Journal
GENE THERAPY
Volume 15, Issue 10, Pages 759-764Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2008.43
Keywords
erythropoietin; cancer; regulation; dimerizer
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Many recombinant growth factors have failed in clinical trials due to off-target effects. We describe a method for circumventing off-target effects that involves equipping cells with a conditionally active signaling protein that can be specifically activated by an exogenously administered synthetic ligand. We believe that this approach will have many applications in gene and cell therapy.
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