Pivotal role of leptin-hypothalamus signaling in the etiology of diabetes uncovered by gene therapy: a new therapeutic intervention?

Leptin Deficiency

(2016) Susan Blüher et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The Long and Winding Road to Understanding and Conquering Type 1 Diabetes

(2010) Pere Santamaria   IMMUNITY

Strategies to prevent the type 2 diabetes mellitus epidemic

(2010) R. Paul Robertson et al.   Nature Reviews Endocrinology

Treatment of type 2 diabetes mellitus with bariatric surgery

(2010) Peter Clifton   Nature Reviews Endocrinology

Leveraging leptin for type I diabetes?

(2010) D. Kraus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin: a pivotal regulator of human energy homeostasis

(2009) I Sadaf Farooqi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Leptin at 14 y of age: an ongoing story

(2009) Jeffrey M Friedman   AMERICAN JOURNAL OF CLINICAL NUTRITION

Leptin transport in the central nervous system

(2009) Yusuf Ziya Ziylan et al.   CELL BIOCHEMISTRY AND FUNCTION

Feeding signals and brain circuitry

(2009) Marcelo O. Dietrich et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Effects of Recombinant Human Leptin on Visceral Fat, Dyslipidemia, and Insulin Resistance in Patients with Human Immunodeficiency Virus-Associated Lipoatrophy and Hypoleptinemia

(2009) Kathleen Mulligan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation

(2009) Satya P. Kalra   PEPTIDES

Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice

(2009) Shinya Kojima et al.   PEPTIDES

Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay

(2009) Satya P. Kalra et al.   PEPTIDES

Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

(2008) Gilberto Paz-Filho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis

(2008) Ashwani Malhotra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans

(2008) Aoife M Brennan et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging

(2008) José M. Carrascosa et al.   EXPERIMENTAL GERONTOLOGY

Clinical gene therapy using recombinant adeno-associated virus vectors

(2008) C Mueller et al.   GENE THERAPY

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Disruption in the leptin–NPY link underlies the pandemic of diabetes and metabolic syndrome: New therapeutic approaches

(2008) Satya P. Kalra   NUTRITION

Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice

(2008) Michael G. Dube et al.   PEPTIDES

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DIABETES: Paradoxical Effects of Tightly Controlled Blood Sugar

(2008) G. Taubes   SCIENCE

Type 1 Diabetes Associated with Acquired Generalized Lipodystrophy and Insulin Resistance: The Effect of Long-Term Leptin Therapy

(2007) Jean Y. Park et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Central leptin insufficiency syndrome: An interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions

(2007) Satya P. Kalra   PEPTIDES