Article
Biophysics
David P. Rosen, Douglas A. Husmann, Lance A. Mynderse, Troy F. Kelly, Azra Alizad, Mostafa Fatemi
Summary: This study investigated the feasibility of using ultrasound bladder vibrometry (UBV) for detecting detrusor overactivity (DO) and developed a processing approach to identify transient peaks in data series. By applying a DO index as a classifier, sensitivities and specificities of 0.70 and 0.75 were achieved for detecting DO using UBV measurements. The results show promising potential for noninvasive detection of DO with further refinement of the UBV measurement process.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Obstetrics & Gynecology
Matteo Frigerio, Marta Barba, Alice Cola, Federico Spelzini, Rodolfo Milani, Stefano Manodoro
Summary: This study aimed to evaluate the relationship between COUB and POP surgery, and to identify possible risk factors for postoperative COUB. The results showed that patients with more severe anterior compartment prolapse and more frequent overactive bladder were more likely to have COUB preoperatively. However, COUB symptoms decreased significantly after POP repair. In addition, preoperative opening detrusor pressure was identified as the only independent predictor for postoperative COUB.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Virology
Bangxing Hong, Upasana Sahu, Matthew P. Mullarkey, Balveen Kaur
Summary: Oncolytic herpes simplex virus (oHSV) shows promise as a treatment for solid tumors, but there are still barriers that limit its efficacy. This review focuses on the essential viral genes that allow for virus replication and spread, with the aim of enhancing oHSV infection and replication among tumor cells.
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Medicine, Research & Experimental
Catielen Paula Pavi, Isabella Dai Pra, Rafael Dorighello Cadamuro, Isamu Kanzaki, Jhuly Wellen Ferreira Lacerda, Louis Pergaud Sandjo, Roberto Messias Bezerra, Jorge Federico Orellana Segovia, Gislaine Fongaro, Izabella Thais Silva
Summary: This study evaluated the activity of seventeen extracts derived from eight Amazonian medicinal plants against herpes simplex virus and chikungunya virus. Four extracts exhibited significant activity against both viruses, including the drug-resistant strains. Virucidal tests showed a higher level of virucidal activity compared to antiviral activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Virology
Mashidur Rana, Mizumi Setia, Pratima K. Suvas, Anish Chakraborty, Susmit Suvas
Summary: Reactive oxygen species (ROS) play a crucial role in herpes stromal keratitis (HSK), with neutrophils being the primary cells responsible for ROS generation. NOX2 is involved in ROS production in neutrophils. However, manipulating ROS levels in neutrophils may help alleviate the severity of HSK, and NOX2 is not the main contributor to ROS generation in neutrophils.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Ping-Hsuan Yu, Chih-Chieh Lin, Yu-Hua Fan, Alex T. L. Lin, William J. S. Huang
Summary: The study revealed that the bladder wall thickness was significantly greater in DO-DU patients compared to DU patients. There was a high correlation between the thicker bladder walls in DO-DU patients and urgency incontinence on the UDI-6 questionnaire, while no correlations existed between the bladder wall thickness of DU patients and any of the questionnaire data.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Victor Nitti, Cornelia Haag-Molkenteller, Michael Kennelly, Michael Chancellor, Brenda Jenkins, Brigitte Schurch
Summary: Neurogenic detrusor overactivity (NDO) is a complication of various conditions, such as multiple sclerosis and spinal cord injury, which leads to high bladder pressure and urinary incontinence. OnabotulinumtoxinA has been proven to be an effective treatment option for both NDO and non-neurogenic overactive bladder (OAB), significantly improving quality of life in patients. Clinical trials have shown positive results in terms of reduced incontinence episodes, improved urodynamic parameters, and better quality of life for patients with NDO and OAB.
