Article
Medicine, Research & Experimental
Ming Chen, Pengqiang Zhong, Mengzhi Hong, Jinfeng Tan, Xuegao Yu, Hao Huang, Juan Ouyang, Xiaoping Lin, Peisong Chen
Summary: In this study, low coverage whole genome sequencing (LCWGS) was used to detect suspicious pelvic masses for ovarian cancer, showing high diagnostic value and complementarity with traditional diagnostic methods. The results suggest that LCWGS could be a promising tool for the identification of ovarian cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Zhe Xu, Si Cheng, Xin Qiu, Xiaoqi Wang, Qiuwen Hu, Yanfeng Shi, Yang Liu, Jinxi Lin, Jichao Tian, Yongfei Peng, Yong Jiang, Yadong Yang, Jianwei Ye, Yilong Wang, Xia Meng, Zixiao Li, Hao Li, Yongjun Wang
Summary: This study constructed an optimized pipeline and identified applicable fingerprint panels to address the sample tagging problem in whole genome bisulfite sequencing (WGBS) data. By using autosome-wide A/T polymorphic single nucleotide variants (SNVs), a fingerprint panel was designed and genotypes were called from the WGBS data. The capability to tag WGBS data was validated and the lower boundary for the number of fingerprint genetic variants needed for correct sample tagging was determined.
Article
Biochemistry & Molecular Biology
Ying Ni, Xudong Liu, Zemenu Mengistie Simeneh, Mengsu Yang, Runsheng Li
Summary: This study evaluates the application of the recently released R10.4 flow cell from Oxford Nanopore Technologies in human cancer genomics and epigenomic research. The results show that R10.4 performs better than R9.4.1 in terms of read accuracy, variant detection, methylation calling, and genome recovery rate. In addition, the study proposes a promising method for high-yield single-cell whole-genome amplification sequencing and provides a possible solution for filtering false positive sites using R10.4 data.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Peripheral Vascular Disease
Tanika N. Kelly, Xiao Sun, Karen Y. He, Michael R. Brown, Sarah A. Gagliano Taliun, Jacklyn N. Hellwege, Marguerite R. Irvin, Xuenan Mi, Jennifer A. Brody, Nora Franceschini, Xiuqing Guo, Shih-Jen Hwang, Paul S. de Vries, Yan Gao, Arden Moscati, Girish N. Nadkarni, Lisa R. Yanek, Tali Elfassy, Jennifer A. Smith, Ren-Hua Chung, Amber L. Beitelshees, Amit Patki, Stella Aslibekyan, Brandon M. Blobner, Juan M. Peralta, Themistocles L. Assimes, Walter R. Palmas, Chunyu Liu, Adam P. Bress, Zhijie Huang, Lewis C. Becker, Chii-Min Hwa, Jeffrey R. O'Connell, Jenna C. Carlson, Helen R. Warren, Sayantan Das, Ayush Giri, Lisa W. Martin, W. Craig Johnson, Ervin R. Fox, Erwin P. Bottinger, Alexander C. Razavi, Dhananjay Vaidya, Lee-Ming Chuang, Yen-Pei C. Chang, Take Naseri, Deepti Jain, Hyun Min Kang, Adriana M. Hung, Vinodh Srinivasasainagendra, Beverly M. Snively, Dongfeng Gu, May E. Montasser, Muagututi'a Sefuiva Reupena, Benjamin D. Heavner, Jonathon LeFaive, James E. Hixson, Kenneth M. Rice, Fei Fei Wang, Jonas B. Nielsen, Jianfeng Huang, Alyna T. Khan, Wei Zhou, Jovia L. Nierenberg, Cathy C. Laurie, Nicole D. Armstrong, Mengyao Shi, Yang Pan, Adrienne M. Stilp, Leslie Emery, Quenna Wong, Nicola L. Hawley, Ryan L. Minster, Joanne E. Curran, Patricia B. Munroe, Daniel E. Weeks, Kari E. North, Russell P. Tracy, Eimear E. Kenny, Daichi Shimbo, Aravinda Chakravarti, Stephen S. Rich, Alex P. Reiner, John Blangero, Susan Redline, Braxton D. Mitchell, Dabeeru C. Rao, Yii-Der Ida Chen, Sharon L. R. Kardia, Robert C. Kaplan, Rasika A. Mathias, Jiang He, Bruce M. Psaty, Myriam Fornage, Ruth J. F. Loos, Adolfo Correa, Eric Boerwinkle, Jerome I. Rotter, Charles Kooperberg, Todd L. Edwards, Goncalo R. Abecasis, Xiaofeng Zhu, Daniel Levy, Donna K. Arnett, Alanna C. Morrison
Summary: This study conducted a multiancestry whole-genome sequencing analysis to explore the associations between coding and noncoding variants and blood pressure. The study identified two significant blood pressure signals and nineteen suggestive signals, providing insights for future blood pressure sequencing studies, including the use of aggregate analyses and the need for larger, diverse samples and family studies.
