Article
Physiology
Xiao Li, Jian-Wen Li, Wen-Xiu Sun, Wei Li, Hua-Yuan Gao, Tong-Xian Liu, Ming-Jing Qu
Summary: The study assembled the antennal transcriptomes of the great gray weevil and identified major chemosensory genes involved in olfaction. The expression analysis revealed that these genes play important roles in olfaction and some of them are regulated by antenna-enrichment and sex-biased expression. The study also investigated the binding property of an antenna-abundant odorant-binding protein, providing insights into the olfactory systems of the weevil species.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Entomology
Aneela Younas, Muhammad Irfan Waris, Muhammad Shaaban, Muhammad Tahir ul Qamar, Man-Qun Wang
Summary: The study revealed that MsepCSP14 shows significant expression and high binding affinity in female Mythimna separata. This chemosensory protein is likely to mediate chemosensory functions in M. separata.
Article
Engineering, Environmental
Fuxiang Yang, Guoqing Zhang, Jinlong Liu, Shuanggang Duan, Lei Li, Yongyue Lu, Man-Qun Wang, Aiming Zhou
Summary: Cadmium contamination affects the chemosensory function of ants by altering the expression patterns of odor binding protein genes, resulting in impaired olfactory signal transduction and chemosensory dysfunction.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yonghao Dong, Tong Li, Jin Liu, Meixue Sun, Xingyu Chen, Yongjie Liu, Pengjun Xu
Summary: OBPs and CSPs are important in initiating odor recognition in insects. In Spodoptera exempta, 40 OBPs and 33 CSPs were identified, with some showing higher expression in larvae or pupae. These proteins have gender-biased expression patterns in adult antennae, but highly expressed ones in adults are either male-biased or neutral in whole-body expression.
Article
Entomology
Yijiangcheng Li, Hongchao Chen, Xinhao Liang, Shanshan Wang, Hanqi Zhu, Mengwen Yan, Fuan Wu, Jun Wang, Sheng Sheng
Summary: This study obtained the antennal transcriptome dataset of Iseropus kuwanae, an ectoparasitoid wasp attacking the larvae of a moth species harmful to mulberry trees in China, and identified a total of 122 candidate chemosensory genes. These findings lay the foundation for further exploration of chemosensory mechanisms in this parasitoid wasp.
JOURNAL OF APPLIED ENTOMOLOGY
(2022)
Article
Physiology
Xiaoyu Zhang, Zhende Yang, Xiuhao Yang, Hongxuan Ma, Xiumei Liu, Ping Hu
Summary: Endoclita signifier, a new wood-boring pest in Eucalyptus plantations in southern China since 2007, demonstrates native insect adaptation to an exotic host. Research on its olfactory proteins suggests the importance of the larval olfactory system in host selection.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ning-Na Yin, Yu-Juan Yao, Yin-Lan Liang, Zheng-Quan Wang, Yong-He Li, Nai-Yong Liu
Summary: The study characterizes the chemosensory protein (CSP) gene family in the oligophagous cone-feeding moth Dioryctria abietella. It reveals the different odor binding spectra of four antennae-enriched DabiCSPs, and identifies key residues responsible for the binding of DabiCSP1 and potentially active compounds for the control of this pest.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Entomology
Qian Jia, Hui Zeng, Jinbing Zhang, Shangfang Gao, Nan Xiao, Jing Tang, Xiaolin Dong, Wei Xie
Summary: Insects can accurately respond to environmental chemical signals through chemosensory proteins (CSPs). The crystal structure of CSP8 protein from the tobacco cutworm was studied, providing insights into the molecular recognition mechanism of SlCSP8 and the CSP protein family. The research suggests that CSP8 is crucial for insects to identify certain compounds, which may have implications for future CSP-based drug design.
