Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Volodymyr V. Balatskyi, Vasyl O. Vaskivskyi, Anna Myronova, Diana Avramets, Karim Abu Nahia, Larysa L. Macewicz, Tetiana P. Ruban, Dar'ya Yu Kucherenko, Oleksandr O. Soldatkin, Iryna Lushnikova, Galyna G. Skibo, Cecilia L. Winata, Pawel Dobrzyn, Oksana O. Piven
Summary: The beta-Catenin signaling pathway plays a crucial role in regulating metabolic processes in cardiomyocytes. Disruption of this pathway leads to disturbances in energy substrate utilization, hindering postnatal heart maturation and causing perinatal lethality in homozygous beta-catenin knockout mice.
Article
Cell & Tissue Engineering
Dongsheng Cai, Xiaochen Wang, Yaxun Sun, Hangping Fan, Jingjun Zhou, Zongkuai Yang, Hangyuan Qiu, Jue Wang, Jun Su, Tingyu Gong, Chenyang Jiang, Ping Liang
Summary: Aberrant activation of Wnt/β-catenin signaling contributes to the pathogenesis of SCN5A-related BrS, suggesting it as a potential therapeutic target.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Jian Hou, Suiqing Huang, Yan Long, Kangni Feng, Liqun Shang, Zhuoming Zhou, Yuan Yue, Xiaolin Huang, Guangxian Chen, Zhongkai Wu
Summary: In this study, we investigated the role of DACT1 and its connection with beta-catenin and connexin 43 in human-derived cardiomyocytes. The findings suggest that DACT1 interacts with beta-catenin and connexin 43 in differentiated cardiomyocytes.
Article
Biotechnology & Applied Microbiology
Sumathi Poleboina, Vaibhav G. Sheth, Nisha Sharma, Praveer Sihota, Navin Kumar, Kulbhushan Tikoo
Summary: Selenium nanoparticles (SeNPs) promote osteoblast differentiation and mineralization, and preserve bone microstructure and biomechanical stability, suggesting their therapeutic potential in the management of diabetes-associated osteoporosis.
Article
Cell Biology
Huaji Jiang, Jialiang Zhong, Wenjun Li, Jianghui Dong, Cory J. Xian, Yung-Kang Shen, Lufeng Yao, Qiang Wu, Liping Wang
Summary: The study found that GEN can promote osteogenesis of BMSCs by activating the BMP and Wnt/β-catenin pathways, providing a novel strategy for the treatment of osteoporosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yanhua Tang, Nan Nan, Chuanzhi Gui, Xuan Zhou, Wenyong Jiang, Xiaoqian Zhou
Summary: This study demonstrates that upregulating FERMT3 can inhibit chemoresistance in colorectal cancer cells and enhance the immune response of NK cells against tumor cells. By inhibiting the Wnt/β-catenin-PD-L1 signaling pathway, upregulation of FERMT3 may be a promising therapeutic approach to overcome chemoresistance and immune evasion in colorectal cancer.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Su Bin Hwang, Hyeon Ju Park, Bog-Hieu Lee
Summary: Fish-derived collagen is an effective alternative source of collagen with bioactive properties that enhance hair and skin health. It has a higher bioavailability and fewer side effects compared to collagen from porcine or bovine sources. This study evaluated the effects of collagen peptides (CPs) extracted from Mozambique tilapia scales on hair growth using in vitro and in vivo models. The results showed that CP significantly promoted hair regrowth and the proliferation of human dermal papilla cells (hDPCs) in vitro. Oral administration of CP to mice also confirmed its hair growth-promoting effects. CP treatment increased the expression of hair growth factors and pathways while decreasing the growth inhibitory factor. These findings suggest that CP could be used as a food supplement or nutraceutical for preventing hair loss and promoting hair regrowth in cases of alopecia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Yutthana Pengjam, Nurul Syazwani, Jakkapong Inchai, Amornkan Numit, Thanintorn Yodthong, Thanawat Pitakpornpreecha, Pharkphoom Panichayupakaranant
Summary: The study demonstrated that CRE-SD promoted osteoblast differentiation in MC3T3-E1 cells and showed activity in various cell types, with mechanisms involving induction of cells into osteoblasts through the Wnt/beta-catenin and BMP signaling pathways.
CHINESE HERBAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Zhibing Qiu, Wen Chen, Yafeng Liu, Ben Jiang, Li Yin, Xin Chen
Summary: The down-regulated lncRNA AC061961.2 in dilated cardiomyopathy (DCM) patients has a regulatory effect on DCM. Overexpression of AC061961.2 can inhibit endoplasmic reticulum stress-induced apoptosis in DCM rats and cardiomyocytes by activating the Wnt/beta-catenin pathway.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
(2021)
Article
Pharmacology & Pharmacy
Xiao-yun Zhang, Hua-nan Li, Feng Chen, Yue-ping Chen, Yuan Chai, Jian-zhao Liao, Bin Gan, Ding-peng Chen, Song Li, Yong-qian Liu
Summary: Icariin promotes BMSC viability and osteogenic differentiation by reducing miR-23a-3p levels and regulating the BMP-2/Smad5/Runx2 and WNT/8-catenin pathways, ultimately improving osteonecrosis of the femoral head.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Physiology
Aizhu Lu, Ruonan Gu, Cencen Chu, Ying Xia, Jerry Wang, Darryl R. Davis, Wenbin Liang
Summary: This study found that Wnt/β-catenin signaling pathway affects the fast Na+ current in cardiomyocytes by regulating the expression levels of Na(v)1.5 protein and SCN5A mRNA. Activation of Wnt/β-catenin signaling reduces Na(v)1.5 protein and SCN5A mRNA in healthy human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Inhibition of Wnt/β-catenin signaling increases Na(v)1.5 protein in iPSC-CMs from Brugada syndrome patients.