Article
Health Care Sciences & Services
Nadin Younes, Najeeb Syed, Santosh K. Yadav, Mohammad Haris, Atiyeh M. Abdallah, Marawan Abu-Madi
Summary: Bone density disorders involve reduced bone mass density and strength, increasing the risk of sudden fractures. A study in Qatar analyzed genetic risk factors associated with low BMD in the population, identifying 15 variants significantly linked to total body BMD, 10 of which were new. Further research is needed to validate these findings and understand the functional effects of these variants on bone health.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Stella Huynh, Alison Cloutier, Simon Yung Wa Sin
Summary: Natural history collections provide valuable specimens for ecological and evolutionary studies. In this study, low-coverage whole genome sequencing was applied to historical and modern parrot specimens to analyze their phylogenomic relationships and population genomics. The results revealed the colonization and dispersal history of Agapornis parrots and identified parental origins of hybrid individuals.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2023)
Article
Biochemical Research Methods
Anthony F. Herzig, M. Ciullo, FranceGenRef Consortium, A-L Leutenegger, H. Perdry
Summary: This study presents a new method for estimating relatedness coefficients from genotype data, which provides accurate estimates for low-depth sequencing data and has advantages in terms of robustness and independence.
BMC BIOINFORMATICS
(2022)
Article
Infectious Diseases
Qiao Liu, Beibei Qiu, Guoli Li, Tingting Yang, Bilin Tao, Leonardo Martinez, Limei Zhu, Jianming Wang, Xuhua Mao, Wei Lu
Summary: This study in eastern China aimed to evaluate risk factors for tuberculosis recurrence and found that older age, previous tuberculosis treatment, and bilateral cavities were associated with higher risk of recurrence. Endogenous relapse was significantly more common than exogenous reinfection in the first 2 years post-treatment.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Microbiology
Yee Mey Seah, Mary K. K. Stewart, Daniel Hoogestraat, Molly Ryder, Brad T. T. Cookson, Stephen J. J. Salipante, Noah G. G. Hoffman
Summary: The identification and analysis of clinically relevant bacteria strains increasingly rely on whole-genome sequencing. However, the accuracy of variant callers for short-read sequences has seldom been validated against haploid genomes. In this study, a computational workflow was developed to introduce mutations into bacterial reference genomes and generate synthetic sequencing reads. The method was applied to three different bacterial strains, and several variant callers were evaluated using the synthetic reads as a truth set. The results showed that variant callers with high-quality soft-clipped reads and base mismatches had the highest precision and recall for identifying insertions and deletions.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Han Yang, Fei Gu, Lei Zhang, Xian-Sheng Hua
Summary: This article introduces a low-depth variant calling method called LDV-Caller, which is trained using a generative adversarial network to extract high-depth sequencing information from low-depth data. The results demonstrate that LDV-Caller achieves good performance and has the potential to analyze different species using low-depth sequencing data.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Linfeng Wu, Yuying Zhou, Yaoyao Guan, Rongyao Xiao, Jiaohao Cai, Weike Chen, Mengmeng Zheng, Kaiting Sun, Chao Chen, Guanli Huang, Xiaogang Zhang, Lijuan Zhai, Ziliang Qian, Shu-rong Shen
Summary: In this study, a risk stratification model based on molecular profiling of thyroid FNA washout DNA was developed to predict high-risk lymph node metastasis thyroid cancer preoperatively.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Guiju Zhou, Meizhen Zhou, Fanwei Zeng, Ningzhi Zhang, Yan Sun, Zhihong Qiao, Xueqin Guo, Shihao Zhou, Guojun Yun, Jiansheng Xie, Xiaodan Wang, Fengxia Liu, Chunna Fan, Yaoshen Wang, Zhonghai Fang, Zhongming Tian, Wentao Dai, Jun Sun, Zhiyu Peng, Lijie Song
Summary: This study evaluated the performance of PCR-free WGS for clinical diagnosis and investigated how experimental parameters affect variant detection. The results showed that PCR-free WGS had better depth of coverage, genotype quality, and sensitivity compared to PCR-based WGS. The coverage of disease-related genes and copy number variants was slightly better for PCR-free library preparation. The findings highlight the importance of understanding the range of sensitivity for different WGS methods in clinical variant detection.
