Journal
GENERAL PHYSIOLOGY AND BIOPHYSICS
Volume 29, Issue 1, Pages 3-11Publisher
GENERAL PHYSIOL AND BIOPHYSICS
DOI: 10.4149/gpb_2010_01_3
Keywords
Mitochondria; Complex I; Respiratory chain; Apoptosis
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Funding
- Ministry of Education of Slovak Republic [VEGA 1/4255/07, VVCE 0064-07]
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The mitochondrial respiratory chain consists of five multi-subunit complexes embedded in the inner mitochondrial membrane. Complex 1 is the largest and most complicated proton pump of the respiratory chain encoded by both the mitochondrial and nuclear genomes. In this minireview, attention is given to recent knowledge on the structure, catalytic properties, supramolecular organisation of complex I and its possible role in the triggering of apoptosis.
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