Article
Agriculture, Multidisciplinary
Wang Ke, He Yan-yan, Zhang You-jun, Guo Zhao-jiang, Xie Wen, Wu Qing-jun, Wang Shao-li
Summary: This study investigated the role of EforCSP3 in olfaction, specifically in host location and preference in the parasitoid wasp Encarsia formosa. It was found that EforCSP3 was highly expressed in the female head and showed a higher expression in adults than in other developmental stages. EforCSP3 exhibited a high binding affinity to a wide range of host-related volatiles, suggesting its involvement in semiochemical reception. The results also predicted the amino acid residues of EforCSP3 that may be involved in volatile binding.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Agriculture, Multidisciplinary
Omar Al-Danoon, Suman Mazumder, Bharat P. Chaudhary, Viswanath Nukala, Benton Bishop, Gage Cahoon, Smita Mohanty
Summary: The lepidopteran moth Ostrinia nubilalis plays a significant role in impacting crop production in the US and Europe. The Pheromone binding proteins (PBPs) in male moth antennae are crucial in detecting and delivering pheromones for mating. The study on Ostrinia nubilalis PBP3 (OnubPBP3) revealed nanomolar affinity to pheromones, pH-induced unfolding behavior, and ligand-induced conformational changes, suggesting stability differences when bound to E- versus Z-isomers of the pheromone.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yinhui Kuang, Chaozhi Shangguan, Sichen Yuan, Qiaoqin Zhang, Ziying Qiu, Liwei Gao, Xiudao Yu
Summary: The study identified and analyzed OBP/CSP genes in L. erysimi, finding 11 LeryOBP and 4 LeryCSP transcripts. Expression analysis showed elevated expression of 5 LeryOBP genes and LeryCSP10 in the antennae, suggesting their potential role in perceiving new host plant locations.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Entomology
Aniruddha Agnihotri, Naiyong Liu, Wei Xu
Summary: Chemosensory proteins (CSPs) are small, soluble proteins that play a crucial role in transporting odorant and pheromone molecules in the insect chemosensory system. Recent studies reveal that they also function in development, nutrient metabolism and insecticide resistance. In this study, 27 CSP genes were identified from the genome and transcriptome sequences of cotton bollworm, Helicoverpa armigera (Hubner). The expression patterns of these genes were studied by using transcriptomic data obtained from different tissues and stages. The results demonstrate that H. armigera CSP genes are not only highly expressed in chemosensory tissues, such as antennae, mouthparts, and tarsi, but also in the salivary glands, cuticle epidermis, and hind gut. A new method was developed that significantly increased the expression levels of two selected CSPs as soluble recombinant proteins for purification. This study advances our understanding of insect CSPs and provides a new approach to highly express recombinant CSPs in E. coli.
Article
Biochemistry & Molecular Biology
Yu-Xiao Si, Jin-Meng Guo, Hui Liao, Yu Li, Yu Ma, Yu-Wei Zhu, Zhi-Qiang Wei, Shuang-Lin Dong, Qi Yan
Summary: This study demonstrates for the first time the differential recognition of sex pheromone components by three pheromone-binding proteins (PBPs) in a moth using mixed-type sex pheromones. The PBPs in Orthaga achatina showed highly male-biased expression in antennae and different binding affinities to different sex pheromone components. Key amino acid residues involved in the binding of sex pheromone components were also identified in the PBPs.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Entomology
Zhenchen Wu, Jia Ye, Jiali Qian, Endang Rinawati Purba, Qinghe Zhang, Longwa Zhang, Dingze Mang
Summary: Chemosensory receptor genes play an important role in insect chemodetection, but the understanding of these genes in Coleoptera is limited. In this study, the chemosensory receptor genes of the red-necked longicorn beetle were analyzed, and their functions in pheromone sensing and taste perception were identified.
Article
Physiology
Zehua Wang, Fan Yang, Ang Sun, Shuang Shan, Yongjun Zhang, Shanning Wang
Summary: Chemosensory protein HhalCSP15 was found to be enriched in the antennae of Halyomorpha halys, suggesting its involvement in olfactory perception. Three natural compounds showed strong binding abilities with HhalCSP15, with EEZ-MDT acting as a kairomone during host plant foraging in H. halys. These findings provide insight into the physiological roles of CSPs in H. halys and expand the understanding of CSPs' olfactory function in stink bugs.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.