Article
Immunology
Yunfei Wang, Kaikai Yi, Xing Liu, Yanli Tan, Weili Jin, Yansheng Li, Junhu Zhou, Hongjun Wang, Chunsheng Kang
Summary: HOTAIR activates NF-kappa B pathway in glioma cells, promoting inflammatory signaling and immune escape.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Jing Cai, Ying Gao, Hongyan Li, Jingmin Qiao, Yiran Liu, Xue Xia, Zhikui Zheng
Summary: The study revealed that FOSL2 aggravates renal injury in diabetic nephropathy by activating the NF-kappa B signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Nicholas J. Monteleone, Carol S. Lutz
Summary: The dysregulation of TNF alpha and IL-1 beta signaling is common in autoimmune diseases and cancer, where they positively regulate AA signaling. Research has shown that miR-708 negatively regulates TNF alpha/IL-1 beta signaling in non-diseased lung cells but loses this effect in diseased lung cells. Additionally, miR-708 suppresses TNF alpha/IL-1 beta-induced changes in COX-2, mPGES-1, and PGE 2 levels, as well as TNF alpha/IL-1 beta-induced IL-6 independently of AA signaling, by reducing the expression of IKK beta.
MEDIATORS OF INFLAMMATION
(2021)
Article
Cell Biology
Mohamed Abu-Farha, Dhanya Madhu, Prashantha Hebbar, Anwar Mohammad, Arshad Channanath, Sina Kavalakatt, Nada Alam-Eldin, Fatima Alterki, Ibrahim Taher, Osama Alsmadi, Mohammad Shehab, Hossein Arefanian, Rasheed Ahmad, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker
Summary: The ANGPTL8 R59W variant is associated with increased levels of TNF alpha, IL7, and NF-kappa B p65 activity. The weak transient binding of the ANGPTL8 R59W variant explains its regulatory role on the NF-kappa B pathway and inflammation.
Review
Biochemistry & Molecular Biology
Li Tao, Xiaomeng Ren, Wenhui Zhai, Zheng Chen
Summary: The non-canonical NF-kappa B signaling pathway plays a crucial role in liver diseases by regulating liver homeostasis and participating in various pathological processes. Small-molecule inhibitors targeting this pathway have shown potential in the treatment of liver injuries.
Article
Plant Sciences
Ying Li, Jin-gang Hou, Zhi Liu, Xiao-jie Gong, Jun-nan Hu, Ying-ping Wang, Wen-cong Liu, Xiang-hui Lin, Zi Wang, Wei Li
Summary: In this study, treatment with 20(R)-Rg3 for 8 weeks in T2D mice not only decreased FBG and AGEs levels, but also improved insulin, blood lipids, oxidative stress, and renal function by regulating MAPKs and NF kappa B signal pathways, showing significant ameliorative effects on DN mice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Virology
Constanza E. Espada, Corine St Gelais, Serena Bonifati, Victoria V. Maksimova, Michael P. Cahill, Sun Hee Kim, Li Wu
Summary: SAMHD1 restricts HIV-1 replication by limiting the intracellular dNTP pool and suppresses NF-kappa B activation. This suppression is modulated by TRAF6 and TAK1, which play key roles in mediating the negative regulation of the NF-kappa B pathway by SAMHD1.
JOURNAL OF VIROLOGY
(2021)
Article
Endocrinology & Metabolism
Y. Wu, H. Deng, J. Sun, Y. Xu
Summary: This study investigated the protective effects and mechanisms of action of ISO in diabetic nephropathy. The results showed that ISO reduced glucose levels, urinary protein, serum creatinine, and blood urea nitrogen. It also suppressed fibrosis and inflammatory responses by inhibiting the activation of the TLR4/NF-kappa B signaling pathway. These findings suggest that ISO has therapeutic benefits for patients with diabetic nephropathy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Chemistry, Medicinal
Jingge Xu, Yan Wang, Zhen Wang, Lanping Guo, Xinpeng Li
Summary: The study investigated the effects of sulfated polysaccharides from Laminaria japonica on diabetic nephropathy symptoms, showing that the polysaccharides regulate diabetic nephropathy through the PKC/NF-kappa B pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Environmental Sciences
Jingyu Duan, Liangliang He, Wenhao Deng, Mengyuan Lu, Yutong Zhai, Feilong Pei, Shuang Liu, Chunping Zhang
Summary: Swietenine can alleviate inflammation and oxidative stress, and improve diabetic nephropathy by inhibiting the activation of NE-kappa B and NLRP3 through regulating the NF-kappa B/NLRP3/Caspase-1 signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Chun Gao, Jianhua Deng, Hanchenxi Zhang, Xinran Li, Shuchen Gu, Mingjie Zheng, Mei Tang, Yezhang Zhu, Xin Lin, Jianping Jin, Long Zhang, Jun Huang, Jian Zou, Zong-Ping Xia, Ping-Long Xu, Li Shen, Bin Zhao, Xin-Hua Feng
Summary: The study identified HSPA13 as a transcription-independent checkpoint to modulate the role of RIP1 in TNF alpha signaling, enhancing RIP1 recruitment to TNFR1 and promoting NF-kappa B transcriptional responses, while attenuating RIP1 participation in cytosolic complex II to prevent programmed cell death. Loss of HSPA13 shifts RIP1 from complex I to complex II, increasing apoptosis and necroptosis levels. The research provides compelling evidence for the cellular protective function of HSPA13 in fine-tuning TNF alpha responses.
Article
Urology & Nephrology
Yuxiang Liu, Wenyuan Liu, Ziyuan Zhang, Yaling Hu, Xiaodong Zhang, Yanyan Sun, Qingqing Lei, Dalin Sun, Ting Liu, Yanjun Fan, Hui Li, Wujie Ding, Jingai Fang
Summary: Yishen capsule improves diabetic nephropathy by promoting podocyte autophagy via the SIRT1/NF-kappa B pathway, relieving pathological changes and reducing urine protein levels.
Article
Medicine, General & Internal
Hina Ahsan, Shaukat Iqbal Malik, Fawad Ali Shah, Hamed A. El-Serehy, Amin Ullah, Zafar Abbas Shah
Summary: This study investigates the expression profiling of NF-kappa B p65 (RelA) and TNF alpha, as well as the effectiveness of Celecoxib in combination with Temozolomide in reducing the growth of human GBM cell line SF-767. The results demonstrate that Celecoxib reduces cell viability, cell proliferation, and the expression of NF-kappa B p65 (RelA) and TNF alpha in a dose-dependent manner. These findings suggest that Celecoxib therapy could mitigate the invasive characteristics of GBM cells by inhibiting the inflammatory cascade mediated by NF-kappa B.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ola S. Mohamed, Nayira A. Abdel Baky, Mohamed M. Sayed-Ahmed, Aya H. Al-Najjar
Summary: This study demonstrates the renoprotective effect of lactoferrin against cyclophosphamide-induced nephropathy. Lactoferrin reduces kidney injury markers, enhances antioxidant capacity, suppresses inflammation and apoptosis, and modulates multiple signaling pathways.
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.