Article
Multidisciplinary Sciences
Haifeng Qiu, Min Wang, Tingting Cao, Yun Feng, Ying Zhang, Ruixia Guo
Summary: The efficacy of UterCAD, a non-invasive method, for early detection of endometrial carcinoma (EC) was investigated. Through genetic sequencing analysis of tampon-collected specimens, UterCAD was able to distinguish EC from benign lesions with high sensitivity and specificity. This study is valuable in reducing the treatment burden on patients and avoiding unnecessary invasive procedures.
Article
Multidisciplinary Sciences
Brigitte Glanzmann, Tracey Jooste, Samira Ghoor, Richard Gordon, Rizwana Mia, Jun Mao, Hao Li, Patrick Charls, Craig Douman, Maritha J. Kotze, Armand V. Peeters, Glaudina Loots, Monika Esser, Caroline T. Tiemessen, Robert J. Wilkinson, Johan Louw, Glenda Gray, Robin M. Warren, Marlo Moeller, Craig Kinnear
Summary: The emergence of next generation sequencing has had a significant impact on genomic research, enabling South African researchers to access high quality data comparable to international standards at the South African Medical Research Council's Genomics Centre. This has enhanced the capacity of African researchers to sequence whole genomes and analyze data locally.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Hisashi Udagawa, Hiroyuki Ichida, Takanori Takeuchi, Tomoko Abe, Yoshimitsu Takakura
Summary: In this study, a whole-exome sequencing (WES) procedure was developed in tobacco to characterize EMS-induced mutations in a test population, revealing a high number of single nucleotide variants. The amount of mutations detected by WES was 93.5% of those detected by whole-genome sequencing, while requiring significantly less sequencing data, making it a cost-effective tool for high-throughput mutation identification in tobacco.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biology
Sabir Hussain, Abrar Hussain, Abdul Rehman, David George, Jun Li, Jehan Zeb, Adil Khan, Olivier Sparagano
Summary: The study compiled tick species data from different districts of Pakistan, showing the evolution of tick fauna over time. These findings help predict future economic risks and potential animal health losses associated with ticks.
Article
Biochemistry & Molecular Biology
Wan-Ting He, Xin Hou, Jin Zhao, Jiumeng Sun, Haijian He, Wei Si, Jing Wang, Zhiwen Jiang, Ziqing Yan, Gang Xing, Meng Lu, Marc A. Suchard, Xiang Ji, Wenjie Gong, Biao He, Jun Li, Philippe Lemey, Deyin Guo, Changchun Tu, Edward C. Holmes, Mang Shi, Shuo Su
Summary: This study conducted a transcriptomic analysis of game animals in China and identified numerous potentially high-risk viruses for humans and domestic animals. Civets were found to carry the highest number of these high-risk viruses. The study also revealed the transmission pathways of coronaviruses between different species.
Review
Microbiology
Sabir Hussain, Abrar Hussain, Muhammad Umair Aziz, Baolin Song, Jehan Zeb, David George, Jun Li, Olivier Sparagano
Summary: Zoonotic babesiosis poses a serious health risk in Asia, with the most prevalent species being Babesia microti in both animals and humans. Further investigations are needed to confirm the transmission routes of babesiosis in Asia.
