Article
Nutrition & Dietetics
Hailun Xie, Lishuang Wei, Shunhui Gao, Mingxiang Liu, Yanren Liang, Guanghui Yuan, Qiwen Wang, Yansong Xu, Shuangyi Tang, Jialiang Gan
Summary: This study investigated the prognostic significance of sarcopenia diagnosed based on anthropometric equations for PFS and OS in CRC patients. Sarcopenia was found to be significantly associated with advanced age, large tumor size, and high mortality. Compared to non-sarcopenic patients, sarcopenic patients had worse PFS and OS. Predictive models based on sarcopenia were effective in predicting adverse outcomes in CRC patients.
FRONTIERS IN NUTRITION
(2023)
Article
Oncology
Mingkun Zhao, Minzhi Lv, Yuan Fang, Aobo Zhuang, Qian Wu, Hanxing Tong, Weiqi Lu, Yong Zhang
Summary: This study investigated the relationship between sarcopenia and severe postoperative complications, relapse-free survival, and overall survival in RLPS patients. The results showed that sarcopenia was associated with severe postoperative complications, but had no impact on relapse-free survival and overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Shingo Ono, Hiroto Furuhashi, Shunsuke Kisaki, Hideka Horiuchi, Hiroaki Matsui, Akira Dobashi, Hiroya Ojiri, Kazuki Sumiyama
Summary: This study investigated the prognostic factors associated with percutaneous endoscopic gastrostomy (PEG). It found that sarcopenia is negatively correlated with the prognosis after PEG. Among the 127 patients studied, approximately half (56%) had sarcopenia, and the study showed that patients with sarcopenia had shorter median survival time after PEG compared to those without. Therefore, sarcopenia is a predictive indicator of poor prognosis after PEG.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexey Surov, Hakan Kardas, Giulia Besutti, Massimo Pellegrini, Marta Ottone, Mehmet Ruhi Onur, Firat Atak, Ahmet Gurkan Erdemir, Elif Hocaoglu, Omer Yildiz, Ercan Inci, Eda Cingoz, Mehmet Cingoz, Memduh Dursun, Inan Korkmaz, Cagri Orhan, Alexandra Strobel, Andreas Wienke, Maciej Pech
Summary: The study aimed to evaluate the impact of low skeletal muscle mass on outcomes in patients with COVID-19. The results showed that the parameters of pectoralis muscle were associated with 30-day mortality, but they cannot be used for prediction of disease courses.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Till Dominik Best, Eric J. Roeland, Nora K. Horick, Emily E. Van Seventer, Areej El-Jawahri, Amelie S. Troschel, Patrick C. Johnson, Katie N. Kanter, Madeleine G. Fish, J. Peter Marquardt, Christopher P. Bridge, Jennifer S. Temel, Ryan B. Corcoran, Ryan D. Nipp, Florian J. Fintelmann
Summary: In patients with metastatic colorectal cancer, muscle loss may impact overall survival while weight loss does not show a significant association. Quantifying muscle loss on serial computed tomography scans may refine survival estimates beyond tumor mutational status.
Article
Medicine, General & Internal
Alessia Scatena, Pasquale Petruzzi, Filippo Maioli, Francesca Lucaroni, Cristina Ambrosone, Giorgio Ventoruzzo, Francesco Liistro, Danilo Tacconi, Marianna Di Filippi, Nico Attempati, Leonardo Palombi, Leonardo Ercolini, Leonardo Bolognese
Summary: The study showed that treatment with autologous PBMNC implants in NO-CLI patients with DFUs significantly reduced amputation rate, improved survival, and promoted wound healing. Autologous PBMNC injection may effectively prevent amputations in patients with DFUs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan-Chih Peng, Chien-Hui Wu, Yu-Wen Tien, Tzu-Pin Lu, Yu-Hsin Wang, Bang-Bin Chen
Summary: Preoperative sarcopenia assessed by CT is a poor prognostic factor for overall survival in pancreatic cancer patients after pancreaticoduodenectomy (PD).
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ting-Heng Chou, Jessica L. Alvelo, Sarah Janse, Xenophon Papademetris, Bauer E. Sumpio, Carlos Mena-Hurtado, Albert J. Sinusas, Mitchel R. Stacy
Summary: This study evaluated the prognostic value of SPECT/CT imaging of foot perfusion in predicting amputation outcomes in patients with critical limb ischemia and diabetes mellitus. The results showed that patients with lower microvascular perfusion response were more likely to undergo amputation, with high-perfusion responders having lower risk of amputation after revascularization.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riccardo Muglia, Matteo Simonelli, Federico Pessina, Emanuela Morenghi, Pierina Navarria, Pasquale Persico, Elena Lorenzi, Angelo Dipasquale, Marco Grimaldi, Marta Scorsetti, Armando Santoro, Letterio S. Politi
Summary: In our study, we found that in patients with glioblastoma at diagnosis, TMT was not associated with prognosis, age, or ECOG performance status.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Qianyi Wan, Zhetao Wang, Rui Zhao, Tingting Tu, Xiaoding Shen, Yuhou Shen, Tao Li, Yi Chen, Yinghan Song
Summary: CT-determined low SMM is associated with overall survival (OS) in gastric cancer patients, with a more significant prediction in patients with cachexia. Patients with synchronous low SMM and cachexia need more attention.
