Article
Oncology
Ibrahim O. Alanazi, Jilani Purusottapatnam Shaik, Narasimha Reddy Parine, Abdulrahman Al Naeem, Nahla A. Azzam, Majid A. Almadi, Abdulrahman M. Aljebreen, Othman Alharbi, Mohammad Saud Alanazi, Zahid Khan
Summary: Breast cancer and colorectal cancer are common malignancies with various genetic alterations in signaling pathway genes. Specific single nucleotide polymorphisms in NOTCH genes were found to be associated with susceptibility to these cancers in the Saudi population. Further validation in larger populations of different ethnicities could potentially identify these SNPs as genetic screening markers for early detection of breast and colorectal carcinomas.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Medicine, General & Internal
Maha Daghestani, Nashwa Othman, Mohammed A. Omair, Fahidah Alenzi, Maha A. Omair, Eman Alqurtas, Shireen Amin, Arjumand Warsy
Summary: This study conducted an investigation on the Saudi population and found that 6 single nucleotide polymorphisms (SNPs) were significantly associated with rheumatoid arthritis (RA), with 4 of them having a protective effect. Two SNPs showed significantly higher heterozygote frequencies in the control group compared to the patients. This indicates considerable heterogeneity in the genetics of RA in different populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Weihong Xiong, Zhumei Li, Xiangfa Zeng, Jun Cui, Zhiming Cheng, Xiaoying Yang, Yipeng Ding
Summary: This study found that ANXA6 gene variants are associated with susceptibility to head and neck cancer in the Chinese Han population, suggesting that ANXA6 may serve as a potential biomarker for prognosis and diagnosis of head and neck cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ilda Hoxhaj, Vladimir Vukovic, Stefania Boccia, Roberta Pastorino
Summary: Through systematic review and meta-analysis, we identified certain SNPs that may serve as potential markers for identifying HNC survivors at high risk of developing SPC.
Review
Cell Biology
Farbod Bahreini, Elham Rayzan, Nima Rezaei
Summary: Breast cancer, a multifactorial disease, may have an increased risk due to alterations in microRNA sequences. miR-SNPs are potential biomarkers for early detection of breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Biochemistry & Molecular Biology
Thiago Celestino Chulam, Fernanda Bernardi Bertonha, Rolando Andre Rios Villacis, Joao Goncalves Filho, Luiz Paulo Kowalski, Silvia Regina Rogatto
Summary: This study examines the role of inherited cancer predisposition genes in head and neck cancer families. The results show that multiple first-degree relatives in these families have head and neck cancer or other related tumors, indicating the importance of genetics in cancer development.
Review
Oncology
Antra, Palak Parashar, Hungharla Hungyo, Anuja Jain, Shandar Ahmad, Vibha Tandon
Summary: Head and neck squamous cell carcinomas (HNSCC) pose major challenges in treatment due to their heterogeneity, late-stage diagnosis, and high recurrence rate. Current biomarkers for diagnosis and prognosis of HNSCC mainly rely on smoking as the major risk factor. This review focuses on the differential environment and gene mutations of HNSCC in Indian patients who consume smokeless tobacco. It reveals frequent mutations in genes involved in DNA repair, cell proliferation, cell death, metastasis, lymphocyte proliferation, cell-cell adhesion, miRNA processing, and inflammatory responses in Indian HNSCC patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Biology
Mahmood Rasool, Peter Natesan Pushparaj, Abdelbaset Buhmeida, Sajjad Karim
Summary: Colorectal cancer is a leading cause of death in males in Saudi Arabia and is also among the top five cancer types in females. A study on BRAF mutations in 100 Saudi CRC patients revealed six mutations, with four being reported for the first time. These findings provide insights into the molecular etiology of CRC.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Amerh S. Alqahtani, Raniah S. Alotibi, Taghrid Aloraini, Fahad Almsned, Yara Alassali, Ahmed Alfares, Bader Alhaddad, Mariam M. Al Eissa
Summary: Rare diseases in Saudi Arabia create a significant burden for both the government and families due to the long-term treatment or rehabilitation required. This study aims to investigate the genetic component of the prevalence of rare diseases in Saudi Arabia.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Environmental Sciences
Abdelhabib Semlali, Mikhlid H. Almutairi, Sultan N. Alharbi, Abdullah M. Alamri, Abdulwahed F. Alrefaei, Bader O. Almutairi, Mahmoud Rouabhia
Summary: The study found a significant correlation between SNPs in the TSLPR genes and breast cancer progression among women in Saudi Arabia. The T allele of the P196L SNP was found to have a protective effect against breast cancer progression in participants younger than 48 years old, while the CT and TT genotypes were associated with breast cancer risk protection in participants older than 48 years old.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Bengt-Ake Andersson, Mats Nilsson, Delmy Oliva
Summary: This study analyzed the effects of SNPs associated with smoking and HPV on the risk and survival of HNSCC patients. The results showed differences in SNP genotypes between smokers and non-smokers, indicating a possible interaction between genetics and smoking in the pathogenesis of HNSCC.
