Article
Medicine, General & Internal
Sul-Hee Lee, Youin Bae, Young-Lip Park
Summary: This study found a negative correlation between serum adiponectin levels and disease severity and pruritus in AD patients. However, no significant effects were observed with biologic treatment for AD. Therefore, adiponectin may serve as a potential biomarker for severity assessment in AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Hsun-Chin Chao, Jang-Jih Lu, Chang-Yo Yang, Pai-Jui Yeh, Shih-Ming Chu
Summary: The study found that zinc deficiency in children is significantly associated with picky eating behavior, development level, and physical activity level, with a particularly high prevalence in picky eaters. Zinc deficiency was found to be significantly related to low development and poor physical activity in early childhood.
Article
Nutrition & Dietetics
Lorena Desdentado, Jaime Navarrete, Maria Folgado-Alufre, Ana de Blas, Jessica Navarro-Siurana, Francisco Ponce, Guadalupe Molinari, Andrea Jimeno-Martinez, Azahara I. Ruperez, Gloria Bueno-Lozano, Aida Cuenca-Royo, Emili Corbella, Zaida Aguera, Rosa M. Banos, Julio Alvarez-Pitti
Summary: This study found that higher levels of ghrelin concentration were associated with lower scores in restrained eating. No other relationships were found between obesity-related biomarkers and eating behaviors.
Article
Environmental Sciences
Jiao Bi, Fei Wang, Yue Wei, Ying Zhang, Chengyong Jia, Jia He, Jinqiu Yao, Zefang Zhang, Zhaoyang Li, Peiwen Li, Meian He
Summary: This study found a positive association between serum bisphenol A (BPA) and incident overweight and obesity risk in a non-monotonic pattern in the Chinese population. Adiponectin may mediate the association.
Review
Endocrinology & Metabolism
Jiangna Wang, Shiwei Liu, Yuxiang Zhao, Syed Shah Zaman Haider Naqvi, Ruixue Duan
Summary: This meta-analysis explores the relationship between adipokines levels (leptin, adiponectin, and chemerin) and the incidence of senile osteoporosis. The findings indicate that older individuals with lower levels of leptin and higher levels of chemerin are more likely to have senile osteoporosis. Additionally, there is a significant positive correlation between levels of leptin and adiponectin and body mass index.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Maria Luisa Vazquez-Villegas, Jorge Gamez-Nava, A. Miriam Saldana-Cruz, Alfredo Celis, Esther N. Sanchez-Rodriguez, Edsaul Emilio Perez-Guerrero, Melissa Ramirez-Villafana, Cesar Arturo Nava-Valdivia, Betsabe Contreras-Haro, Jose C. Vasquez-Jimenez, Juan M. Ponce-Guarneros, Ana K. Barocio-Ramirez, Sergio Cerpa-Cruz, Miriam F. Alcaraz-Lopez, Laura Gonzalez-Lopez
Summary: High chemerin levels are associated with functional disability in RA, while other pro-inflammatory molecules are not correlated with loss of function. Chemerin is correlated with HAQ-DI and DAS28-ESR, and severe activity is correlated with IL-6 and E-selectin.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Shiro Fukuda, Shunbun Kita, Kazuya Miyashita, Masahito Iioka, Jun Murai, Tadashi Nakamura, Hitoshi Nishizawa, Yuya Fujishima, Jun Morinaga, Yuichi Oike, Norikazu Maeda, Iichiro Shimomura
Summary: Three novel forms of soluble T-cad were identified in human serum. The importance of these forms as disease markers and/or biomarkers of adiponectin function, as well as the potential bioactivity of the respective molecules, require further investigation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Loes M. E. Moolhuijsen, Yvonne Louwers, Anke McLuskey, Linda Broer, Andre G. Uitterlinden, Renee M. G. Verdiesen, Ryan K. Sisk, Andrea Dunaif, Joop S. E. Laven, Jenny A. Visser
Summary: A novel AMH promoter polymorphism rs10406324 is associated with lower serum AMH levels in patients with PCOS, suggesting its role in the regulation of AMH gene expression.
HUMAN REPRODUCTION
(2022)
Article
Clinical Neurology
Solveig Magnusdottir, Robert Joseph Thomas, Hugi Hilmisson
Summary: The study found that improving sleep quality based on cardiopulmonary coupling analysis (CPC) is associated with higher serum adiponectin levels, which may have beneficial effects on metabolic syndrome and cardiovascular health.
Article
Chemistry, Analytical
Bahar Ince, Mustafa Kemal Sezginturk
Summary: This study developed a novel biosensor for detecting adiponectin levels, aiming to prevent and treat cardiovascular diseases, immune disorders, and joint disorders related to obesity. By using PET sheets covered with ITO as the working electrode and stabilizing a layer of anti-adiponectin using 3-GOPS, the immunosensor preparation was proven successful under optimal conditions. The designed biosensor showed a wide response range to adiponectin concentrations and was applied successfully to real human serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Hyun Suk Yang, Gun-Hyuk Lee, Donghwan Kim, Kyeong Ryong Lee, Mina Hur
Summary: Adiponectin could be a potential biomarker for multi-MetSC in general health checkup subjects with extremely high HDL-C levels, and there are sex differences in the manifestation of metabolic risk factors.
