Article
Neurosciences
Xiaohu Xie, Jun Gu, Dingding Zhuang, Wenwen Shen, Longhui Li, Yue Liu, Wenjin Xu, Qingxiao Hong, Weisheng Chen, Wenhua Zhou, Huifen Liu
Summary: The study suggests a potential association between the rs13303344 SNP in GABRD gene and susceptibility to heroin addiction, with the C allele at this locus linked to an increased risk. However, after Bonferroni correction, this association lost significance. Additionally, specific haplotypes in the GARBD gene also showed significant differences between heroin dependent patients and controls.
NEUROSCIENCE LETTERS
(2021)
Article
Oncology
Felix P. Chilunga, Karlijn A. C. Meeks, Peter Henneman, Charles Agyemang, Ayo P. Doumatey, Charles N. Rotimi, Adebowale A. Adeyemo
Summary: This study utilized DNA methylation profiles of African American individuals to identify differentially methylated positions associated with insulin resistance. Two of the identified positions have not been reported in other populations. The findings suggest significant differences in DNA methylation patterns across different population groups.
CLINICAL EPIGENETICS
(2022)
Article
Biochemistry & Molecular Biology
Elsa Cortes-Montero, Maria Rodriguez-Munoz, M. Carmen Ruiz-Cantero, Enrique J. Cobos, Pilar Sanchez-Blazquez, Javier Garzon-Nino
Summary: TRPA1 channels are involved in nociceptive signaling, forming functional associations with MORs and NMDARs to promote pain transmission and modulate analgesic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Vadim Yuferov, Eduardo R. Butelman, Matthew Randesi, Jurg Ott, Mary Jeanne Kreek
Summary: This study identified associations between several SNPs in intron 2 of the OPRK1 gene and cocaine dependence diagnoses, but not opioid dependence; individuals with certain genotypes also showed greater exposure to cocaine.
NEUROSCIENCE LETTERS
(2022)
Article
Multidisciplinary Sciences
Nathan Gaddis, Ravi Mathur, Jesse Marks, Linran Zhou, Bryan Quach, Alex Waldrop, Orna Levran, Arpana Agrawal, Matthew Randesi, Miriam Adelson, Paul W. Jeffries, Nicholas G. Martin, Louisa Degenhardt, Grant W. Montgomery, Leah Wetherill, Dongbing Lai, Kathleen Bucholz, Tatiana Foroud, Bernice Porjesz, Valgerdur Runarsdottir, Thorarinn Tyrfingsson, Gudmundur Einarsson, Daniel F. Gudbjartsson, Bradley Todd Webb, Richard C. Crist, Henry R. Kranzler, Richard Sherva, Hang Zhou, Gary Hulse, Dieter Wildenauer, Erin Kelty, John Attia, Elizabeth G. Holliday, Mark McEvoy, Rodney J. Scott, Sibylle G. Schwab, Brion S. Maher, Richard Gruza, Mary Jeanne Kreek, Elliot C. Nelson, Thorgeir Thorgeirsson, Kari Stefansson, Wade H. Berrettini, Joel Gelernter, Howard J. Edenberg, Laura Bierut, Dana B. Hancock, Eric Otto Johnson
Summary: In this study, genomic structural equation modeling was used to conduct a genome-wide association study of opioid addiction (OA) phenotypes. Significant associations were found between OA and the genes OPRM1, PPP6C, and FURIN, suggesting pleiotropy in addiction and related traits.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Anastasia Levinta, Shakila Meshkat, Roger S. McIntyre, Cameron Ho, Leanna M. W. Lui, Yena Lee, Rodrigo B. Mansur, Kayla M. Teopiz, Nelson B. Rodrigues, Joshua D. Di Vincenzo, Felicia Ceban, Joshua D. Rosenblat
Summary: Ketamine has demonstrated antidepressant efficacy in patients with treatment-resistant depression, although its effectiveness may be affected by the level of treatment resistance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Deepa Gautam, Ulhas P. Naik, Meghna U. Naik, Santosh K. Yadav, Rameshwar Nath Chaurasia, Debabrata Dash
Summary: This paper explores the role of platelets in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as the critical role of glutamate receptors in the pathophysiology of these diseases. By reviewing data from clinical trials, animal models, and cellular studies, it reveals the involvement of glutamate receptor dysfunction in neurodegenerative processes and provides an overview of current treatments, including glutamate receptor antagonists, for AD and PD.