Article
Multidisciplinary Sciences
Ji-Hye Choi, Bok-Soon Lee, Jeon Yeob Jang, Yun Sang Lee, Hyo Jeong Kim, Jin Roh, Yoo Seob Shin, Hyun Goo Woo, Chul-Ho Kim
Summary: This study profiles the molecular mechanisms behind the stepwise progression of HNSCC through single-cell RNA-seq analysis. It reveals the role of interactions with the tumor microenvironment in the progression of HNSCC.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Sitwat Zehra, Maham Ghouri, Halima Jafari, Saima Saleem, Sehrish Fatima, Abid Azhar
Summary: This study found that SNPs rs3736228 and rs4988321 are significantly associated with increased susceptibility to RA. The study provides baseline data on targeted SNPs and their association with disease progression. The findings may be utilized for the development of potential diagnostic biomarkers and precision medicine approaches.
Review
Medicine, Research & Experimental
Krishna N. Mishra, Belal A. Moftah, Ghazi A. Alsbeih
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Retraction
Oncology
Ghazi Alsbeih, Medhat El-Sebaie, Najla Al-Harbi, Khaled Al-Hadyan, Mohamed Shoukri, Nasser Al-Rajhi
RADIATION ONCOLOGY
(2018)
Article
Genetics & Heredity
Joanna Zyla, Sylwia Kabacik, Grainne O'Brien, Salma Wakil, Najla Al-Harbi, Jaakko Kaprio, Christophe Badie, Joanna Polanska, Ghazi Alsbeih
FUNCTIONAL & INTEGRATIVE GENOMICS
(2019)
Article
Oncology
Ghazi Alsbeih, Najla Al-Harbi, Sara Bin Judia, Wejdan Al-Qahtani, Hatim Khoja, Medhat El-Sebaie, Asma Tulbah
Article
Neurosciences
Anqi Yao, Sarah J. Storr, Khaled Al-hadyan, Ruman Rahman, Stuart Smith, Richard Grundy, Simon Paine, Stewart G. Martin
MOLECULAR NEUROBIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
B. Moftah, S. Aldelaijan, M. Shehadeh, F. Alzorkany, F. Alrumayan, G. Alsbeih, M. Alshabanah, J. Seuntjens, N. Tomic, S. Devic
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2020)
Article
Public, Environmental & Occupational Health
Ghazi A. Alsbeih, Khaled S. Al-Hadyan, Najla M. Al-Harbi, Sara S. Bin Judia, Belal A. Moftah
FRONTIERS IN PUBLIC HEALTH
(2020)
Article
Environmental Sciences
Khaled Al-Hadyan, Ghazi Alsbeih, Ahmad Nobah, Jeffrey Lindstrom, Sawsan Falatah, Nawarh Faran, Salem Al-Ghamdi, Belal Moftah, Rashed Alhmaid
Summary: The shortage of filtering facepiece respirators prompted healthcare institutions to reuse them while decontaminating with vapor hydrogen peroxide. A low-cost in-house filtration efficiency assessment method was developed to evaluate the effectiveness of different decontamination methods on various types of FFRs. The study found significant variations in filtration efficiency among different FFRs after repeated decontamination cycles.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Ghazi Alsbeih, Najla Al-Harbi, Sheikh Ismail, Michael Story
Summary: The study found significant differences in DNA double-strand break (DSB) repair fidelity among individuals with different radiosensitivity, with higher levels of misrepaired DSBs in radio-sensitive (RS) and ataxia-telangiectasia mutated (ATM) cells compared to normal control (NC). Misrepaired DSBs may serve as a potential marker for adverse reactions to radiotherapy, indicating the importance of DNA repair fidelity in determining individual radiosensitivity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Khaled Al-Hadyan, Ghazi Alsbeih, Najla Al-Harbi, Sara Bin Judia, Maha Al-Ghamdi, Akram Almousa, Ibtihaj Alsharif, Razan Bakheet, Khaldoun Al-Romaih, Maha Al-Mozaini, Salem Al-Ghamdi, Belal Moftah, Rashed Alhmaid
Summary: The study evaluated the effect of gamma irradiation on the filtration efficiency and SARS-CoV-2 RNA detection of FFRs. High doses of gamma irradiation can completely degrade SARS-CoV-2 RNA, but adversely affect the filtration efficiency of FFRs.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Khaled S. Al-Hadyan, Ghazi A. Alsbeih, Najla M. Al-Harbi, Sara S. Bin Judia, Maha M. Al-Ghamdi, Salem M. Al-Ghamdi, Belal A. Moftah, Rashed S. Alhmaid
Summary: The study assessed the filtration efficiency of different types of masks, showing that sealed surgical masks provide the best filtration while unsealed surgical masks, cloth masks, and face veils have comparable performance in filtering 5 μm particles, which are relevant to COVID-19. Additionally, wearing a surgical mask under a face veil significantly improves filtration efficiency.
KUWAIT JOURNAL OF SCIENCE
(2021)
Article
Oncology
Ghazi A. Alsbeih, Najla M. Al-Harbi, Sara S. Bin Judia, Hatim A. Khoja, Mohamed M. Shoukri, Asma M. Tulbah