Article
Multidisciplinary Sciences
Takumi Noda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Takeshi Nakamura, Masashi Yamashita, Shota Uchida, Emi Maekawa, Jennifer L. Reed, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Summary: The study found that liver dysfunction was associated with reduced physical function in heart failure patients, and the coexistence of both significantly affected patient prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Ja Kyung Lee, Young Suk Park, Kanghaeng Lee, Sang Il Youn, Yongjoon Won, Sa-Hong Min, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
Summary: This study found that postoperative muscle loss and surgery-induced sarcopenia are prognostic factors for survival in patients with GC, with the impact on survival outcomes depending on sex.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Nutrition & Dietetics
Ting Liu, Xiaoping Yi, Jie Ge, Jinwei Zhang, Fengbo Tan, Kun Song, Heli Liu, Mimi Tang
Summary: This retrospective cohort study examined the influence of sex difference on the predictive role of sarcopenia in the long-term outcomes of patients with gastric cancer. The study found that muscle-related indicators were associated with outcomes in men, while adipose-related indicators were associated with outcomes in women.
FRONTIERS IN NUTRITION
(2022)
Review
Cell & Tissue Engineering
Zeinab Shirbaghaee, Mohammad Hassani, Saeed Heidari Keshel, Masoud Soleimani
Summary: This article reviews the immunomodulatory features of mesenchymal stem cells (MSCs) and their potential applications as therapeutic agents in the treatment of critical limb ischemia (CLI). Despite advances in clinical research, MSC therapy is still considered experimental and not recommended for regular clinical use. The article provides recommendations to improve the efficacy of cell therapy for CLI patients.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pathology
Peter Jung, David Horst, Thomas Kirchner, Frederick Klauschen, Jens Neumann
Summary: This study analyzed the prognostic value of AURKA in stage II colorectal cancer patients and examined the association of AURKA expression with patient survival and molecular markers. The results showed that AURKA H-Score is correlated with good overall survival and wild-type KRAS status.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Hematology
Yutaka Matsubara, Gathe Kiwan, Jia Liu, Luis Gonzalez, John Langford, Mingjie Gao, Xixiang Gao, Ryosuke Taniguchi, Bogdan Yatsula, Tadashi Furuyama, Takuya Matsumoto, Kimihiro Komori, Alan Dardik
Summary: In this study, it was found that T-cells precede macrophages in the remodeling AVF wall, and regulation of macrophage accumulation by T-cells is important for promoting AVF maturation. This research suggests that targeting T-cells during AVF maturation could be a potential strategy to improve AVF maturation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Xixiang Gao, Mingjie Gao, Jolanta Gorecka, John Langford, Jia Liu, Jiesi Luo, Ryosuke Taniguchi, Yutaka Matsubara, Hao Liu, Lianrui Guo, Yongquan Gu, Yibing Qyang, Alan Dardik
Summary: Research suggests that treatment using human iPSC-derived smooth muscle cells in a murine hindlimb ischemia model can improve functional outcomes and blood flow, increase muscle fiber area and capillary density, reduce macrophage numbers, and enhance vascular endothelial growth factor expression in ischemic limbs.
Article
Surgery
Shun Kurose, Yutaka Matsubara, Shinichiro Yoshino, Ken Nakayama, Sho Yamashita, Koichi Morisaki, Tadashi Furuyama, Masaki Mori
Summary: Through a retrospective study of patients undergoing EVAR, it was found that IIAE is associated with postoperative sarcopenia, with IIAE independently increasing the risk of postoperative sarcopenia, and patients who develop postoperative sarcopenia have a lower overall survival rate.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Surgery
Yoshino Shinichiro, Yutaka Matsubara, Tadashi Furuyama, Shun Kurose, Sho Yamashita, Koichi Morisaki, Masaki Mori
Summary: This study investigated the natural history of iliac artery aneurysms in a Japanese cohort and found that larger aneurysms have greater expansion rates. Iliac artery aneurysms with a diameter of >= 30 mm carry a high risk of rupture and should be carefully followed up and considered for surgical intervention.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Surgery
Koichi Morisaki, Yutaka Matsubara, Shinichiro Yoshino, Shun Kurose, Sho Yamashita, Tadashi Furuyama, Masaki Mori
Summary: This study examined the relationship between GLASS stage and treatment outcomes in patients with chronic limb-threatening ischemia (CLTI) who underwent infrainguinal revascularization. The results showed that GLASS stage did not affect limb salvage or wound healing, but it was a prognostic factor for poor overall survival (OS). However, WIfI stage and inframalleolar (IM) disease were found to be risk factors for major amputation and impaired wound healing.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Koichi Morisaki, Yutaka Matsubara, Tadashi Furuyama, Shun Kurose, Shinichiro Yoshino, Sho Yamashita, Masaki Mori
Summary: This study evaluated the influence of antiplatelet or anticoagulant therapy on sac behavior after endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA). The results showed that antiplatelet therapy is associated with the lack of sac regression at 1 year, while both antiplatelet and anticoagulant therapies are risk factors for late sac expansion.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Surgery
Koichi Morisaki, Yutaka Matsubara, Shun Kurose, Shinichiro Yoshino, Tadashi Furuyama
Summary: This study aimed to determine factors related to relief from rest pain, wound healing, major adverse limb events (MALEs), and prognosis after infrainguinal revascularisation in patients with chronic limb threatening ischaemia (CLTI). The results showed that bypass surgery was superior to endovascular therapy (EVT) in terms of the composite endpoint, including relief from rest pain, wound healing, MALE, or death. Therefore, bypass surgery may be considered as the preferred treatment.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Peripheral Vascular Disease
Koichi Morisaki, Yutaka Matsubara, Shun Kurose, Shinichiro Yoshino, Tadashi Furuyama
Summary: The present study found that CONUT, PNI, and GNRI scores can predict the 2-year overall survival in patients with CLTI after revascularization. CONUT and PNI scores were associated with major amputation.
