Article
Medicine, Research & Experimental
Yingming Jiang, Yanchun Feng, Jintuan Huang, Zhenze Huang, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Jun Qiu, Chujun Li, Hao Chen, Zuli Yang
Summary: This study found that LAD1 is overexpressed in gastric cancer tissues and is associated with poorer disease-free survival and overall survival in patients. Functional experiments demonstrated that LAD1 plays a positive role in promoting invasion, migration, proliferation, and chemoresistance of gastric cancer cells. Mechanistically, LAD1 competitively binds to Vimentin, preventing its interaction with the E3 ubiquitin ligase MAEA, thereby reducing K48-linked ubiquitination of Vimentin and increasing its protein levels in gastric cancer cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yang-Hsiang Lin, Siew-Na Lim, Cheng-Yi Chen, Hsiang-Cheng Chi, Chau-Ting Yeh, Wey-Ran Lin
Summary: Mitochondrial DNA plays a significant role as a genetic biomarker in disease, cancer, and evolution. It functions as a modulator for regulating cellular metabolism and its variations and dysregulation are associated with cancer patient survival outcomes. Additionally, nuclear-encoded genes regulate mitochondrial homeostasis by controlling the expression of mitochondria-encoded genes. The crosstalk between nuclear and mitochondrial genomes is crucial for cellular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yan Pu, Xu Wen, Zhangjun Jia, Yu Xie, Changxing Luan, Youjia Yu, Feng Chen, Peng Chen, Ding Li, Yan Sun, Jian Zhao, Haiqin Lv
Summary: Gastric cancer ranks second in incidence among all malignancies in China, posing a significant threat to human health. This study identified a significant association between the EFNA1 rs4971066 polymorphism and reduced susceptibility to gastric cancer development through the analysis of tagSNPs in GC related genes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Zhandong Zhang, Liangqun Peng, Wei Yang, Baodong Li, Yawei Hua, Suxia Luo
Summary: This study aimed to investigate the role of PHF5A in the progression of gastric cancer (GC) and its potential mechanism of action. Immunohistochemical staining experiments showed that PHF5A was abundantly expressed in GC and was associated with poor prognosis. Knockdown of PHF5A in GC cells inhibited proliferation, enhanced sensitivity to apoptosis, and decreased migration. Mechanistically, decreased PHF5A led to decreased protein stability of FOS through SKP2-mediated ubiquitination. Inhibition of PHF5A reversed the induction of malignant phenotypes and tumor formation in GC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Cong Zhang, Huixia Wang, Qingwei Liu, Suli Dai, Guo Tian, Xintong Wei, Xiaoya Li, Lianmei Zhao, Baoen Shan
Summary: In this study, it was found that the expression of CCAT1 was significantly increased in the tissues and plasma exosomes of GC patients, as well as GC cell lines. Functional experiments showed that the knockdown of CCAT1 resulted in a substantial decrease in the proliferation, migration, and invasion of GC cells through decreasing the expression of glycolytic enzymes and glycolytic rate. Conversely, overexpression of CCAT1 exhibited contrasting effects.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Nasha Zhang, Bowen Wang, Chi Ma, Jiajia Zeng, Teng Wang, Linyu Han, Ming Yang
Summary: In this study, a new long non-coding RNA (lncRNA), LINC00240, was discovered to be transcribed from the 6p22.1 gastric cancer risk locus and function as an oncogene. LINC00240 was found to be highly expressed in gastric cancer specimens and associated with poor patient survival. Additionally, LINC00240 was shown to promote malignant proliferation, migration, and metastasis of gastric cancer cells. Importantly, LINC00240 stabilized the oncoprotein DDX21 by enhancing its interaction with its novel deubiquitinating enzyme USP10, thereby promoting gastric cancer progression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Jianping Zou, Ling Zhou, Yi Le, Zhi Fang, Min Zhong, Fengting Nie, Xianpin Wei, Xiaomei Zhang, Zhen Chen, Lingling Cai, Heng Wang, Jianping Xiong, Ziling Fang, Xiaojun Xiang
