Article
Medicine, General & Internal
Yildiz Hayran, Nuran Alli, Umit Akpinar, Ayse Oktem, Cigdem Yucel, Esra Firat Oguz, Turan Turhan
Summary: Elevated serum galectin-3 levels in psoriasis patients may indicate a possible role of galectin-3 in the pathogenesis of psoriasis. A serum galectin-3 level >10 ng/mL may increase the risk of psoriasis by 14.5 times, but there is no significant correlation between serum galectin-3 level and disease characteristics or other inflammatory markers.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Oncology
Guillermo Herrador-Canete, Marta Zalacain, Sara Labiano, Virginia Laspidea, Montserrat Puigdelloses, Lucia Marrodan, Marc Garcia-Moure, Marisol Gonzalez-Huarriz, Javier Marco-Sanz, Iker Ausejo-Mauleon, Daniel de la Nava, Reyes Hernandez-Osuna, Javier Martinez-Garcia, Noelia Silva-Pilipich, Elisabeth Gurucega, Ana Patino-Garcia, Ruben Hernandez-Alcoceba, Cristian Smerdou, Marta M. Alonso
Summary: The usage of Semliki Forest virus (SFV) vectors expressing galectin-3 inhibitors as therapeutic tools showed promising results in reducing tumor progression and improving immune responses in pediatric osteosarcoma patients.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Pathology
Lauren N. Alfino, Kai C. Wilczewski-Shirai, Kathryn E. Cronise, Jonathan Coy, Kristina Glapa, E. J. Ehrhart, Joseph B. Charles, Dawn L. Duval, Daniel P. Regan
Summary: Periostin is an important matricellular protein involved in regulating bone, tooth, and cardiac development, but also plays a role in inflammatory diseases and certain cancers. In this study, periostin expression was found to be significantly upregulated in canine osteosarcoma tumors, but not associated with time to metastasis. Tumors with high periostin expression showed activation of pro-tumorigenic pathways, while tumors with low periostin expression showed enhanced anti-tumor immune responses.
VETERINARY PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Diyoly Ayona, Sandra Madariaga Zarza, Ludovic Landemarre, Benoit Roubinet, Philippe Decloquement, Didier Raoult, Pierre-Edouard Fournier, Benoit Desnues
Summary: Tropheryma whipplei is an actinobacterium that causes various infections in humans, including Whipple's disease. The bacterium's complex surface glycoproteins contain different sugars, and they interact with Galectin-1 and Galectin-3 to promote infection.
Article
Biochemistry & Molecular Biology
Beata Kusnierz-Cabala, Barbara Maziarz, Paulina Dumnicka, Marcin Dembinski, Maria Kapusta, Monika Bociasa-Jasik, Marek Winiarski, Aleksander Garlicki, Tomasz Grodzicki, Michal Kukla
Summary: This preliminary study found that serum galectin-3 levels were significantly increased in COVID-19 patients who developed pneumonia and required intensive care unit (ICU) treatment. Serum galectin-3 showed moderate diagnostic accuracy for diagnosing pneumonia and high diagnostic accuracy for predicting the need for ICU treatment. Further studies are needed to confirm these findings and explore the potential role of galectin-3 in severe COVID-19 cases.
