Article
Medicine, General & Internal
Tomohiko Sakuda, Taisuke Furuta, Tomoaki Okimoto, Nobuo Adachi
Summary: This case study suggests that carbon ion radiotherapy is a safe and effective therapeutic option for patients with recurrent GCT of the cervical spine, providing the potential for long-term remission.
Article
Plant Sciences
Yoshihiro Hase, Katsuya Satoh, Satoshi Kitamura
Summary: The molecular nature of mutations induced by ionizing radiation and chemical mutagens in plants is better understood with the help of high-throughput DNA sequencing technology. This study compared the mutations induced by gamma rays and carbon ions in Arabidopsis, both in dry-seeds and seedlings. The results revealed differences in mutation frequency and types induced by different radiation qualities and materials, and provide useful information for selecting suitable radiation treatments for mutagenesis.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Crystallography
Sina Mayr, Simone Finizio, Joakim Reuteler, Stefan Stutz, Carsten Dubs, Markus Weigand, Ales Hrabec, Jorg Raabe, Sebastian Wintz
Summary: This study focuses on obtaining soft X-ray transparent windows using xenon plasma focused ion beam (PFIB) milling, with an empirical method to determine the transmission level of the windows during fabrication. Additionally, scanning transmission X-ray microscopy (STXM) imaging is used to demonstrate the feasibility of the technique. The thinning approach provides a fast and simplified method for soft X-ray transmission measurements of epitaxial samples.
Article
Genetics & Heredity
Navdeep Malik, Hualong Yan, Howard H. Yang, Gamze Ayaz, Wendy DuBois, Yu-Chou Tseng, Young-Im Kim, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Jing Huang
Summary: CBFB is a tumor suppressor gene frequently mutated in solid tumors, especially in breast cancer. It cooperates with TP53 to maintain the expression of TAp73, which acts as a mediator for the tumor suppressive function of p53. Loss of TAp73 expression enhances the tumorigenic effect of CBFB and is a common event in human breast cancer. This study provides insights into the functional association between CBFB and p53 in breast cancer and has implications for precision medicine.
Review
Materials Science, Ceramics
S. A. Ghyngazov, V. A. Boltueva
Summary: This paper provides a literature review on the effects of ion irradiation on ceramic materials. Comparisons are made between the effects on metals and alloys versus ceramics, revealing common patterns of ion exposure effects. The focus is on the microstructure, phase state, and hardness of ceramics under this treatment, along with the determination of common patterns of structural and phase transformations and surface modification effects.
CERAMICS INTERNATIONAL
(2023)
Article
Oncology
D. S. Prabakaran, Pankaj Kumar Chaturvedi, Takashi Shimokawa, Ki-Hwan Kim, Woo-Yoon Park
Summary: Silencing of FTS enhances the radiosensitivity of cervical cancer cells to Carbon ion radiation by downregulating Notch signaling molecules and decreasing the survival of cancer stem cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Physical
Masedi Carington Masekane, Ivancica Bogdanovic Radovic, Mandla Msimanga, Sabata Jonas Moloi
Summary: Particle Induced X-ray Emission (PIXE) spectroscopy is a well-established analytical technique, especially for low projectile mass. The availability of accurate theoretical models is crucial for the development of PIXE. This study aims to contribute to the database of heavy ion induced X-ray production cross sections by providing new experimental data.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Review
Chemistry, Physical
Wenjun Ma
Summary: This paper reviews the advances in using nanotechnology and nanomaterials for laser-driven particle acceleration, with a focus on carbon nanotubes as targets. The successful implementation of these methods is expected to promote the development of this field.
Article
Chemistry, Physical
Luis Kitsu Iglesias, Emma N. Antonio, Tristan D. Martinez, Liang Zhang, Zengqing Zhuo, Steven J. Weigand, Jinghua Guo, Michael F. Toney
Summary: This study elucidates the mechanism of sodium storage in hard carbon anodes and provides insights into the preferred pore sizes, extent of pore filling, and the influence of defect concentration. It is observed that sodium in larger pores exhibits increased pseudo-metallic sodium character, and higher pyrolysis temperatures enhance the capacity of sodium stored in the pores. Additionally, sodium intercalation between graphene layers occurs simultaneously with pore filling in the plateau region. The findings highlight strategies to design superior hard carbon anodes for sodium-ion batteries.