Summary: In this study, the functional role of the WWP2-LATS1 axis in gastric cancer cells was investigated. The axis was found to promote the proliferation and invasion of gastric cancer cells by regulating the Hippo-YAP1 signaling pathway. WWP2 interacts with LATS1, leading to its degradation and increased transcriptional activity of YAP1. This research provides important insights into the molecular mechanisms underlying gastric cancer development and progression.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Lifeng Feng, Muchun Li, Xinyang Hu, Yiling Li, Liyuan Zhu, Miaoqin Chen, Qi Wei, Wenxia Xu, Qiyin Zhou, Weikai Wang, Dingwei Chen, Xian Wang, Hongchuan Jin
Summary: Chemoresistance, previously seen as a stable outcome resulting from genetic changes, can also be unstable and reversible due to non-genetic alterations. The downregulation of ATF4 protein expression is associated with chemoresistance in gastric cancer cells, and its stabilization through inhibition of degradation can overcome resistance. ATF4 expression plays a crucial role in dynamic drug resistance, and interventions targeting its degradation pathway show promise in overcoming chemoresistance.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Qianqian Xu, Guangzhao Pan, Zhonglan Wang, Lingling Wang, Yancheng Tang, Jinyun Dong, Jiang-Jiang Qin
Summary: In this study, it was found that Platycodin D (PD) can inhibit gastric cancer cell viability by destabilizing the c-Myc protein, leading to cell cycle arrest and subsequent apoptosis. This novel molecular mechanism proposes a potential anti-cancer therapy using PD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Keqiang Rao, Ke Zheng, Qin Zhao, Jing He, Bei Zhou, Guofang Hou, Nannan Sha, Wang Wang, Man Yan, Yue Zhou, Yuting Jin, Yuhui Jiang, Qiang Xia
Summary: The G1958A single nucleotide polymorphism (SNP) of the MTHFD1 gene was found to affect the stability of MTHFD1 protein in hepatocellular carcinoma (HCC), leading to altered tumor metabolism. This finding provides a molecular basis for considering MTHFD1 as a therapeutic target.
Review
Biochemistry & Molecular Biology
Lidia-Sabina Cosma, Sophie Schlosser, Hauke C. Tews, Martina Mueller, Arne Kandulski
Summary: This article presents an overview of the genetic characteristics and current treatment approaches of hereditary diffuse gastric cancer (HDGC). It highlights the importance of the CTNNA1 gene, among others, in relation to this disease, and emphasizes the need for risk management in diagnosing patients through genetic testing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Maria J. Lopez, Junior Carbajal, Alejandro L. Alfaro, Luis G. Saravia, Daniel Zanabria, Jhajaira M. Araujo, Lidia Quispe, Alejandra Zevallos, Jose L. Buleje, Cristina Eunbee Cho, Marisol Sarmiento, Joseph A. Pinto, Williams Fajardo
Summary: Gastric cancer is a significant global health issue, with the highest incidence in Eastern Asia and Eastern/Central Europe. Different regions show varying patterns of histological types and tumor locations. TP53, LRP1B, and ARID1A are frequently altered genes in all populations. Further research is needed in underrepresented regions like Latin America and Africa.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniel E. Platt, Hovig Artinian, Francis Mouzaya, Wissam Khalil, Francois G. Kamar, Elizabeth Matisoo-Smith, Francesc Calafell, Nassim Nicolas Taleb, Pierre Zalloua
Summary: There are 18 different religious communities living in Lebanon, showing genetic isolation and autosomal clustering. Analysis of Y-chromosome STR and SNP data reveals a Levantine branching around 5000 years ago and distinct genetic components in the North Lebanese Mountain Maronite community. The Levantine L1b group split from the Caucasus ancestral group around 7300 years ago, with cultural barriers marked by the transmission of L1b lineages.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Oncology
Huixin Hu, Jingjing Jing, Xiaodong Lu, Yuan Yuan, Chengzhong Xing
Summary: XPF expression is significantly up-regulated in CRC compared with non-tumor controls and adenoma tissue. XPF expression is related to tumor location and growth pattern, and low expression may be significantly associated with better overall survival in patients with stage T1-T2.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Kun Gao, Qing Shi, Yajuan Liu, Chenji Wang
Summary: This study reveals a negative regulatory role of SPOP in autophagy and NFE2L2 pathway activation. The study found that SPOP induces non-degradative ubiquitination of SQSTM1, thereby suppressing autophagy and NFE2L2 pathway activation. The PCa-associated SPOP mutants lose the capacity to ubiquitinate SQSTM1 and instead enhance autophagy and the antioxidant response in a dominant-negative manner.