Article
Endocrinology & Metabolism
Kangkang Huang, Yunlai Liang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi
Summary: This study discovered significant variations in adiponectin, nesfatin-1, IL-6, and TNF-alpha levels among healthy individuals, prediabetic patients, and type 2 diabetes mellitus patients, indicating a gradual change during the progression from a healthy condition to diabetes via prediabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chen-Jung Wu, A-Chuan Ho, Shih-Ya Chen, Chih-Hong Pan, Hsiao-Chi Chuang, Ching-Huang Lai
Summary: It was found that workers exposed to metal fumes had an increased risk of metabolic syndrome, which was correlated with decreased serum adiponectin levels. Therefore, the study aimed to investigate the impact of heavy metal exposure on adiponectin levels.
Article
Cell Biology
Linyuan Shu, Yimu Fu, Hui Sun
Summary: This meta-analysis study found that individuals with postmenopausal osteoporosis (PMOP) have lower blood leptin levels and higher adiponectin levels compared to healthy individuals with normal bone mineral density. The statistical difference in leptin level changed after removing the confounding influence of leptin sources and assay approaches. The study also found a positive association between leptin level and body mass index (BMI), and a negative association between adiponectin level and bone mineral density (BMD). Adiponectin had the highest probability of predicting PMOP.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lijuan Quan, Yue Zhao, Jinping Yi, Xiao-Dong Shi, Yingjun Zhong, Lingling Liu
Summary: This study found that serum adiponectin levels are decreased in children with ASD compared to healthy children, and there is an inverse association between serum adiponectin levels and severity of symptoms in ASD.
METABOLIC BRAIN DISEASE
(2021)
Article
Neurosciences
Natalie Kohler, Giacomo Novembre, Katarzyna Gugnowska, Peter E. Keller, Arno Villringer, Daniela Sammler
Summary: Joint music performance requires flexible sensorimotor coordination between self and other, influenced by shared knowledge and temporal synchrony. A study found that pianists who practiced their partner's part showed stronger activity and connectivity within cortico-cerebellar audio-motor networks, indicating internal model simulation and anticipation of partner's feedback. However, when there were subtle asynchronies between model-based anticipations and perceived sensory outcomes of partner actions, pianists exhibited stronger cerebellar activity and reduced behavioral adaptation, indicating a shift towards self-other segregation.
Article
Genetics & Heredity
Janine Molder, Esther Guiu-Jurado, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Peter Kovacs, Matthias Blueher, Nora Kloeting
Summary: This study aimed to investigate the influence of SNP rs10487505 on leptin mRNA expression and obesity-related parameters. The researchers found that rs10487505 is associated with lower leptin levels in women and a lower mean BMI in women carrying the C allele. However, no association was found between rs10487505 and leptin mRNA expression in adipose tissue.
Article
Neurosciences
Ahmed A. Khalil, Ayse C. Tanritanir, Ulrike Grittner, Evgeniya Kirilina, Arno Villringer, Jochen B. Fiebach, Ralf Mekle
Summary: In this study, the reproducibility of BOLD delay was assessed in 136 subjects with normal cerebral perfusion. The highest reproducibility was observed in the posterior cerebral artery territory. Overall, BOLD delay showed good reproducibility, but caution should be exercised when interpreting longitudinal BOLD delay changes that are either very small or located in certain brain regions.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Inka Rapoehn, Ivet Elias, Juliane Weiner, Anna Pujol, Stephanie Kehr, Alexandra Chadt, Hadi Al-Hasani, Ralph Burkhardt, Nora Kloeting, Michael Stumvoll, Fatima Bosch, Peter Kovacs, John T. Heiker, Jana Breitfeld
Summary: Adipose tissue inflammation and insulin resistance are important factors in the development of metabolic diseases resulting from overweight and obesity. The serpin vaspin has compensatory roles in inflammation and insulin resistance. A new transgenic mouse line with human vaspin expression in adipose tissue has been developed, which showed improved metabolic parameters and increased energy expenditure under high-fat diet conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marleen Wuerfel, Matthias Blueher, Michael Stumvoll, Thomas Ebert, Peter Kovacs, Anke Toenjes, Jana Breitfeld
Summary: Adipokines play a crucial role in the development of obesity and its associated metabolic and cardiovascular complications. While some adipokines have been identified and studied, many regulatory mechanisms remain unclear, hindering their clinical application. However, due to their complex metabolic properties, adipokines hold great potential as biomarkers and treatment strategies for obesity and related disorders. This review summarizes current clinical studies on adipokines and their potential diagnostic and therapeutic use in obesity and metabolic disorders, highlighting the promising clinical application of fibroblast growth factors (FGF)-19, FGF-21, and leptin.
