Article
Environmental Sciences
Anita A. Thambirajah, Michael G. Wade, Jonathan Verreault, Nicolas Buisine, Veronica A. Alves, Valerie S. Langlois, Caren C. Helbing
Summary: This critical review highlights the complexity of Endocrine Disrupting Chemicals interfering with Thyroid Hormone function through interactions with other hormonal axes, and emphasizes the lack of data generated in non-mammalian vertebrate classes. With the availability of more genomics-based resources, better identification and delineation of EDC effects, modes of action, and identification of effective biomarkers suitable for HPT disruption is possible. The effects of EDCs are likely to cascade into a plurality of complex physiological effects, beyond the few variables tested within research studies.
ENVIRONMENTAL RESEARCH
(2022)
Review
Food Science & Technology
Antonio Casas-Rodriguez, Ana M. Camean, Angeles Jos
Summary: Microcystins and cylindrospermopsin can induce toxic effects in various systems and organs, including potential endocrine disruption. However, research on their endocrine disruption activity is limited and existing results are contradictory. Further studies are needed to assess the risks and understand the dose-response relationships.
Article
Biochemistry & Molecular Biology
Teresa Peluso, Valeria Nittoli, Carla Reale, Immacolata Porreca, Filomena Russo, Luca Roberto, Antonia Giacco, Elena Silvestri, Massimo Mallardo, Mario De Felice, Concetta Ambrosino
Summary: Early life exposure to Endocrine Disruptor Chemicals (EDCs), such as the pesticide Chlorpyrifos (CPF), has been found to affect thyroid activity, glucose metabolism, and lipid metabolism. In this study, the researchers investigated the effects of CPF exposure on the metabolism and signaling of thyroid hormones (THs) and lipid/glucose metabolism in mice. They found that these processes were altered in males that were exposed to CPF, leading to hypothyroidism and systemic hyperglycemia. Additionally, the researchers discovered that CPF affected glucose metabolism and TH levels through the modulation of FOXO1 activity in liver cells. These findings highlight the importance of considering the intergenerational and sex-specific effects of CPF exposure on metabolic homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Marine & Freshwater Biology
Tianyu Wang, Shanshan Wu, Jianjie Chen, Lijuan Li, Jinling Cao
Summary: This study investigated the alleviating effects of sesamin on thyroid endocrine disruption caused by fluoride in zebrafish. Sesamin significantly improved growth performance and reduced mortality rate in adults, while also improving hatching rate and body length and alleviating spinal curvature and cyst formation in embryos and larvae. It also alleviated damage to thyroid tissues, reduced oxidative stress, improved thyroid hormone imbalance, and reversed the expression of endocrine-related genes.
AQUATIC TOXICOLOGY
(2023)
Article
Engineering, Environmental
Yongwei Guo, Duan Gui, Xiyang Zhang, Wen Liu, Qiang Xie, Xinjian Yu, Yuping Wu
Summary: The study found that Indo-Pacific humpback dolphins in the Pearl River Estuary showed physiological responses to contaminant exposure and changes in food resources. For calves, cortisol levels were positively correlated with body length and annual calf mortality ratios, indicating high stress levels before death in years of high calf mortality. Diseased noncalves had significantly higher blubber cortisol levels, and there was a positive relationship between contaminant levels and cortisol levels in noncalves.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Yongwei Guo, Wei Shi, Zhiwei Liu, Xian Sun, Jiaxue Wu, Yuping Wu
Summary: The bans on BPA have led to the use of BPA alternatives and changed the environmental contamination of BPs. However, concerns have been raised about the toxicities of the emerging BPA alternatives and their effects on endocrine disruption. This study measured the concentrations of six BPs in stranded cetaceans in the South China Sea and found that large whales had higher BPs concentrations compared to small dolphins. The study also revealed a shift in BPs profiles and the continued disruption of endocrine hormones in finless porpoises.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Liang Zheng, Zhecun Wang, Rui Yang, Wanna Chen, Jing Zhang, Ruixia Li, Weiming Lv, Bo Lin, Jiajun Luo
Summary: This study investigates the relationship between per- and polyfluoroalkyl substance (PFAS) exposures and thyroid hormones (TH) and lipid levels. The results show that PFAS exposure is associated with both TH disorder and higher cholesterol levels. However, these two effects appear to be independent and do not interfere with each other.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Niedson Correia de Lima Junior, Juliana Franco Camilo, Pamella Rodrigues do Carmo, Marcelle Novaes de Andrade, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Lycia de Brito Gitirana, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves, Glaecir Roseni Mundstock Dias
Summary: Subacute exposure to lead acetate disrupts thyroid gland function in both sexes, leading to changes in learning and memory abilities.