Article
Gastroenterology & Hepatology
Yan Cui, Shao-Bo Li, Xing-Chun Peng, Jun Wu, Guo-Hui Fu
DIGESTIVE DISEASES AND SCIENCES
(2015)
Article
Oncology
Ting Wang, Hong-Jun Fei, Ye Yang, Xiao-Shu Jiang, Min Yan, Zhi Zeng, Jun Wu, Ling-Jun Song, Hua Tian, Guo-Hui Fu
Article
Oncology
Li-Dong Zu, Xing-Chun Peng, Zhi Zeng, Jing-Long Wang, Li-Li Meng, Wei-Wei Shen, Chun-Ting Hu, Ye Yang, Guo-Hui Fu
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Xing-Chun Peng, Zhi Zeng, Yu-Ning Huang, Yun-Chao Deng, Guo-Hui Fu
Article
Pharmacology & Pharmacy
Wen-Hao Suo, Ning Zhang, Ping-Ping Wu, Lei Zhao, Ling-Jun Song, Wei-Wei Shen, Lin Zheng, Jing Tao, Xi-Dai Long, Guo-Hui Fu
BRITISH JOURNAL OF PHARMACOLOGY
(2012)
Article
Oncology
Lei Zhao, Xi-Dai Long, Jin-Guang Yao, Chao Wang, Yun Ma, Yong-Zhi Huang, Yun-Qian Li, Min-Fa Wang, Guo-Hui Fu
CANCER EPIDEMIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Ting Wang, Lei Zhao, Ye Yang, Hua Tian, Wen-Hao Suo, Min Yan, Guo-Hui Fu
Article
Genetics & Heredity
Ling-Jun Song, Rui-Jun Liu, Zhi Zeng, Seth L. Alper, Heng-Jing Cui, Yang Lu, Lin Zheng, Zhao-Wen Yan, Guo-Hui Fu
JOURNAL OF MOLECULAR MEDICINE-JMM
(2012)
Article
Oncology
Zhi Zeng, Hong-Xue Wu, Na Zhan, Ya-Bing Huang, Ze-Sheng Wang, Gui-Fang Yang, Ping Wang, Guo-Hui Fu
Article
Oncology
Ya Cao, Jinglong Wang, Hua Tian, Guo-Hui Fu
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Computer Science, Artificial Intelligence
Hong Yu, Xiaofan Zhang, Lingjun Song, Liren Jiang, Xiaodi Huang, Wen Chen, Chenbin Zhang, Jiahui Li, Jiji Yang, Zhiqiang Hu, Qi Duan, Wanyuan Chen, Xianglei He, Jinshuang Fan, Weihai Jiang, Li Zhang, Chengmin Qiu, Minmin Gu, Weiwei Sun, Yangqiong Zhang, Guangyin Peng, Weiwei Shen, Guohui Fu
Summary: The research team collected a large-scale whole-slide image dataset and designed a whole-slide image analyzing framework, achieving high sensitivity and specificity in screening and segmentation tasks, providing reference for pathologists in identifying suspicious areas.
Article
Oncology
Yi Yu, Jing-Long Wang, Li-Li Meng, Chun-Ting Hu, Zhao-Wen Yan, Zhi-Ping He, Xiao-Qin Shi, Guo-Hui Fu, Li-Dong Zu
Summary: Colorectal cancer is one of the most malignant cancers, with DDX54 being found to be overexpressed in CRC tissues and correlated with tumor stage and distant metastasis, promoting tumorigenesis by enhancing CRC cell proliferation and migration through increasing p65 and AKT phosphorylation levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Ping Wang, Juan Mei, Jing Tao, Ning Zhang, Hua Tian, Guo-Hui Fu
HISTOLOGY AND HISTOPATHOLOGY
(2012)
Article
Gastroenterology & Hepatology
Ping Wang, Juan Mei, Ning Zhang, Jing Tao, Hua Tian, Guo-Hui Fu
HEPATO-GASTROENTEROLOGY
(2011)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.