Article
Immunology
Mette Ratzer Freytag, Sofie Eg Jorgensen, Michelle Molgaard Thomsen, Ali Al-Mousawi, Alon Schneider Hait, David Olagnier, Jakob T. Bay, Marie Helleberg, Trine H. Mogensen
Summary: This study describes a 19-year-old woman with systemic HSV-1 infection and HLH, as well as a fatal course of neonatal herpesvirus infection postpartum. Investigation showed impaired antiviral responses in the mother's cells, potentially caused by variants in CASP8 or other noncoding regions of the genome.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md. Asad Ullah, Yusha Araf, Sowmen Das, Md. Hasanur Rahman, Abu Tayab Moin
Summary: HSV is a highly infectious virus with two types, HSV-1 and HSV-2, infecting millions worldwide. This study designed three polyvalent subunit vaccines targeting multiple strains of HSV, which showed stability and potential effectiveness through molecular docking and simulation studies. Validation of these vaccines in wet lab-based studies is still needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Multidisciplinary
Pradeep Chopra, Tejabhiram Yadavalli, Francesco Palmieri, Seino A. K. Jongkees, Luca Unione, Deepak Shukla, Geert-Jan Boons
Summary: Inhibition of human heparanase (Hpse) has been found to be a promising therapeutic strategy for preventing the spread of herpes simplex virus (HSV-1). The synthesis of hexa- and octasaccharide inhibitors of Hpse showed potent enzyme inhibition and the presence of 2-O-sulfation on iduronic acid was tolerated. These inhibitors not only blocked viral-induced shedding of cell-surface heparan sulfate (HS) but also inhibited cell migration and proliferation in corneal epithelial cells infected with HSV-1.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
S. Takai, T. Majima, B. Reinhart, W. F. Goins, Y. Funahashi, M. Gotoh, P. Tyagi, J. C. Glorioso, N. Yoshimura
Article
Oncology
Hiroshi Nakashima, Tran Nguyen, Kazue Kasai, Carmela Passaro, Hirotaka Ito, William F. Goins, Imran Shaikh, Ronald Erdelyi, Reiko Nishihara, Ichiro Nakano, David A. Reardon, Ana C. Anderson, Vijay Kuchroo, E. Antonio Chiocca
CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Carmela Passaro, Quazim Alayo, Isabella De laura, John McNulty, Korneel Grauwet, Hirotaka Ito, Vivek Bhaskaran, Marco Mineo, Sean E. Lawler, Khalid Shah, Maria C. Speranza, William Goins, Eric McLaughlin, Soledad Fernandez, David A. Reardon, Gordon J. Freeman, E. Antonio Chiocca, Hiroshi Nakashima
CLINICAL CANCER RESEARCH
(2019)
Article
Urology & Nephrology
Tsuyoshi Majima, Kenichi Mori, Ka Tsumi Kadekawa, Shun Takai, Yasuhito Funahashi, Bonnie Reinhart, William F. Coins, Momokazu Gotoh, Joseph C. Glorioso, Naoki Yoshimura
NEUROUROLOGY AND URODYNAMICS
(2019)
Correction
Oncology
Carmela Passaro, Quazim Alayo, Isabel DeLaura, John McNulty, Korneel Grauwet, Hirotaka Ito, Vivek Bhaskaran, Marco Mineo, Sean E. Lawler, Khalid Shah, Maria C. Speranza, William Goins, Eric McLaughlin, Soledad Fernandez, David A. Reardon, Gordon J. Freeman, E. Antonio Chiocca, Hiroshi Nakashima
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Paola Sette, Nduka Amankulor, Aofei Li, Marco Marzulli, Daniela Leronni, Mingdi Zhang, William F. Goins, Balveen Kaur, Chelsea Bolyard, Timothy P. Cripe, Jianhua Yu, E. Antonio Chiocca, Joseph C. Glorioso, Paola Grandi
MOLECULAR THERAPY-ONCOLYTICS
(2019)
Article
Multidisciplinary Sciences
Quazim A. Alayo, Hirotaka Ito, Carmela Passaro, Mykola Zdioruk, Ahmad Bakur Mahmoud, Korneel Grauwet, Xiaoli Zhang, Sean E. Lawler, David A. Reardon, William F. Goins, Soledad Fernandez, E. Antonio Chiocca, Hiroshi Nakashima