Article
Allergy
Martina Konantz, Margaret Williams, Tamara Merkel, Antonia Reiss, Stefan Dirnhofer, Sara C. Meyer, Peter Valent, Tracy I. George, Alexandar Tzankov, Karin Hartmann
Summary: This study found that serum levels of TIM-3 and galectin-9 are increased in patients with advanced systemic mastocytosis. Additionally, TIM-3 and galectin-9 are expressed in bone marrow infiltrates in mastocytosis. These findings suggest that TIM-3 and galectin-9 could be explored as diagnostic markers and potential therapeutic targets in systemic mastocytosis, particularly in advanced forms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han-Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu-Tong Liu, Nobuyuki Takakura
Summary: This study demonstrates that Gal-3 expression in long-term repopulating HSCs is induced in response to Tie2 and Mpl, and plays a crucial role in maintaining HSC quiescence through regulation of p21.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Zhendong Cheng, Kefeng Cai, Chaoxian Xu, Qiong Zhan, Xingbo Xu, Dingli Xu, Qingchun Zeng
Summary: This study evaluated the association between serum galectin-3 and all-cause death (ACD) and cardiovascular death (CVD) in patients with chronic heart failure (CHF). The results showed that higher serum galectin-3 levels were associated with an increased risk of ACD and CVD in CHF patients. Subgroup analysis revealed that the risk was higher in the shorter follow-up group. These findings suggest that serum galectin-3 may have prognostic value and could be useful for risk classification in CHF patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Shihan Zhen, Ruoxin Cai, Xuelian Yang, Yanan Ma, Deliang Wen
Summary: The study revealed a positive association between serum GAL-3BP levels and MetS, especially in postmenopausal women. Additionally, increased expression of GAL-3BP in the serum and visceral adipose tissue of high fat diet mice suggests its relevance to MetS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Brendan D. Curti, Yoshinobu Koguchi, Rom S. Leidner, Annah S. Rolig, Elizabeth R. Sturgill, Zhaoyu Sun, Yaping Wu, Venkatesh Rajamanickam, Brady Bernard, Ian Hilgart-Martiszus, Christopher B. Fountain, George Morris, Noriko Iwamoto, Takashi Shimada, ShuChing Chang, Peter G. Traber, Eliezer Zomer, J. Rex Horton, Harold Shlevin, William L. Redmond
Summary: Combination therapy of belapectin and pembrolizumab shows promising activity in patients with metastatic melanoma and head and neck squamous cell carcinoma, with increased activation of effector memory T cells and decreased levels of monocytic myeloid-derived suppressor cells observed in responders. Additionally, increased expression of Gal-3, PD-1+CD8+ T cells, and higher serum trough levels of pembrolizumab are correlated with treatment response, indicating potential biomarkers for clinical outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Madoka Koyanagi, Satoshi Imai, Mayuna Matsumoto, Yoko Iguma, Nobuko Kawaguchi-Sakita, Takeshi Kotake, Yuki Iwamitsu, Mpumelelo Ntogwa, Ren Hiraiwa, Kazuki Nagayasu, Mamiko Saigo, Takashi Ogihara, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Takayuki Nakagawa, Kazuo Matsubara
Summary: The elevated plasma galectin-3 level is a common pathologic change in both humans and mice with CIPN, and targeting galectin-3 is a proposed therapeutic option to delay CIPN progression. Schwann cell-derived galectin-3 plays a pronociceptive role via macrophage infiltration in the pathogenesis of taxane-induced peripheral neuropathy.
Article
Multidisciplinary Sciences
Shaheen A. Farhadi, Renjie Liu, Matthew W. Becker, Edward A. Phelps, Gregory A. Hudalla
Summary: Galectin-3 exhibits dynamic oligomerization and promiscuous binding, affecting cell behavior by influencing signaling pathways. Synthetic Gal3 constructs with defined valency can physically regulate extracellular signaling activity and cell death induction. Changes in multivalency impact caspase activation, membrane glycoprotein engagement, and intracellular pathway activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Sevgi Ozcan, Esra Donmez, Sevil Tugrul Yavuz, Murat Ziyrek, Orhan Ince, H. Suat Kucuk, Zeynep Atam Tasdemir, Ishak Yilmaz, Sinan Varol, Irfan Sahin, Ertugrul Okuyan
Summary: This study aimed to evaluate the role of serum galectin-3 levels in disease progression of COVID-19. The results showed that galectin-3 was associated with ICU transfer, need for advanced ventilatory support, and in-hospital mortality.
Article
Chemistry, Analytical
Maria Antonio, Tania Lima, Rita Ferreira, Margarida Fardilha, Jose Mesquita Bastos, Rui Vitorino, Ana. L. Daniel-da-Silva
Summary: In this study, a colorimetric and low-cost approach for detecting and quantifying Gal-3 using gold nanoparticles bioconjugated with Gal-3 antibody was developed. The method showed a linear response of the absorbance ratio to Gal-3 concentration, accompanied by a change in color intensity. It provided faster results and was more cost-effective compared to conventional detection techniques.
ANALYTICAL METHODS
(2023)
Article
Rheumatology
Eri Watanabe, Kazunori Kato, Takahisa Gono, Emiko Chiba, Chihiro Terai, Shigeru Kotake
Summary: The study found that serum galectin-3 levels were significantly higher in patients with IIM compared to healthy controls. Furthermore, galectin-3 levels correlated with inflammatory markers, cytokines, and disease activity indices. Patients with IIM-associated ILD had significantly higher levels of galectin-3, indicating its potential role as a biomarker of disease activity in this patient population.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.