ENVIRONMENTAL POLLUTION
(2021)
Article
Public, Environmental & Occupational Health
Carmen Freire, Fernando Vela-Soria, Francesca Castiello, Elena Salamanca-Fernandez, Raquel Quesada-Jimenez, Maria Cristina Lopez-Alados, Mariana F. Fernandez, Nicolas Olea
Summary: This study investigated the association between plasma concentrations of PFAS and serum levels of thyroid hormones in adolescent males. The results showed that exposure to PFAS was associated with an increase in free T4 levels in boys with lower iodine intake. However, the extent of these alterations remains uncertain due to the small sample size.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Toxicology
Davidson Peruci Moreira, Yves Moreira Ribeiro, Camila Stephanie Ferreira, Samyra Maria dos Santos Nassif Lacerda, Elizete Rizzo
Summary: This study aimed to investigate the effects of chronic exposure to environmentally relevant ACE concentrations on multiple reproductive parameters in zebrafish. The results showed that ACE impaired the reproductive performance of zebrafish, including a decrease in egg and sperm quantity and quality, as well as an imbalance of sex steroids and prostaglandin E-2 levels. These findings indicate the impact of ACE on the reproductive ability of aquatic species.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stefana Catalina Bilha, Simona Hogas, Mihai Hogas, Stefan Marcu, Letitia Leustean, Maria-Christina Ungureanu, Dumitru D. Branisteanu, Cristina Preda
Summary: Chronic kidney disease (CKD) is often associated with thyroid, adrenal, and gonadal dysfunction. Kidney transplant recipients (KTR) may experience persistent endocrine abnormalities. Poor thyroid function prior to transplantation may indicate delayed graft function, and structural anomalies may occur after transplantation, necessitating thyroid surveillance. While gonadal hormonal secretion recovers after renal transplantation, fertility may not be completely restored. Testosterone treatment can improve anemia and general symptoms in KTR with hypogonadism. Female KTR may still have abnormal uterine bleeding, which may be managed with estroprogestative administration. Glucocorticoid administration suppresses the hypothalamic-pituitary-adrenal axis in KTR, leading to metabolic syndrome. Clinicians should be aware of these endocrine abnormalities in KTR patients to ensure proper management and improve quality of life.
Article
Environmental Sciences
Jiefeng Tan, Chuyan Liang, Yanfang Guo, Hong Zou, Yuqi Guo, Jiahui Ye, Liping Hou, Xiaolan Wang
Summary: The detection of progestins in aquatic environments and its disruptive effects in fish have gained increasing attention. However, the effects of progestins on thyroid function and neurotoxicity in fish are not well understood. This study investigated the effects of gestodene (GES) on the thyroid endocrine and nervous systems of mosquitofish. The results showed that GES exposure caused a decrease in fish growth, reduced swimming activity, and altered hormone levels and brain transcriptional levels.
Article
Environmental Sciences
Jing Chang, Yifan Pan, Wentao Liu, Peng Xu, Wei Li, Bin Wan
Summary: The study found that lambda-cyhalothrin and its metabolite 3-phenoxybenzoic acid had different effects on the thyroid axis in Chinese lizards, with the former increasing hormone levels and gland height, while the latter caused minor changes. In silico simulations showed that the two substances disrupt the HPT axis in lizards through distinct mechanisms.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Mang Sun, Xining Cao, Yuhao Wu, Lianju Shen, Guanghui Wei
Summary: Prenatal exposure to organochlorines and PFAS may be associated with lower neonatal TT4 levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biology
Chuang Shi, Qiyong Lou, Beide Fu, Junyan Jin, Jianfei Huang, Yao Lu, Xia Jin, Jiangyan He, Gang Zhai, Shouqi Xie, Jingou Tong, Jianfang Gui, Zhan Yin
Summary: The study found that a set of polymorphisms at the corticotropin releasing hormone receptor 2 (crhr2) locus is associated with improved fish feed conversion efficiency (FCE) in farmed allogynogenetic gibel carp strain CAS III. These polymorphisms downregulate crhr2 expression levels, compromising the HPI axis signaling and enhancing metabolism in CAS III. These findings suggest that genetic markers like crhr2 could be potentially useful for genetic selection to improve farmed fish growth and FCE, reducing fishmeal consumption and promoting sustainable fisheries.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)