Article
Dermatology
Burak Aksan, Aysegul Basak Akadam-Teker
Summary: The TT genotype and T allele of IL-17A rs10484879 are associated with an increased risk of psoriasis in the Turkish population. This study suggests that IL-17A polymorphism may play a role in the pathogenesis of the disease. The IL-17A serum levels were also found to be associated with the genotype distribution.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Immunology
Dongsheng Liu, Jinyun Wang, Yong Xie
Summary: Refractory Helicobacter pylori infection leads to significant alterations in gastric microbiota, inhibiting the growth of beneficial Lactobacillus. Patients with refractory H. pylori infection may be more prone to developing gastric cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Bingting Yu, Luochengling Xiang, Maikel P. Peppelenbosch, Gwenny M. Fuhler
Summary: This study demonstrates that H. pylori infection and GC are linked to elevated levels of IL-6 and TNF-alpha. Notably, the increase in IL-6 is region-specific and correlates with GC incidence, suggesting its key role in the development of this disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Matheus Braga, Fernanda Formaggi Lara-Armi, Janisleya Silva Ferreira Neves, Marco Antonio Rocha-Loures, Mariana de Souza Terron-Monich, Larissa Danielle Bahls-Pinto, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Ana Maria Sell, Jeane Eliete Laguila Visentainer
Summary: The IL10 -1082 A>G (rs1800896) genotype is associated with AS, with AS patients having higher levels of IL-10 in serum, and the IL17F rs763780 polymorphism can affect the levels of IL-17F in the serum.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lorna C. Waters, Vaclav Veverka, Sarah L. Strong, Frederick W. Muskett, Neesha Dedi, Alastair D. G. Lawson, Christine E. Prosser, Richard J. Taylor, Alistair J. Henry, Mark D. Carr
Summary: IL-17A and IL-17F, as key proinflammatory cytokines, play crucial roles in human inflammatory diseases, forming dimers with striking conformational dynamic differences in binding to IL-17RA, which may contribute to their varying affinities.
Review
Rheumatology
Nataliya Yeremenko
Summary: IL-17 family cytokines may act as agonists or antagonists to IL-17A contributing in concert to local inflammatory responses. Understanding their function, identifying their cellular sources, and elucidating the molecular mechanisms driving their expression will be crucial in designing rational therapies for SpA.
CURRENT OPINION IN RHEUMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yang Wu, Zhiyong Song, Guiyun Deng, Kai Jiang, Huajuan Wang, Xueji Zhang, Heyou Han
Summary: The study uses nanomotors loaded with drugs to combat gastric cancer caused by Helicobacter pylori infection, successfully achieving rapid neutralization of gastric acid and drug release in animal models to achieve good therapeutic effects.
Review
Health Care Sciences & Services
Vyshnavy Balendra, Chiara Amoroso, Barbara Galassi, Josephine Esposto, Claudia Bareggi, Jennie Luu, Lucia Scaramella, Michele Ghidini
Summary: High-salt diet and H. pylori infection are important factors contributing to gastric cancer development, with their combined impact increasing the risk of gastric adenocarcinoma. Mechanisms such as disruption of mucosal barriers and induction of inflammatory responses play a role in the development of gastric cancer. Therefore, reducing salt intake and using antibacterial therapy may potentially lower the susceptibility to gastric cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Jee Hyun Kang, Suyoung Park, Jinhyung Rho, Eun-Ju Hong, Young-Eun Cho, Young-Suk Won, Hyo-Jung Kwon
Summary: IL-17A promotes gastric carcinogenesis, potentially through the regulation of the IL-17RC/NF-κB/NOX1 pathway. This finding provides a new target for the treatment of gastric cancer.
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Microbiology
Marina A. Senchukova
Summary: H. pylori plays a role in the development of gastric cancer through interactions with pattern-recognition receptors on immune and epithelial cells. In addition to induction, H. pylori may also affect the mechanisms of gastric cancer progression.
CURRENT MICROBIOLOGY
(2022)
Article
Oncology
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Hyun Ja Kim
Summary: This study found an association between specific RAD50 gene polymorphisms and increased risk of gastric cancer case-fatality, especially in individuals with high sodium intake or positive H. pylori infection.
Article
Nutrition & Dietetics
Han-Na Kim, Min-Jeong Kim, Jonathan. P. P. Jacobs, Hyo-Joon Yang
Summary: This study investigated the microbial changes and host inflammatory cytokine responses in H. pylori-negative gastric cancer patients. The results showed that the gastric mucosal microbiota in GC patients had reduced diversity and a different composition compared to controls. Lacticaseibacillus was enriched, while Haemophilus and Campylobacter were depleted in the cancer group. Furthermore, the combined abundance of these taxa correlated significantly with gastric mucosal IL1B expression.
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Xinyuan Liu, Xinyu Wang, Tao Mao, Xiaoyan Yin, Zhi Wei, Jindong Fu, Jie Wu, Xiaoyu Li
Summary: This study aimed to summarize the characteristics of early gastric cancer (EGC) after Helicobacter pylori (H. pylori) eradication. The results showed that EGC after H. pylori eradication is characterized by long-term proton pump inhibitor (PPI) use, moderate mucosal atrophy, mucosal map-like redness, mild activity of gastric mucosa, a higher proportion of high-grade intraepithelial neoplasia (HGIN) cases, and lower levels of Ki-67. H. pylori-positive patients at OLGA stages I-II are also more likely to progress to EGC. According to the current data, different eradication intervals of H. pylori have little effect on the characteristics of EGC.
ANNALS OF MEDICINE
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.