Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Yi Zhong, Li Deng, Jiafu Li, Xiaoqiu Tan, Jian Feng
Summary: Diabetes eventually leads to chronic vascular complications, with TGR5 potentially serving as a novel therapeutic target for diabetes-associated endothelial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ulises Novoa, Karen Soto, Cristian Valdes, Jorge Villasenor, Adriana Treuer, Daniel R. Gonzalez
Summary: This study found that treatment with BH4 can prevent the development of diabetic cardiomyopathy and nephropathy. BH4 treatment reduced cardiac hypertrophy and fibrosis, as well as glomerular hypertrophy and fibrosis. These results suggest that BH4-based treatment may ameliorate the cardiorenal effects of diabetes by restoring the nitroso-redox balance.
Article
Chemistry, Multidisciplinary
Tian-tian Liu, Huan-huan Xu, Ze-juan Liu, He-ping Zhang, Hai-tao Zhou, Zhi-xiang Zhu, Zhi-qiang Wang, Jing-yi Xue, Qiang Li, Yi Ma, Hong-jie You, Da-li Luo
Summary: Endothelial dysfunction is a central characteristic of cardiovascular pathogenesis in diabetes mellitus, characterized by impaired eNOS and NO bioavailability. This study identified the role of CaM in the dysfunction of eNOS in diabetes. Downregulated CaM expression was found to be responsible for endothelial injury and impaired angiogenesis in diabetes. The findings provide a novel mechanism and target for protecting against diabetic endothelial injury.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
S. S. HABIB, K. A. AL-REGAIEY, T. AL-KHLAIWI, S. M. HABIB, S. BASHIR, F. AL-HUSSAIN, S. H. HABIB
Summary: This study found that T2DM patients have higher levels of serum iNOS and lower levels of eNOS. In T2DM patients with concomitant CAD, iNOS levels were significantly higher. Additionally, iNOS activity correlated positively with glycemic control and hsCRP.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Damian Gajecki, Jakub Gawrys, Jerzy Wisniewski, Paulina Fortuna, Ewa Szahidewicz-Krupska, Adrian Doroszko
Summary: The study reveals significant differences in the nitric oxide metabolic pathway in patients with type 2 diabetes, particularly in the plasma compartment. Erythrocytes serve as a buffer with higher nitric oxide bioavailability, less affected by diabetes-related deviations. Individuals with type 2 diabetes show endothelial dysfunction.
Review
Medicine, General & Internal
Yushan Shi, Xin Fan, Kaiyun Zhang, Yaling Ma
Summary: This study conducted a systematic review and meta-analysis on the association between eNOS 4a/b polymorphism and the risk of developing DR in T2DM patients. The results showed that eNOS 4a/b intron 4a allele is a risk factor for DR in Caucasians, suggesting its potential as a biomarker for early screening and diagnosis of DR in Caucasian T2DM patients.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yanyan Jiang, Jianhua Li, Juan Zhang, Sufang Chen
Summary: This study found a strong correlation between serum VEGF and glycemic control and diabetic nephropathy severity in Chinese older adults with type 2 diabetes mellitus. Both males and females with DN had higher VEGF levels than non-DN, and VEGF showed a positive correlation with UACR and HbA1c. Serum VEGF could be considered as a predictive biomarker for glycemic control and diabetic nephropathy in older adults with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Andrology
Li Liu, Xiao Wang, Kang Liu, Jiaqi Kang, Shangren Wang, Yuxuan Song, Kechong Zhou, Lu Yi, Xiaoqiang Liu
Summary: This study investigated the role of iNOS in diabetes mellitus erectile dysfunction (DMED) and confirmed that upregulation of iNOS leads to microvascular dysfunction in patients with ED. Inhibiting iNOS showed beneficial effects in the treatment of ED, suggesting further exploration of its mechanism is warranted.
Article
Biochemistry & Molecular Biology
Eva Ruisanchez, Anna Janovicz, Rita Cecilia Panta, Levente Kiss, Adrienn Parkanyi, Zsuzsa Straky, David Korda, Karoly Liliom, Gabor Tigyi, Zoltan Benyo
Summary: Enhanced sphingomyelinase activity in a mouse model of type 2 diabetes mellitus leads to altered vascular effects, showing marked relaxation in diabetic mice. Sphingomyelinase has dual vasoactive effects, including TP-mediated vasoconstriction and NO-mediated vasorelaxation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Review
Biochemistry & Molecular Biology
Subir Kumar Juin, Rosemary Ouseph, Dibson Dibe Gondim, Venkatakrishna Rao Jala, Utpal Sen
Summary: Diabetic nephropathy (DN) is still the main cause of morbidity and mortality in diabetes patients. Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), play a vital role in the development and progression of DN. Aberrant levels of gasotransmitters have been observed in patients with diabetes, and gasotransmitter donors show potential in ameliorating diabetic renal dysfunction. This review provides an overview of the physiological relevance of gasotransmitters and their interaction with other factors in the severity modulation of DN, highlighting the possible therapeutic interventions.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Immunology
Mohammed M. Abuelmagd, A. M. Nagib, Megahed M. Abuelmagd, A. F. Refaie, Y. A. Elhindi, M. F. Ahmed, M. H. Ali, H. M. Elmaghrabi, M. A. Bakr
TRANSPLANTATION PROCEEDINGS
(2015)
Article
Urology & Nephrology
Mohamed Fouad, Ibrahim Salem, Khaled Elhefnawy, Nermin Raafat, Amal Faisal
INDIAN JOURNAL OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Mohamed Fouad, Maher Boraie
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2016)
Article
Urology & Nephrology
Mohamed Fouad, Maher Boraie
TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
(2015)
Article
Urology & Nephrology
Amany Ibrahim, Tarik Zaher, Tarek A. Ghonemy, Shymaa Abd El-Azim, Marwa Abd El-Azim, Ayman Ramadan
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2010)