Article
Biochemistry & Molecular Biology
Maria Carola Fiore, Sebastiano Blangiforti, Giovanni Preiti, Alfio Spina, Sara Bosi, Ilaria Marotti, Antonio Mauceri, Guglielmo Puccio, Francesco Sunseri, Francesco Mercati
Summary: By evaluating the genetic diversity of wheat germplasm from Sicily and Calabria, this study identified distinct groups among different species and subspecies of Triticum. The research also revealed different gene pools between improved varieties and ancient varieties. This study is important for the preservation of landraces and ancient varieties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Lovepreet Singh, Yanqi Wu, James D. McCurdy, Barry R. Stewart, Marilyn L. Warburton, Brian S. Baldwin, Hongxu Dong
Summary: This study investigated the genetic diversity of 206 bermudagrass accessions using genetic markers. Four subpopulations were identified, indicating a high level of genetic variation in bermudagrass. These findings provide valuable resources for further breeding programs and cultivar development.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Microbiology
Jelmer B. Jukema, Bernice M. Hoenderboom, Birgit H. B. van Benthem, Marianne A. B. Van der Sande, Henry J. C. de Vries, Christian J. P. A. Hoebe, Nicole H. T. M. Dukers-Muijrers, Caroline J. Bax, Servaas A. Morre, Sander Ouburg
Summary: Clear inter-individual differences in response to C. trachomatis infections exist, with certain genes' SNPs potentially influencing susceptibility and severity. NOD1 and IL10 gene SNPs may increase the risk of infection and late complications such as ectopic pregnancy or infertility. Further confirmatory studies on a larger scale are needed to explore the role of SNPs in CT infections.
Article
Medical Laboratory Technology
Jung Wook Kim, Kwang Jun Lee
Summary: This study developed a rapid and accurate method for detecting vancomycin-resistant Staphylococcus aureus (S. aureus) infection. Four SNPs associated with reduced susceptibility to vancomycin were identified through a genome-wide association study, mainly found in ST5 lineage. The TaqMan SNP genotyping assay successfully detected these four SNPs, providing a potential alternative for the rapid detection of vancomycin-resistant S. aureus in ST5 epidemic lineage.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kyoung Lae Kim, Hyerim Kim, Youngju Lee, Cheolju Lee, Kwangsic Joo, Sang Jun Park, Kyu Hyung Park, Seong-Jun Park, Se Joon Woo
Summary: This study successfully determined the genotypes of CFH SNP Y402H and I62V by measuring plasma protein concentrations of CFH variants using the multiple reaction monitoring (MRM) assay, providing a new method for studying the genetic risk factors of age-related macular degeneration (AMD).
SCIENTIFIC REPORTS
(2022)
Article
Entomology
Tyler Jay Raszick, Lindsey C. Perkin, Alejandra Godoy, Xanthe A. Shirley, Karen Wright, Paxton T. Martin, Charles P. -C. Suh, Raul Ruiz-Arce, Gregory A. Sword
Summary: Rapid and accurate identification of Anthonomus grandis subspecies is crucial for effective management and eradication. We validated a custom TaqMan SNP Genotyping Assay, which demonstrated high sensitivity, specificity, and accuracy. The entire workflow can be completed within a single workday, enabling same-day diagnosis of trapped specimens and benefiting management and eradication programs.
Article
Biochemistry & Molecular Biology
Ruslan Kalendar, Alexandr V. Shustov, Ilyas Akhmetollayev, Ulykbek Kairov
Summary: This article introduces a bioinformatic tool for PCR-based genotyping assays, which allows design of probe sequences, discrimination of allelic variants, and enhances reaction specificity and discriminative power, offering greater likelihood of research success.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Forestry
Xue Gong, Aihong Yang, Zhaoxiang Wu, Caihui Chen, Huihu Li, Qiaoli Liu, Faxin Yu, Yongda Zhong
Summary: The genetic diversity of Cinnamomum camphora populations was highest in western China and lowest in eastern China, with the Japanese population showing the highest diversity. There was low genetic differentiation among populations, possibly indicating gene exchange. The study provides genetic tools for the utilization of C. camphora germplasm resources.