Article
Endocrinology & Metabolism
Haiko Schloegl, Arno Villringer, Konstanze Miehle, Mathias Fasshauer, Michael Stumvoll, Karsten Mueller
Summary: This study replicated previous findings on the increase of brain connectivity in the hypothalamus and posterior cingulate gyrus in patients with lipodystrophy (LD) undergoing metreleptin treatment. These results contribute to understanding the central nervous effects of leptin and provide a foundation for future research.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
Haiko Schloegl, Lieneke Janssen, Mathias Fasshauer, Konstanze Miehle, Arno Villringer, Michael Stumvoll, Karsten Mueller
Summary: Using functional MRI, the study investigated the effects of metreleptin on the reward system in a non-eating behavior reward task. The results showed that patients with lipodystrophy treated with metreleptin experienced a decrease in reward-related brain activity, suggesting that leptin has functions in the human reward system that are unrelated to eating behavior.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Health Care Sciences & Services
Maximiliane Chiara Hammel, Robert Stein, Juergen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Toenjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blueher, Wieland Kiess, Antje Koerner
Summary: The study aimed to establish reference ranges for fasting insulin indices across all age ranges and evaluate their clinical application in predicting glycemic deterioration in children. The results showed that insulin resistance in children with obesity doubled the risk for future glycemic deterioration, and insulin-based indices were better predictors of dysglycemia than fasting glucose alone.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Clinical Neurology
Karsten Mueller, Friederike Thiel, Birol Taskin, Frank Beutner, Andrej Teren, Vladimir K. Dubovoy, Harald E. Moeller, Arno Villringer, Matthias L. Schroeter
Summary: The study aimed to detect the functional correlates of heart failure in terms of alterations in functional brain connectivity related to cognitive performance. The results show that heart failure is associated with reduced functional connectivity between the precuneus and widely distributed brain regions, and decline in cognitive performance is specifically correlated with diminished functional brain connectivity in patients with heart failure.
BRAIN COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blueher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Frank B. Hu, Meir J. Stampfer, Peter Kovacs, Liming Liang, Iris Shai
Summary: This study found that Mediterranean and green-MED diets with increased polyphenols intake are inversely associated with biological aging. To the best of our knowledge, this is the first clinical trial to indicate a potential link between polyphenol intake, urine polyphenols, and biological aging.
Article
Gastroenterology & Hepatology
Evelyn Medawar, Frauke Beyer, Ronja Thieleking, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Madlen Reinicke, Rima Chakaroun, Martin von Bergen, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the effects of high-dosed prebiotic fiber on reward-related food decision-making in overweight young adults. The results showed that prebiotic intake decreased brain activation towards high-caloric food stimuli and caused shifts in gut microbiota.
Article
Neurosciences
Julia Huck, Anna-Thekla Jaeger, Uta Schneider, Sophia Grahl, Audrey P. Fan, Christine Tardif, Arno Villringer, Pierre-Louis Bazin, Christopher J. Steele, Claudine J. Gauthier
Summary: Resting-state functional magnetic resonance imaging (rs-fMRI) is used to detect low-frequency fluctuations in the BOLD signal across brain regions. Venous biases can affect the amplitude and location of the BOLD signal, as well as connectivity measures derived from rs-fMRI. This study investigated the impact of vein diameter and distance on various rs-fMRI measures in the grey matter. It was found that smaller veins had higher values across all distances, while values associated with larger veins decreased with increasing distance. Models were proposed to correct for this venous bias in rs-fMRI metrics.
HUMAN BRAIN MAPPING
(2023)
Article
Psychology, Biological
Felix Klotzsche, Michael Gaebler, Arno Villringer, Werner Sommer, Vadim Nikulin, Sven Ohl
Summary: Virtual reality (VR) is a powerful tool for studying cognitive processes, allowing researchers to observe behaviors and mental states in complex and controlled scenarios. This study used a VR headset to investigate the spatial limitations of two well-known EEG markers in visual short-term memory. The results showed that the amplitude of the contralateral delay activity (CDA) differed between high and low memory load at smaller eccentricities, but not at the largest eccentricity. Memory load and eccentricity had no significant effect on lateralized alpha power. The study concluded that commercial VR hardware can be used to study these EEG markers of visual memory, with some limitations.
Article
Food Science & Technology
Evelyn Medawar, Marie Zedler, Larissa de Biasi, Arno Villringer, A. Veronica Witte
Summary: Adopting plant-based diets high in fiber may reduce global warming and obesity prevalence, but the physiological and psychological determinants of plant-based food intake remain unclear.
NPJ SCIENCE OF FOOD
(2023)
Meeting Abstract
Ophthalmology
Yan Luo, Franziska G. Rauscher, Tobias Elze, Yu Tian, Min Shi, Saber Kazeminasab Hashemabad, Mohammad Eslami, Kerstin Wirkner, Thomas Peschel, Michael Stumvoll, Berend Isermann, Matthias Blueher, Markus Loeffler, Toralf Kirsten, Thomas Ebert, Mengyu Wang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)