ADVANCED ENERGY MATERIALS
(2023)
Article
Physics, Applied
Reimi Miyamoto, Akio Nishiyama, Ryota Yoshikawa, Junji Taguchi, Keiji Komatsu, Hidetoshi Saitoh
Summary: This study investigated the refractive index and extinction coefficient of diamond-like carbon films formed by gas cluster ion beam-assisted deposition. Based on the values of n and k at lambda = 2.25 eV, DLC films were classified into four types. The study focused on the nonclassified DLC film, which had high values of n (2.4-3.0) and k (0.75-1.0). The Raman peak intensity ratio of this film corresponded to a-C:H or ta-C:H and the film density was 2.71 g cm(-3). The nonclassified DLC film exhibited intermediate properties between a-C:H and ta-C:H in terms of density and k.
APPLIED PHYSICS EXPRESS
(2022)
Article
Oncology
Kazumasa Sekihara, Hidetomo Himuro, Nao Saito, Yukihide Ota, Taku Kouro, Yohsuke Kusano, Shinichi Minohara, Ryoichi Hirayama, Hiroyuki Katoh, Tetsuro Sasada, Daisuke Hoshino
Summary: Cervical adenocarcinoma is a challenging cancer to detect early and treat with resistance to conventional therapies. Heavy-particle radiotherapy may offer a new treatment strategy to overcome this resistance.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Physical
Kritika Singh, Surya Snata Rout, Christina Krywka, Anton Davydok
Summary: This study analyzed lattice distortion and ion implantation in metallic micropillars prepared using plasma focus ion beam (PFIB) milling. Higher Xe ion energy led to higher density of implanted ions within the redeposited and milled material. Mixing of ions significantly influenced lattice structure, causing deformation in regions with higher ion concentrations.
Article
Cell Biology
Vivek Kumar, Mohit Vashishta, Lin Kong, Jiade J. Lu, Xiaodong Wu, Bilikere S. Dwarakanath, Chandan Guha
Summary: Photon-based radiotherapy and carbon ion radiotherapy have different effects on Notch signaling in glioma cells. Carbon ion radiotherapy regulates the expression of Notch signaling and reduces stemness and cell migration. These findings may contribute to reducing tumor regrowth and disease dissemination.
Article
Chemistry, Physical
Flavien Ralite, Charbel Koumeir, Arnaud Guertin, Ferid Haddad, Quentin Mouchard, Noel Servagent, Vincent Metivier
Summary: Recent works have demonstrated the feasibility of using bremsstrahlung radiation as a non-invasive tool for monitoring proton beams. Experimental results support the use of bremsstrahlung X-ray models in developing promising online tools for proton beam monitoring.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Physical
Antoine Laine, Rahul Parmar, Matteo Amati, Luca Gregoratti, Gregory Su, Ting Xu, Miquel Salmeron
Summary: Researchers have found that graphene can serve as an x-ray and electron transparent substrate, reducing radiation damage to oxide thin films. This discovery opens up possibilities for the development of experimental setups with limited sample damage.
APPLIED SURFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ruixin Zhang, Junwu Liu, Genlong Xue, Jiming Yang, Desheng Li, Tao Tian, Xiaofang Zhang, Kangyi Gao, Zhenwei Pan
Summary: This study successfully reduced the susceptibility to arrhythmia and improved cardiac conduction in conventional heart failure mice by activating dystrophin expression using the CRISPR-dCas9 system. It also restored the membrane distribution of Nav1.5. This provides a new strategy for the treatment of heart failure-related ventricular arrhythmia.
Article
Chemistry, Multidisciplinary
Ying Zhang, Yi-yuan Zhang, Zhen-wei Pan, Qing-qi Li, Li-hua Sun, Xin Li, Man-yu Gong, Xue-wen Yang, Yan-ying Wang, Hao-dong Li, Li-na Xuan, Ying-chun Shao, Meng-meng Li, Ming-yu Zhang, Qi Yu, Zhange Li, Xiao-fang Zhang, Dong-hua Liu, Yan-meng Zhu, Zhong-yue Tan, Yuan-yuan Zhang, Yun-qi Liu, Yong Zhang, Lei Jiao, Bao-feng Yang
Summary: This study found that GDF11 can accelerate the healing of diabetic wounds by promoting neovascularization and regeneration of skin tissues through cellular and molecular mechanisms. Topical application of GDF11 stimulates the mobilization of endothelial progenitor cells and enhances neovascularization through the HIF-1 alpha-VEGF/SDF-1 alpha pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Optics
Jing Bai, Xuan Liu, Cheng-xian Ge, Zhen-sen Wu, Xiao-xiao Zhang
Summary: We studied the optical trapping force exerted on non-uniform chiral stratified spheres using a high-order Bessel beam. By comparing with existing reference, we validated the present theories. Numerical simulations considering various parameters showed that different chirality distributions significantly affect the trapping characteristics, and a stable three-dimensional capture can be achieved by selecting appropriate incident beam and particle parameters. These theoretical investigations offer an analytical method for understanding the interaction between light and more complex stratified chiral cells, thus providing an encouraging approach for designing better optical manipulation systems.