Article
Clinical Neurology
Shilin Li, Shiyao Yang, Xiaobo Zhang, Yu Zhang, Jie Zhang, Xiao Zhang, Weiping Li, Xiaochen Niu, Wenzhen Shi, Gejuan Zhang, Mingze Chang, Ye Tian
Summary: This study found a significant association between rs243849 and rs14070 in MMP2 and the risk of IS in the Chinese Shaanxi population. Specifically, rs14070 in MMP2 was found to reduce the risk of IS. Subgroup analysis revealed that rs243849 in MMP2 increased the risk of IS among drinkers, while rs14070 in MMP2 reduced IS susceptibility among females, participants aged >55, smokers, and drinkers.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Legal
Miwha Chang, Joo-Young Kim, Haeyong Lee, Eun-jung Lee, Won-Hae Lee, Seohyun Moon, Sanggil Choe, Chong Min Choung
Summary: In this study, we identified SNPs within the region of two universal DNA barcodes, matK and trnL-trnF, that can be used for distinguishing opium poppy species. The newly identified SNPs play a key role in differentiating between narcotic and non-narcotic types of Papaver species.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Infectious Diseases
Puja Neopane, Jerome Nypaver, Rojeet Shrestha, Safedin Sajo Beqaj
Summary: The study evaluated the performance of TaqMan SARS-CoV-2 mutation panel genotyping molecular assay for detection of SARS-CoV-2 variants. Results showed that the assay could effectively detect and differentiate various common variants, providing a useful tool for epidemic surveillance and control.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Oncology
Guanwu Wang, Lara Rosaline Heij, Dong Liu, Edgar Dahl, Sven Arke Lang, Tom Florian Ulmer, Tom Luedde, Ulf Peter Neumann, Jan Bednarsch
Summary: This systematic review evaluated the association between single-nucleotide polymorphisms (SNPs) and cholangiocarcinoma (CCA), focusing on tumorigenesis and prognosis. Based on 34 studies, a total of 43 SNPs in 32 genes associated with CCA risk, metastatic progression, and overall prognosis were identified. The study comprehensively described the mechanisms and potential clinical implications associated with these SNPs. The findings suggest that multiple SNPs play different roles at different stages of CCA and may serve as biomarkers for guiding treatment and assessing oncological risk.
Article
Plant Sciences
Hong Chen, Zegang Han, Qi Ma, Chengguang Dong, Xinzhu Ning, Jilian Li, Hai Lin, Shouzhen Xu, Yiqian Li, Yan Hu, Zhanfeng Si, Qingping Song
Summary: Genome-wide association studies (GWAS) identified multiple SNP loci associated with cotton fiber quality, providing valuable molecular markers and genetic resources for future cotton breeding. The study also analyzed the correlations among fiber length, fiber strength, micronaire, uniformity, and elongation, revealing important insights into these fiber quality traits.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agricultural Engineering
Zhanfeng Si, Shangkun Jin, Jiangyu Li, Zegang Han, Yiqian Li, Xiaonv Wu, Yunxia Ge, Lei Fang, Tianzhen Zhang, Yan Hu
Summary: This article reports the development of a liquid SNP chip named ZJU CottonSNP40K through genotyping by target sequencing, along with its utility. The chip has high genotyping efficiency and accuracy, and will facilitate cotton functional studies and molecular breeding.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biotechnology & Applied Microbiology
Nicholas P. Howard, Michela Troggio, Charles-Eric Durel, Helene Muranty, Caroline Denance, Luca Bianco, John Tillman, Eric van de Weg
Summary: This study assessed the concordance and accuracy of Illumina Infinium and Affymetrix Axiom SNP array data in apple genomes. The majority of the data was found to be compatible, although intense data filtering and curation were required for data integration. This in-depth analysis may provide valuable insights for future work on SNP array data integration and interpretation, as well as for probe/platform development.
Article
Neurosciences
Andrea Accogli, Shenzhao Lu, Ilaria Musante, Paolo Scudieri, Jill A. Rosenfeld, Mariasavina Severino, Simona Baldassari, Michele Iacomino, Antonella Riva, Ganna Balagura, Gianluca Piccolo, Carlo Minetti, Denis Roberto, Fan Xia, Razaali Razak, Emily Lawrence, Mohamed Hussein, Emmanuel Yih-Herng Chang, Michelle Holick, Elisa Cali, Emanuela Aliberto, Rosalba De-Sarro, Antonio Gambardella, Lisa Emrick, Peter J. A. McCaffery, Margaret Clagett-Dame, Paul C. Marcogliese, Hugo J. Bellen, Seema R. Lalani, Federico Zara, Pasquale Striano, Vincenzo Salpietro
Summary: This study identified a new neurodevelopmental disorder caused by loss of the NAV2 gene, highlighting a critical conserved role of the NAV2 gene in brain and cerebellar development.
