Journal
GENES & DEVELOPMENT
Volume 23, Issue 9, Pages 1037-1041Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1806409
Keywords
Trypanosoma brucei; histone variants; histone modification; genome-wide ChIP-seq; transcription initiation; transcription termination
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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The long polycistronic transcription units of trypanosomes do not appear to be demarcated by the usual DNA motifs that punctuate transcription in familiar eukaryotes. In this issue of Genes & Development, Siegel and colleagues (pp. 1063-1076) describe a system for the demarcation of trypanosome transcription units based on the deposition and turnover of histone variants rather than on the binding of transcription factors. Replication-independent incorporation of histone variants and destabilization of nucleosomes is an emerging theme at promoters of more familiar eukaryotes, and it now appears that this system is an evolutionarily conserved mode of transcriptional punctuation.
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