Article
Cell Biology
Maciej Sobczak, Magdalena Strachowska, Karolina Gronkowska, Iwona Karwaciak, Lukasz Pulaski, Agnieszka Robaszkiewicz
Summary: The study shows that activation of toll-like receptors with LPS leads to a decline in the transcription of hydrogen peroxide decomposing enzyme-catalase, promoting polarization of human macrophages towards the pro-inflammatory phenotype. Inhibition of LSD1 activity in LPS-stimulated macrophages can negatively control expression of key pro-inflammatory markers.
Article
Pharmacology & Pharmacy
Xiangyu Zhang, Xinran Wang, Tianxiao Wu, Wenbo Yin, Jiangkun Yan, Yixiang Sun, Dongmei Zhao
Summary: This study provides an extensive review of LSD1 as an important histone demethylase in cancer and its potential applications. The aberrant overexpression of LSD1 in tumor cells is associated with tumor growth, invasion, and metastasis, making it a promising target for cancer therapy. The review summarizes recent advances in LSD1 inhibitors, including their structural characteristics, screening methods, and future directions for development.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ivan K. Domingo, Asna Latif, Amit P. Bhavsar
Summary: Cisplatin, a widely used chemotherapeutic drug, is effective against various solid cancers but limited by its adverse drug reactions. The most common reactions include nephrotoxicity, peripheral neuropathy, and ototoxicity. Previous studies focused on oxidative stress as the cause of these toxicities, but recent evidence suggests that inflammation may be the main driving force. This review summarizes the common and distinct inflammation characteristics among different adverse reactions, as well as current treatments targeting pro-inflammatory signaling pathways to improve the use of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Biochemistry & Molecular Biology
Qiaoman Fei, Manman Qiu, Guanwei Fan, Bo Zhang, Qin Wang, Sipei Zhang, Shuying Wang, Bing Yang, Ling Zhang
Summary: Previous studies have shown that LSD1 can regulate cell cycle progression through demethylation, and its interaction with Hotair in mice's myocardial regeneration process may play a critical role. The study reveals that the high expression of Hotair and Lsd1 in the myocardial tissue within 1 week after birth is consistent with the time window for myocardial regeneration in neonatal mice. Knockdown of Lsd1 or Hotair expression could inhibit myocardial regeneration and cardiomyocyte proliferation, suggesting that Hotair-mediated demethylation of LSD1 may be important for myocardial regeneration in neonatal mice.
DNA AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rafael Cardoso Maciel Costa Silva, Luis Tan, Danielle Aparecida Rodrigues, Elisa Beatriz Prestes, Caroline Pereira Gomes, Andreza Moreira Gama, Pedro Lagerblad de Oliveira, Claudia Neto Paiva, Benedicte Manoury, Marcelo Torres Bozza
Summary: The study indicates that chloroquine may be used as a supportive therapy to control heme-induced deleterious inflammation in different hemolytic diseases by inhibiting inflammatory effects induced by heme.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jiebo Zhu, Min Joung Lee, Jong Hun An, Eungseok Oh, Woosuk Chung, Jun Young Heo
Summary: Microglial activation is correlated with the unfolded protein response (UPRmt) in mitochondria, which acts as a protective mechanism during neuroinflammation and may be a potential therapeutic target for reducing inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fengting Liu, Xiaofang Ma, Xiyun Bian, Chunyan Zhang, Xiaozhi Liu, Qiang Liu
Summary: This study aimed to uncover the epigenetic regulation mechanism of the LINC00586/LSD1/ASXL1 axis in colorectal cancer (CRC). The results revealed that LINC00586 overexpression was associated with CRC patient survival, and silencing LINC00586 could inhibit the viability and migration of CRC cells, thereby limiting CRC metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Andrea Gerbino, Cinzia Forleo, Serena Milano, Francesca Piccapane, Giuseppe Procino, Martino Pepe, Mara Piccolo, Piero Guida, Nicoletta Resta, Stefano Favale, Maria Svelto, Monica Carmosino
Summary: The study identified high levels of G-CSF and IL-6 in all patients with lmna mutations, as well as elevated levels of other interleukins and GM-CSF in patients with more aggressive clinical manifestations. Furthermore, increased expression of Hsp70 in serum exosomes was observed in patients with the more severe phenotype, suggesting potential diagnostic, prognostic, and therapeutic implications against Lamin A/C cardiomyopathies.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roberto Gramignoli, Aarati R. Ranade, Raman Venkataramanan, Stephen C. Strom
Summary: Pro-inflammatory cytokines can affect liver cell functions, particularly ammonia and drug metabolism, but do not necessarily indicate rejection or loss of cell graft.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Narges Navaei-Alipour, Mohadeseh Mastali, Gordon A. Ferns, Maryam Saberi-Karimian, Majid Ghayour-Mobarhan
Summary: Honey contains flavonoids and phenolic acids that may have important implications for human health due to their antioxidant and anti-inflammatory properties. Studies have shown that honey can inhibit the expression of pro-inflammatory factors in conditions such as cancer and neuro-inflammatory disorders. However, more high-quality research is needed to firmly establish the clinical efficacy of honey and understand the specific mechanisms of its anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yue Wang, Yunchao Huang, Edith Cheng, Xinhua Liu, Yu Zhang, Jianguo Yang, Jordan T. F. Young, Grant W. Brown, Xiaohan Yang, Yongfeng Shang
Summary: This study reveals an unexpected role for lysine-specific demethylase 1 (LSD1) in euchromatic origin firing and replication timing, highlighting the importance of epigenetic regulation in the activation of replication origins. The findings support the potential use of selective inhibitors of LSD1 in cancer therapy, while emphasizing the need to maintain an appropriate level of LSD1 to minimize side effects.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)