Article
Clinical Neurology
Emanuele Cerulli Irelli, Enrico Cocchi, Georgia Ramantani, Antonella Riva, Roberto Horacio Caraballo, Alessandra Morano, Loretta Giuliano, Tulay Yilmaz, Eleni Panagiotakaki, Francesca F. Operto, Beatriz Gonzalez Giraldez, Simona Balestrini, Katri Silvennoinen, Sara Casciato, Marion Comajuan, Francesco Fortunato, Anna Teresa Giallonardo, Rimma Gamirova, Antonietta Coppola, Giancarlo Di Gennaro, Angelo Labate, Vito Sofia, Gerhard Josef Kluger, Antonio Gambardella, Dorothee G. A. Kasteleijn-NolstTrenite, Betul Baykan, Sanjay M. Sisodiya, Alexis Arzimanoglou, Pasquale Striano, Carlo Di Bonaventura
Summary: Based on age at epilepsy onset (AEO), this study identified three subtypes of objective epilepsy with eyelid myoclonia (EEM) and analyzed their distinct clinical features. Early onset EEM was associated with higher rates of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities, while late onset EEM had the highest proportion of myoclonia involving body regions other than eyelids and generalized tonic-clonic seizures. Intermediate onset EEM had the lowest observed rate of additional findings. Family history of EEM was more frequent in the subtypes with intermediate and late onset. Patients with body-MYO showed higher rates of migraine and generalized tonic-clonic seizures.
Article
Clinical Neurology
Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson
Summary: A significant proportion of Charcot-Marie-Tooth disease (CMT) patients experience general distress and depression, which are correlated with disease severity and medication usage.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Giuseppe Magro, Stefania Barone, Federico Tosto, Antonio De Martino, Domenico Santange Lo, Lucia Manzo, Angelo Pascarella, Pietro Bruno, Marilisa Pasquale, Antonio Gambardella, Paola Valentino
Summary: This study investigated the occurrence of wearing-off symptoms (WoS) in patients treated with Natalizumab using an extended interval dosing (ExID) compared to standard interval dosing (StID). The results showed no significant difference in the prevalence of WoS between the ExID and StID groups, but WoS was strongly correlated with higher EDSS and FSS. The safety and efficacy of Natalizumab with ExID were relatively preserved in this cohort of patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Yuri Falzone, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson
Summary: This study investigated fatigue in CMT patients and found that 36% of the patients experienced abnormal fatigue. Abnormal fatigue was correlated with disease severity, anxiety, depression, sleepiness, and obesity. Therefore, the management of CMT patients should involve treating fatigue and addressing other factors such as anxiety, depression, sleepiness, and obesity.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Monica Gagliardi, Radha Procopio, Mariagrazia Talarico, Andrea Quattrone, Gennarina Arabia, Maurizio Morelli, Marco D'Amelio, Donatella Malanga, Giuseppe Bonapace, Aldo Quattrone, Grazia Annesi
Summary: Recently, a novel pathogenic variant in Annexin A1 protein has been identified in an Iranian family with autosomal recessive Parkinsonism. This study aimed to identify rare ANXA1 variants in early-onset PD patients from South Italy. However, sequencing analysis revealed only 2 synonymous variants, suggesting that the recently published ANXA1 mutation is not a common cause of EOPD in Southern Italy.
NEUROBIOLOGY OF AGING
(2023)
Article
Virology
Claudia Veneziano, Nadia Marascio, Carmela De Marco, Barbara Quaresima, Flavia Biamonte, Enrico Maria Trecarichi, Gianluca Santamaria, Angela Quirino, Daniele Torella, Aldo Quattrone, Giovanni Matera, Carlo Torti, Caterina De Filippo, Francesco Saverio Costanzo, Giuseppe Viglietto
Summary: We investigated the evolution of SARS-CoV-2 spread in Calabria, Southern Italy, in 2022. Analysis of Omicron variants in Calabria revealed the prevalence of 10 different sub-lineages. In addition, Calabria Omicron presented non-canonical mutations in the S protein and non-structural proteins.