PHYSIOLOGICAL REPORTS
(2023)
Article
Cell Biology
Lianying Hu, Zhen Cheng, Lunan Wu, Liangliang Luo, Ping Pan, Shujin Li, Qiyu Jia, Ning Yang, Bin Xu
Summary: This study investigated the regulatory mechanism of histone methyltransferase SETDB1 in osteogenic differentiation in osteoporosis. Bioinformatics analysis revealed that SETDB1 may be involved in the development of osteoporosis. Experimental results showed that SETDB1 promotes osteogenic differentiation in osteoporosis by inhibiting OTX2 expression and activating the BMP-Smad and Wnt/β-catenin pathways.
Article
Multidisciplinary Sciences
Shuhei Konagaya, Takeshi Ando, Toshiaki Yamauchi, Hirofumi Suemori, Hiroo Iwata
SCIENTIFIC REPORTS
(2015)
Article
Developmental Biology
Takamichi Miyazaki, Norio Nakatsuji, Hirofumi Suemori
Article
Chemistry, Multidisciplinary
Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Article
Cell & Tissue Engineering
Norio Nakatsuji, Eihachiro Kawase, Takamichi Miyazaki, Itsunari Minami, Kazuhiro Aiba
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2013)
Article
Multidisciplinary Sciences
Hiroki Takeuchi, Norio Nakatsuji, Hirofumi Suemori
SCIENTIFIC REPORTS
(2014)
Article
Multidisciplinary Sciences
Takamichi Miyazaki, Takehisa Isobe, Norio Nakatsuji, Hirofumi Suemori
Scientific Reports
(2017)
Article
Cell Biology
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi
Article
Cell & Tissue Engineering
Jung-Hyun Kim, Alex Alderton, Jeremy M. Crook, Nissim Benvenisty, Catharina Brandsten, Meri Firpo, Peter W. Harrison, Shin Kawamata, Eihachiro Kawase, Andreas Kurtz, Jeanne F. Loring, Tenneille Ludwig, Jennifer Man, Joanne C. Mountford, Marc L. Turner, Steve Oh, Lygia da Veiga Pereira, Patricia Pranke, Michael Sheldon, Rachel Steeg, Stephen Sullivan, Michael Yaffe, Qi Zhou, Glyn N. Stacey
Article
Cell & Tissue Engineering
Kaori Yamauchi, Tatsuhiko Ikeda, Mihoko Hosokawa, Norio Nakatsuji, Eihachiro Kawase, Shinichiro Chuma, Kouichi Hasegawa, Hirofumi Suemori
Article
Cell & Tissue Engineering
Eihachiro Kawase, Kei Takada, Hirofumi Suemori
STEM CELL RESEARCH
(2020)
Article
Cell & Tissue Engineering
Eihachiro Kawase, Kei Takada, Ryoko Nakatani, Shizuka Yamazaki, Hirofumi Suemori
Summary: KthES11 is a human embryonic stem cell line derived from a normal healthy blastocyst donated for clinical research. It was isolated, propagated, and stored without feeders in an animal product-free environment according to cGMP standards. The cell line demonstrates normal karyotype, pluripotency, and the ability to differentiate into the three germ layers, and has been validated for sterility and absence of mycoplasma, antibiotic residues, and specific human pathogens.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Jung-Hyun Kim, Eihachiro Kawase, Kapil Bharti, Ohad Karnieli, Yuji Arakawa, Glyn Stacey
Summary: This report summarizes key issues discussed at a workshop organized by the International Stem Cell Banking Initiative (ISCBI) in Korea, highlighting the full range of costs and challenges related to preparing human pluripotent stem cell lines for cell therapy manufacturing. Global experts shared experiences on cost management and opportunities for reducing costs during the clinical application stage.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Cell & Tissue Engineering
Kei Takada, Ryoko Nakatani, Emiko Moribe, Shizuka Yamazaki-Fujigaki, Mai Fujii, Masayo Furuta, Hirofumi Suemori, Eihachiro Kawase
Summary: This article introduces the establishment of clinical-grade human embryonic stem cell lines KthES11 in Japan according to good manufacturing practice standards. By using xeno-free chemically defined medium and optimizing the protocol, they successfully established five hESC lines, which are of great significance for human pluripotent stem cell therapy applications.
REGENERATIVE THERAPY
(2022)
Review
Materials Science, Biomaterials
Eihachiro Kawase, Norio Nakatsuji
Summary: Although initially established using feeder cells, the development of culture media and substrates is crucial for the safe, stable, high-quality, and efficient production of human pluripotent stem cells (hPSCs). Researchers now culture hPSCs in chemically defined media and on substrates without feeder cells. This review discusses the issues with using Matrigel as a culture substrate, the development of extracellular matrix proteins and synthetic substrates as alternatives, and the importance of three-dimensional culture for mass production of hPSCs.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Di Mao, Shin Ando, Shin-ichi Sato, Ying Qin, Nao Hirata, Yousuke Katsuda, Eihachiro Kawase, Ting-Fang Kuo, Itsunari Minami, Yuji Shiba, Kazumitsu Ueda, Norio Nakatsuji, Motonari Uesugi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)