Ingrid Felicidade, Thalita Alves Zanetti, Adrivanio Baranoski, Virginia Marcia Concato, Wander Rogerio Pavanelli, Mario Sergio Mantovani
Summary: This study demonstrates the synergistic cytotoxic and antiproliferative effects of Salinomycin and 1,25D on MCF-7 breast carcinoma cells. The combination of these two drugs activates multiple cell death pathways and inhibits cell proliferation, suggesting a potential novel therapy strategy for breast cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Toxicology
Camila Lehnhardt Pires, Thalita Alves Zanetti, Mario Sergio Mantovani, Isabel O'Neill de Mascarenhas Gaivao, Fabio Ferreira Perazzo, Paulo Cesar Pires Rosa, Edson Luis Maistro
Summary: This study investigated the effects of Pracaxi oil on HepG2/C3A cells and found that the oil did not have significant cytotoxic, cell cycle, or apoptosis effects. Additionally, the oil up-regulated genes related to metabolism, cell proliferation, and oxidative stress.
TOXICOLOGY IN VITRO
(2022)
Article
Toxicology
Ana Paula Oliveira De Quadros, Bruna Oshiiwa, Marcel Petreanu, Rivaldo Niero, Paulo Cesar Pires Rosa, Alexandra Christine Helena Frankland Sawaya, Mario Sergio Mantovani, Isabel O'Neill De Mascarenhas Gaivao, Edson Luis Maistro
Summary: Rubus rosifolius, a common medicinal plant in southern Brazil, has been found to have genotoxic and apoptotic effects in in vitro studies, indicating potential risks in human use.
TOXICOLOGY IN VITRO
(2023)
Article
Toxicology
Debora Berbel Lirio Rondina, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Thalita Alves Zanetti, Ingrid Felicidade, Lilian Areal Marques, Giuliana Castello Coatti, Mario Sergio Mantovani
Summary: This study evaluated the cytotoxicity of ZER combined with chemotherapeutic agents and its effect on the expression of mRNA genes related to cell cycle, cell death, xenobiotic metabolism, DNA damage, and endoplasmic reticulum stress. The results showed that ZER had cytotoxic and antiproliferative effects, and could modulate the expression of genes involved in various cellular processes. However, its efficacy might be influenced when combined with other chemotherapeutic agents.
TOXICOLOGY IN VITRO
(2022)
Article
Environmental Sciences
Ana Paula Oliveira de Quadros, Isabel Braganca Baraldi, Marcel Petreanu, Rivaldo Niero, Mario Sergio Mantovani, Isabel O'Neill De Mascarenhas Gaivao, Edson Luis Maistro
Summary: Extracts from the leaves and stems of Rubus rosifolius may have adverse effects on humans, causing genotoxic and mutagenic effects on DNA in cells.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Environmental Sciences
Liana Martins de Oliveira, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Ingrid Felicidade, Sandra Regina Lepri, Mario Sergio Mantovani
Summary: Curcumin, extracted from Curcuma longa L, has been studied for its antiproliferative activity using different cell culture systems. This study investigated the effects of curcumin on cytotoxicity, genotoxicity, and spheroid growth, and found that curcumin exhibited potential for drug development with antiproliferative activity in cancer.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Pharmacology & Pharmacy
Nayane de Oliveira Silva, Luan Vitor Alves de Lima, Liana Martins de Oliveira, Matheus Felipe da Silva, Amanda Passuello de Aguiar, Simone Cristine Semprebon, Phelipe Oliveira Favaron, Sandra Regina Lepri, Ingrid Felicidade, Mario Sergio Mantovani
Summary: This study evaluated the antiproliferative effects of ZER on HT-29 cells, and found that ZER could inhibit cell migration, induce apoptosis and cell cycle arrest, and affect key signaling pathways.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Gerontology
Liliya Martynova
Summary: Since the 1960s, the goal of active longevity has been repeatedly mentioned in Russian policy documents. Two interpretations of the term exist, with one considering it synonymous with active aging and the other viewing it as a policy goal alongside other aspects of healthy aging, employment, and social participation. Current observations on active longevity policy implementations show progress in health-care development and social participation, but pose challenges in terms of employment and life expectancy data.
JOURNAL OF AGING & SOCIAL POLICY
(2023)