Review
Clinical Neurology
Andrea Quattrone, Anna Latorre, Francesca Magrinelli, Eoin Mulroy, Roopa Rajan, Ray Jen Neo, Aldo Quattrone, John C. Rothwell, Kailash P. Bhatia
Summary: In this review, we discuss the clinical and pathophysiological aspects of various motor phenomena in patients with movement disorders. These phenomena, including mirror movements and dystonic overflow, share some similarities but also differ in terms of the body part involved, the type of movement, and the underlying neurological condition. We aim to improve the clinical recognition and standardize the terminology of these fascinating clinical signs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Alessia Giugno, Iolanda Martino, Ilaria Sammarra, Enrico Fratto, Francesco Fortunato, Angelo Labate, Antonio Gambardella
Summary: Global neuropsychological impairments with intellectual disability (ID) appear to be a major factor in the occurrence of psychogenic non-epileptic seizures (PNES) in epilepsy. However, the underlying pathophysiology of PNES in patients with epilepsy without ID is still unknown. In this study, the neuropsychiatric profile of subjects with temporal lobe epilepsy (TLE) and PNES (TLE + PNES), compared to those with TLE alone and PNES alone, was investigated. The results showed that TLE + PNES and PNES groups had a similar psychiatric profile with higher levels of depression, anxiety, dissociation, and alexithymia scales compared to the TLE group. The low rate of potentially traumatizing events in the TLE + PNES group suggests that epilepsy itself may contribute to the development of PNES.
Article
Clinical Neurology
Rebekah V. Harris, Karen L. Oliver, Piero Perucca, Pasquale Striano, Angelo Labate, Antonella Riva, Bronwyn E. Grinton, Joshua Reid, Jessica Hutton, Marian Todaro, Terence J. O'Brien, Patrick Kwan, Lynette G. Sadleir, Saul A. Mullen, Emanuela Dazzo, Douglas E. Crompton, Ingrid E. Scheffer, Melanie Bahlo, Carlo Nobile, Antonio Gambardella, Samuel F. Berkovic
Summary: This study analyzed 134 families with familial mesial temporal lobe epilepsy (FMTLE) and found that FMTLE is a generally mild drug-responsive syndrome with the main symptom being déjà vu. Unlike monogenic focal epilepsy syndromes, molecular data supports a polygenic basis for FMTLE. The polygenic risk score (PRS) data suggests that sub-genome-wide significant focal epilepsy genome-wide association study single nucleotide polymorphisms are important risk variants for FMTLE.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Emanuele Cerulli Irelli, Joanna Gesche, Sophie Schlabitz, Francesco Fortunato, Cecilia Catania, Alessandra Morano, Angelo Labate, Bernd J. Vorderwuelbecke, Antonio Gambardella, Betuel Baykan, Martin Holtkamp, Carlo Di Bonaventura, Christoph P. Beier
Summary: This multicenter retrospective study investigated the electroclinical features, seizure outcome, and antiseizure medication withdrawal in a large cohort of GTCA patients. The study found a low rate of drug resistance and a high prevalence of early response to treatment in GTCA patients.
Letter
Clinical Neurology
Anna Gardin, Marco Cavallaro, Angelo Labate
Summary: The diagnosis of herpes simplex encephalitis (HSE) can be challenging due to its variable clinical presentation and atypical radiological features. Brain MRI plays a crucial role in identifying mimicking conditions, such as ischemic strokes, through accurate interpretation of specific sequences. This report highlights a case of misdiagnosed HSE, emphasizing the importance of MRI in the emergency setting.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Camilla Calomino, Andrea Quattrone, Alessia Sarica, Maria Giovanna Bianco, Federica Aracri, Marida De Maria, Jolanda Buonocore, Maria Grazia Vaccaro, Basilio Vescio, Aldo Quattrone
Summary: Objective: The study aimed to identify brain structures associated with postural instability (PI) in Progressive Supranuclear Palsy (PSP). Methods: PSP patients and control subjects were evaluated using voxel-based morphometry (VBM). Results: Widespread grey matter atrophy was observed in PSP patients compared to controls. The right inferior frontal gyrus (IFG) was significantly associated with the PI score in PSP patients. Conclusions: The IFG volume may play a role in the pathophysiological mechanisms underlying PI. This finding has important implications for developing optimal treatment protocols for postural disorders in parkinsonism.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Marco Mula, Simon Borghs, Bruno Ferro, Gaetano Zaccara, Filippo Dainese, Edoardo Ferlazzo, Andrea Romigi, Antonio Gambardella, Emilio Perucca
Summary: This study aimed to investigate the changes in depressive and suicidality status and their relationship with seizure outcomes after the addition or substitution of another antiseizure medication (ASM) in adults with drug-resistant focal epilepsy. The results showed that almost 1 in 5 adults with drug-resistant focal epilepsy who tested negative for depression became positive after a treatment change, and 6.1% of patients who initially tested negative for passive suicidal ideation became positive after 6 months. These changes were independent of the type of ASM introduced or seizure outcomes, but were correlated with psychiatric status at baseline.
Meeting Abstract
Biochemistry & Molecular Biology
Mariagrazia Talarico, Radha Procopio, Monica Gagliardi, Donatella Malanga, Antonio Gambardella, Grazia Annesi
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