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Seiji Kuroda, Yoshitaka Miyagawa, Yuriko Sato, Motoko Yamamoto, Kumi Adachi, Hiromi Kinoh, William F. Goins, Justus B. Cohen, Joseph C. Glorioso, Nobuhiko Taniai, Hiroshi Yoshida, Takashi Okada
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Article
Biochemistry & Molecular Biology
Bonnie L. Hall, Daniela Leronni, Yoshitaka Miyagawa, William F. Goins, Joseph C. Glorioso, Justus B. Cohen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Microbiology
Benjamin E. Warner, Michael B. Yee, Mingdi Zhang, Rebecca S. Hornung, Benedikt B. Kaufer, Robert J. Visalli, Phillip R. Kramer, William F. Goins, Paul R. Kinchington
Summary: Studies using a rat model of VZV inoculation show that viral gene expression is necessary for the development of pain behaviors.
Article
Biology
Frederick Robert Carrick, Sergio F. Azzolino, Melissa Hunfalvay, Guido Pagnacco, Elena Oggero, Ryan C. N. D'Arcy, Mahera Abdulrahman, Kiminobu Sugaya
Summary: The pupillary light reflex (PLR) is modulated by cognitive brain function and can be affected by long-term changes in brain function due to injury. PLR variables such as latency, pupil diameter, constriction velocity, and recovery time show significant differences between subjects with and without concussion history, as well as differences related to gender and symptoms. These differences suggest that PLR metrics can serve as biomarkers for clinical diagnosis and decision making in individuals with concussive injuries.
Article
Biology
Ruben Berrocal Timmons, Kiminobu Sugaya, Lori Deneke Bane
Summary: Injecting cryopreserved umbilical cord tissue (UCT) can alleviate knee pain, improve physical function, and reduce medication use in knee pain subjects.
Article
Biochemistry & Molecular Biology
Manjusha Vaidya, Sandeep Sreerama, Maxine Gonzalez-Vega, Jonhoi Smith, Melvin Field, Kiminobu Sugaya
Summary: Glioblastoma multiforme (GBM) possesses cancer stem cells (CSCs) that contribute to its invasiveness, recurrence, and metastasis. The transcriptional profiles of the cancer cells change when cocultured with neural stem cells (NSCs), resulting in upregulation of stemness and drug resistance genes in GBM and triggering NSCs differentiation. Cell-secreted signaling molecules and extracellular vesicles (EVs) are likely involved in the reciprocal communication and transcription modification between GBM and NSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Frederick Robert Carrick, Luis Sebastian Alexis Valerio, Maxine N. Gonzalez-Vega, David Engel, Kiminobu Sugaya
Summary: Wounds can have a severe impact on the wellbeing of individuals and society, and technology that accelerates wound healing can bring many benefits to injured people. In a study using a ceramic far-field infrared blanket, it was found that wound healing in mice was significantly faster, and mesenchymal stem cells also showed increased wound-healing effects in this environment.
Review
Biochemistry & Molecular Biology
Joseph C. Glorioso, Justus B. Cohen, William F. Goins, Bonnie Hall, Joseph W. Jackson, Gary Kohanbash, Nduka Amankulor, Balveen Kaur, Michael A. Caligiuri, E. Antonio Chiocca, Eric C. Holland, Christophe Queva
Summary: The therapeutic potential of oncolytic viruses lies in their ability to selectively kill tumor cells and stimulate anti-tumor immunity. Oncolytic herpes simplex viruses (oHSVs) are among the most studied OVs for treating solid malignancies, with Amgen's oHSV Imlygic (R) being the only approved OV in major markets.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)