Article
Environmental Sciences
Dilek Kaya-Akyuzlu, Selin Ozkan-Kotiloglu, Ceylan Bal, Safak Yalcin-Sahiner, Gamze Avcioglu, Mustafa Danisman
Summary: This study investigated the effects of UGT2B7 gene polymorphisms on sublingual BUP/naloxone treatment in patients with OUD. The findings suggest that certain genotypes are associated with lower plasma BUP levels and increased craving and withdrawal symptoms.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, Xiangning Cui
Summary: This article reviews the glutamate-mediated excitotoxicity mechanism in post-ischemic stroke damage, focusing on the pathological changes in glutamate release, reuptake, NMDAR, and cellular signaling pathways. It also discusses new treatment targets and potential neuroprotective drugs for ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Remy A. Yovanno, Tsung Han Chou, Sarah J. Brantley, Hiro Furukawa, Albert Y. Lau
Summary: This study investigated the mechanisms of D-serine in receptor activation and found that D-serine competes with glutamate for binding to GluN2A. The inhibitory effect of D-serine at high concentrations was confirmed through electrophysiology experiments.
Article
Pharmacology & Pharmacy
Xiaohu Xie, Jun Gu, Dingding Zhuang, Xiaoyu Chen, Yun Zhou, Wenwen Shen, Longhui Li, Yue Liu, Wenjin Xu, Qingxiao Hong, Weisheng Chen, Wenhua Zhou, Huifen Liu
Summary: This study aimed to investigate the impact of gene variants in the GABA receptor delta subunit (GABRD) on treatment response and dose in methadone maintenance treatment for heroin addiction. The results indicated that GABRD variants may play a role in modulating treatment response.
PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Deji Cuola, Yunxiao Li, Chen Yuanyuan, Lai Jianghua, Wei Shuguang
Summary: Heroin use disorder is a chronic relapsing brain disease with different phenotypes among users, possibly influenced by genetic factors. Polymorphisms of COMT and ADRA1A genes have been found to be associated with specific phenotypes of heroin use disorder, such as duration of transition to addiction, memory impairment, and daily dose of heroin. This study provides valuable insights for precise treatment of heroin use disorder based on individual genetic markers.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hikaru Koizumi, Taichi Hiraga, Leandro K. Oharomari, Toshiaki Hata, Takeru Shima, Jang Soo Yook, Masahiro Okamoto, Akihiro Mouri, Toshitaka Nabeshima, Hideaki Soya
Summary: Schizophrenia may be attributed to perinatal neurodevelopmental deficits and influenced by environmental factors. Hypofrontality and dysfunction in glutamatergic and dopaminergic neurons are known factors, while early enriched environment and low-intensity exercise training during adolescence may help prevent and ameliorate the disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Neurosciences
Yevheniia Ishchenko, Melissa G. Carrizales, Anthony J. Koleske
Summary: Excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDARs) is essential for synapse development, function, and plasticity in the brain. Genetic variants in NMDAR subunit genes are associated with various neurodevelopmental and neuropsychiatric disorders. The carboxyl terminal domain (CTD) of NMDAR subunits plays a crucial role in regulating receptor functions.
Article
Pharmacology & Pharmacy
Kwang-Hyun Hur, Seong-Eon Kim, Shi-Xun Ma, Bo-Ram Lee, Yong-Hyun Ko, Jee-Yeon Seo, Seon-Kyung Kim, Young-Jung Kim, Su-Jeong Sung, Youyoung Lee, Young Hoon Jung, Yong-Sup Lee, Seok-Yong Lee, Choon-Gon Jang
Summary: The study demonstrates that methoxphenidine exhibits addictive and schizophrenia-like behaviors, inducing neurochemical changes in brain regions associated with these behaviors. These findings suggest that methoxphenidine could be utilized in developing animal disease models and calls for legal restrictions on its recreational use.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)