Journal
GENE THERAPY
Volume 19, Issue 5, Pages 543-549Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2011.132
Keywords
cancer gene therapy; virotherapy; initial conditions; heterogeneity; mathematical modeling; nonlinear least square fitting
Categories
Funding
- Minnesota Partnership for Biotechnology and Medical Genomics
- [R01 CA130878]
- [R01 CA107082]
Ask authors/readers for more resources
Tumor selective, replication competent viruses are being tested for cancer gene therapy. This approach introduces a new therapeutic paradigm due to potential replication of the therapeutic agent and induction of a tumor-specific immune response. However, the experimental outcomes are quite variable, even when studies utilize highly inbred strains of mice and the same cell line and virus. Recognizing that virotherapy is an exercise in population dynamics, we utilize mathematical modeling to understand the variable outcomes observed when B16ova malignant melanoma tumors are treated with vesicular stomatitis virus in syngeneic, fully immunocompetent mice. We show how variability in the initial tumor size and the actual amount of virus delivered to the tumor have critical roles on the outcome of therapy. Virotherapy works best when tumors are small, and a robust innate immune response can lead to superior tumor control. Strategies that reduce tumor burden without suppressing the immune response and methods that maximize the amount of virus delivered to the tumor should optimize tumor control in this model system. Gene Therapy (2012) 19, 543-549; doi:10.1038/gt.2011.132; published online 15 September 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available