Article
Peripheral Vascular Disease
Jia Liu, Dingyao Zhang, Anand Brahmandam, Yutaka Matsubara, Mingjie Gao, Jingru Tian, Bing Liu, Chang Shu, Alan Dardik
Summary: This study reveals the activation of inflammatory and immune responses during arteriovenous fistula (AVF) maturation. The regulation of genes associated with AVF maturation differs between male and diabetic patients. Diabetes may impair AVF maturation by altering inflammatory and immune responses.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Surgery
Koichi Morisaki, Daisuke Matsuda, Yutaka Matsubara, Shun Kurose, Shinichiro Yoshino, Go Kinoshita, Kenichi Honma, Terutoshi Yamaoka, Tadashi Furuyama, Tomoharu Yoshizumi
Summary: This study aimed to analyze the influence of the Global Anatomic Staging System (GLASS) and inframalleolar (IM) disease on the treatment outcomes of patients with chronic limb threatening ischaemia (CLTI) who undergo endovascular treatment (EVT). The study found that IM disease and GLASS stage were associated with major amputation, major adverse limb events (MALE), and wound healing, while GLASS stage was only associated with MALE.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Editorial Material
Surgery
Koichi Morisaki, Daisuke Matsuda, Yutaka Matsubara, Terutoshi Yamaoka, Tadashi Furuyama, Tomoharu Yoshizumi
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Peripheral Vascular Disease
Yutaka Matsubara, Shogo Kawanami, Go Kinoshita, Shun Kurose, Yoshino Shinichiro, Koichi Morisaki, Tadashi Furuyama, Tomoharu Yoshizumi
Summary: Objective Postoperative limb infection is associated with poor prognosis and low amputation-free survival rate after surgical revascularization in patients with critical limb-threatening ischemia. This study provides new evidence supporting the use of perioperative therapeutic antibiotics in these patients.
Article
Physiology
Shun Kurose, Yutaka Matsubara, Shinichiro Yoshino, Keiji Yoshiya, Koichi Morisaki, Tadashi Furuyama, Tomoaki Hoshino, Tomoharu Yoshizumi
Summary: Macrophages play crucial roles in AAA formation through inflammation and matrix degradation. IL-38, which has an anti-inflammatory effect, may suppress AAA formation by regulating macrophages. In this study, IL-38 treatment reduced M1 macrophage accumulation and MMP-2 and -9 expression in the AAA wall, leading to a decreased incidence of AAA. Additionally, p38 phosphorylation was found to be involved in the protective effects of IL-38 on regulating macrophages and reducing AAA incidence.
PHYSIOLOGICAL REPORTS
(2023)
Article
Surgery
Koichi Morisaki, Daisuke Matsuda, Atsushi Guntani, Yutaka Matsubara, Go Kinoshita, Shogo Kawanami, Sho Yamashita, Kenichi Honma, Tadashi Furuyama, Terutoshi Yamaoka, Shinsuke Mii, Kimihiro Komori, Tomoharu Yoshizumi
Summary: This study compared the outcomes of bypass surgery and endovascular therapy (EVT) in patients with chronic limb-threatening ischemia (CLTI). It was found that bypass surgery, which is preferred according to global vascular guidelines, can achieve better limb salvage and wound healing compared to EVT.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Koichi Morisaki, Atsushi Guntani, Go Kinoshita, Shogo Kawanami, Sho Yamashita, Yutaka Matsubara, Tadashi Furuyama, Shinsuke Mii, Kimihiro Komori, Tomoharu Yoshizumi
Summary: This study aimed to evaluate the influence of change in ambulatory status on the prognosis of patients with chronic limb-threatening ischemia (CLTI) undergoing infrainguinal bypass surgery or endovascular therapy (EVT). The results showed that improved ambulatory status is associated with better overall survival in patients with preoperative nonambulatory status after infrainguinal revascularization for CLTI.
JOURNAL OF VASCULAR SURGERY
(2023)