Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations

Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes

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Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers

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A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy

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The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

(2010) Ines Pagel-Langenickel et al.   ENDOCRINE REVIEWS

The multifaceted therapeutic potential of benfotiamine

(2010) Pitchai Balakumar et al.   PHARMACOLOGICAL RESEARCH

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by the Dual Endothelin Receptor Antagonist CPU0213 in Rats

(2008) Ming Xu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damagein vitro

(2008) Ursula Schmid et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation

(2008) Shuichi Ohtomo et al.   KIDNEY INTERNATIONAL

Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients

(2008) Nicole Schupp et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives

(2008) Marie-Laure Volvert et al.   BMC Pharmacology & Toxicology