Article
Engineering, Electrical & Electronic
Shaojie Chang, Zhenhua Wu, Diwei Liu, Renbin Zhong, Zhaoyun Duan, Yanyu Wei, Yubin Gong, Min Hu
Summary: A novel method for extracting and amplifying the third harmonic of an electron beam to generate high-power terahertz radiation is presented. This approach utilizes three planar grating structures operating in the backwave region to extract and amplify the electron beam from the fundamental modulation, resulting in an amplified output of the fundamental wave and a high power output of the fundamental triplet frequency. The planar grating structure is easier to machine and assemble compared to conventional harmonic amplifiers and allows for increased electron beam flow rate.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Zhaohao Zhang, Shujuan Mao, Gaobo Xu, Qingzhu Zhang, Zhenhua Wu, Huaxiang Yin, Tianchun Ye
Summary: An ultra-dense one-transistor (1T) ternary content addressable memory (TCAM) array is reported, based on high-performance, non-volatile, and ambipolar ferroelectric (Fe) silicon-on-insulator (SOI) fin field-effect transistors (FinFETs). TCAM functions were realized on a single device due to the multistates in the Fe layer and ambipolar characteristics. This has potential for Hamming-distance computing in area-and energy-efficient artificial intelligence (AI) processors.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Haoqing Xu, Jiaxin Yao, Zhizhen Yang, Lei Cao, Qingzhu Zhang, Yongliang Li, Anyan Du, Huaxiang Yin, Zhenhua Wu
Summary: This article presents a physics-based simulation study of a Si-core-SiGe-shell gate-all-around nanosheet FET. The study evaluates the effect of various factors on electrostatics and transport properties and suggests that the proposed core-shell structure is a potential candidate for advanced technology nodes.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Automation & Control Systems
Srinivasa Naik Bhukya, Zhenhua Wu, Abdelmageed Elmustafa, Aiman Al-Allaq, Manish Ojha, Yousuf Mohammed
Summary: This research investigates the effects of copper (Cu) donor material assisted friction stir welding (FSW) on AA2024-T4 and AA6061-T6 plates of 6.35 mm thickness. By introducing Cu donor material, the downward force generated during FSW process is gradually decreased, and the temperature at the beginning of welding process is increased. Defect-free joints with improved tensile strength can be obtained by placing high strength AA2024 alloy at the advancing side of the weld with 25% thick donor material. SEM Fractography images confirm mixed modes of brittle and ductile fracture surfaces after the inclusion of donor material in FSW.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Oncology
Ying Lin, Bo Yu, Haifeng Sun, Hongyu Zhang, Zhihuang Hu, Yao Zhang, Zhenhua Wu, Si Sun, Xinmin Zhao, Hui Yu, Xianghua Wu, Yuan Li, Jialei Wang, Huijie Wang
Summary: This research explored the efficacy of different treatments in thoracic SMARCA4-deficient undifferentiated tumor (SD-UT) and compared the differences in prognosis, clinicopathology, and genomics between SD-UT and SMARCA4-deficient non-small cell lung cancer (SD-NSCLC). The study found that immune checkpoint inhibitor (ICI) plus chemotherapy significantly improved progression-free survival in Stage IV SD-UT patients. The genetic study revealed frequent mutations of SMARCA4, TP53, and LRP1B in SD-UT.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Pengcheng Zuo, Yaopeng Li, Tantan Wang, Xingyu Lin, Zhen Wu, Junting Zhang, Xuebin Liao, Liwei Zhang
Summary: In this study, a novel CDK4/6 inhibitor YF-PRJ8-1011 was designed and synthesized, which exhibited more potent antitumor activity against patient-derived DMG tumor cells compared with palbociclib. The results showed that YF-PRJ8-1011 could inhibit the growth of DMG cells in vitro and in vivo, penetrate the blood-brain barrier, and significantly inhibit the growth of DMG tumors and prolong the overall survival of mice. In addition, YF-PRJ8-1011 combined with radiotherapy also showed more significant inhibition of DMG xenograft tumor growth than radiotherapy alone.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Optics
Jing Bai, Xuan Liu, Cheng-Xian Ge, Zhen-Sen Wu, Xiao-Xiao Zhang
Summary: Interactions between collective multi-layered cells and an off-axis high-order Bessel beam (HOBB) were studied. The generalized Lorenz-Mie theory was used to derive the expansion of HOBB. Multiple scattering of collective multi-layered nanoparticles was obtained based on the additional theorem and considering the tangential continuous boundary conditions. The effectiveness of the present theory and codes was proven by comparing with simulations obtained from CST software. Numerical results regarding the effects of various parameters on the scattering of aggregated multi-layered particles were displayed, which may contribute to understanding the optical scattering characteristics of complex-shaped aggregated multi-layered biological cells and have important applications in manipulating multi-layered biological structures.
