4.4 Article

Sex-Specific Effects of Cis-Regulatory Variants in Drosophila melanogaster

Journal

GENETICS
Volume 195, Issue 4, Pages 1419-+

Publisher

GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.113.156331

Keywords

gene regulation; trans-regulation; epistasis; imprinting; allele-specific expression

Funding

  1. National Institutes of Health [5F32GM089009-02]
  2. National Science Foundation [MCB-1021398, 1038099]
  3. Alfred P. Sloan Research Foundation
  4. Direct For Biological Sciences [1021398] Funding Source: National Science Foundation
  5. Direct For Education and Human Resources [1038099] Funding Source: National Science Foundation
  6. Division Of Human Resource Development [1038099] Funding Source: National Science Foundation
  7. Div Of Molecular and Cellular Bioscience [1021398] Funding Source: National Science Foundation

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Sexual dimorphism at the level of gene expression is common and well documented, but much less is known about how different cis-regulatory alleles interact with the different trans-regulatory environments present in males and females. Here we show that sex-specific effects of cis-regulatory variants are common in Drosophila.

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