Journal
GENES & GENOMICS
Volume 33, Issue 1, Pages 57-63Publisher
SPRINGER
DOI: 10.1007/s13258-010-0049-y
Keywords
Cattle; Growth traits; Mutation; PCSK1 gene; SSCP
Categories
Funding
- National 863 Program of China [2008AA101010]
- National Natural Science Foundation of China [30972080]
- National Key Technology RD Program [2008BADB2B03-19]
- Keystone Project of transfergene in China [2009ZX08009-157B, 2008ZX08007-002, 2009ZX08007-005B-07]
- MaTS-Beef Cattle System [Nycytx-38]
- Basic and Foreland Technology Study Program of Henan Province [072300430160]
- Natural science fund for colleges and universities in Jiangsu Province [09KJD180002]
- Graduated Students Research and Innovation Plan of Jiangsu Province [CX09S-044Z]
- Xuzhou Normal University [09YLA006]
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Proprotein convertase 1 (PCSK1) is an endopeptidase involved in proteolytic processing of peptide hormone precursors in granules of the regulated secretory pathway of endocrine cells and mutations in PCSK1 gene are thought to cause obesity. In the present study, based on PCR-SSCP and DNA sequencing methods, polymorphisms of the PCSK1 gene were detected in 858 individuals from five breeds (Nanyang cattle, Qinchuan cattle, Jiaxian cattle, Luxi cattle and Chinese Holstein). The results showed that only P-8 locus showed polymorphisms and 3 synonymous SNPs of PCSK1 gene were identified. Additionally, significant statistical difference was found in bovine birth weight and diplotype MM were 7.35% higher than diplotype XY.
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