Article
Multidisciplinary Sciences
Zhenxing Wu, Jike Wang, Hongyan Du, Dejun Jiang, Yu Kang, Dan Li, Peichen Pan, Yafeng Deng, Dongsheng Cao, Chang-Yu Hsieh, Tingjun Hou
Summary: The authors propose a substructure mask explanation method to address the challenge of explaining the predictions made by neural networks in molecular property prediction. This method provides an interpretation consistent with the understanding of chemists. By applying this method, the authors elucidate how neural networks learn to predict various properties for small molecules and empower chemists to confidently analyze structure-activity relationships.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Meng Li, Hao Chen, Can Guo, Shangshu Qian, Hongpeng Li, Zhenzhen Wu, Chao Xing, Pan Xue, Shanqing Zhang
Summary: To address the issues of lithium-sulfur batteries, a dual interfacial engineering strategy is proposed. For the cathode, iminated polyaniline (iPANI) is used to achieve energetic and morphological engineering. For the anode, the iPANI@rGO-CNTs composite facilitates uniform deposition of lithium-ions, preventing dendrite growth. With the synergic effects of iPANI@rGO-CNTs nanoreactors, the prepared LSBs exhibit excellent rate capability and cycling life, potentially leading to commercialization.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Analytical
Man Wu, Yuhang Huang, Yaru Huang, Hua Wang, Min Li, Yang Zhou, Hui Zhao, Yuwei Lan, Zhenhua Wu, Chunping Jia, Shilun Feng, Jianlong Zhao
Summary: This study developed a microfluidic chip integrated with magnetic control technology for nucleic acid extraction, purification and amplification. The chip can automatically extract nucleic acid from multiple samples within 20 min and can be directly used for amplification. Furthermore, a multi-target detection chip was developed based on the droplet magnetic-controlled microfluidic chip, which successfully detected macrolides resistance mutations and mycoplasma pneumoniae gene in clinical samples, providing the possibility for future detection of multiple pathogens.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Zhenhua Wu, Xiaoli Zhu, Anjin Hong, Guanghui He, Zheng Wang, Qingyan Xu, Zhiyu Hu, Xiaobing Wu, Yuezhou Wang, Qiufang Chen, Xilin Zhao, Li Li, Xianming Deng
Summary: Inspired by the structural insights from the analysis of lefamulin's cocrystal structure with S. aureus ribosomes, a series of novel pleuromutilin derivatives were designed and synthesized. The study revealed that derivatives with urea in the meta position of phenylene sulfide showed optimal antibacterial activities. Among them, 21h exhibited the most potent activity against MRSA and clinical AMR Gram-positive bacteria, with low resistance frequency and prolonged Post-Antibiotic Effect. It also showed promising antibacterial activity in vivo, making it a potential lead for new antibiotics against Gram-positive pathogens, especially for AMR bacteria.
BIOORGANIC CHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Jessica Jein White, Jack Jon Hinsch, Zhenzhen Wu, Yuhui Tian, William W. Bennett, Yun Wang
Summary: Nanoscale zero-valent iron (nZVI) has high potential for remediating contaminated groundwater. Sulfidation is a promising approach to enhance nZVI's lifetime. Density functional theory (DFT) was used to study the impact of sulfidation on the hydrophobicity of Fe surfaces. The results show that surface hydrophobicity is mainly determined by the coverage of sulfur (S).
ADVANCED ENERGY AND SUSTAINABILITY RESEARCH
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