Article
Biochemistry & Molecular Biology
Paul Lee, Rita Yim, Kai-Kei Miu, Sin-Hang Fung, Jason Jinyue Liao, Zhangting Wang, Jun Li, Yammy Yung, Hiu-Tung Chu, Pui-Kwan Yip, Emily Lee, Eric Tse, Yok-Lam Kwong, Harinder Gill
Summary: Epigenetic and epi-transcriptomic dysregulation of PTEN and MDM2 were associated with resistance to hypomethylating agents in MDS, highlighting the importance of understanding molecular mechanisms leading to HMA-resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Mathematical & Computational Biology
Shaochuan Li, Yuning Yang, Xin Wang, Jun Li, Jun Yu, Xiangtao Li, Ka-Chun Wong
Summary: In this study, a computational framework based on deep learning was proposed for colorectal cancer subtyping. The framework utilizes a minimalist feed-forward neural network to capture distinct molecular features in different cancer subtypes. The results demonstrate that the proposed method achieves superior performance compared to other algorithms and provides novel insights into cancer subtype identification and characterization mechanisms through gene ontology enrichment and pathology analysis.
Article
Microbiology
Lianwei Ye, Ning Dong, Wenguang Xiong, Jun Li, Runsheng Li, Heng Heng, Edward Wai Chi Chan, Sheng Chen
Summary: Metagenome assembly using a hybrid approach with Illumina and Nanopore platforms enhances efficiency of contig assembly, taxonomic binning, and genome construction. The hybrid metagenome assembly generates more complete plasmid sequences and AMR gene-encoding contigs compared to methods using Illumina reads alone. This technique also allows for obtaining high-quality metagenome bins, particularly from uncultured bacterial metagenome-assembled genomes.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Sabir Hussain, Nighat Perveen, Abrar Hussain, Baolin Song, Muhammad Umair Aziz, Jehan Zeb, Jun Li, David George, Alejandro Cabezas-Cruz, Olivier Sparagano
Summary: Ticks are important vectors of pathogens that affect human and animal health. They carry various pathogenic, commensal, and symbiotic microorganisms, which can influence tick physiology and ecology, as well as the development and transmission of tick-borne pathogens. Understanding the role of these endosymbionts is crucial for tick evolution and disease dynamics.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Dan Lin, Akos Kenez, Jessica A. A. McArt, Jun Li
Summary: This study proposed a transformer neural network to predict the probability of pregnancy loss in dairy cows based on continuous activity data. The model achieved high accuracy, recall, and specificity, outperforming traditional statistical learning and deep learning models. The results indicated the potential for early detection of pregnancy loss and improved reproductive efficiency in dairy farms.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Article
Gastroenterology & Hepatology
Dewei Ye, Jiating Huang, Jiaming Wu, Kang Xie, Xiang Gao, Kaixuan Yan, Pengfei Zhang, Ying Tao, Yun Li, Shufei Zang, Xianglu Rong, Jun Li, Jiao Guo
Summary: Gestational diabetes mellitus (GDM) is a condition characterized by high blood sugar and insulin resistance during the second or third trimester of pregnancy, which poses significant risks to both the mother and fetus. Through a study on a group of pregnant women with GDM and those with normal glucose tolerance (NGT), we discovered microbial and metabolic alterations associated with GDM. These findings provide insight into the mechanistic link between altered gut microbiota and GDM, and suggest that targeting the gut microbiota could be a promising intervention for GDM.
Article
Chemistry, Applied
Yat-Tin Chan, Jiating Huang, Ho-Ching Wong, Jun Li, Danyue Zhao
Summary: Polyphenols, present in plant-based foods, have various health benefits but are poorly absorbed. The colon, where most polyphenols are metabolized into more bioavailable compounds, plays a critical role in realizing the health benefits. This study explored the interactions between polyphenols and gut microbiota from different sources. By characterizing black raspberry polyphenols, anaerobic fermentations were conducted with microbiota from humans, rats, mice, and infants to compare the phenolic profile and microbiota composition. Bioinformatics analysis revealed unique interactions between polyphenols and gut microbiota, identifying potential bacterial species for producing bioactive and bioavailable phenolic metabolites.
Article
Multidisciplinary Sciences
Jing Wang, Yuan-fei Pan, Li-fen Yang, Wei-hong Yang, Kexin Lv, Chu-ming Luo, Juan Wang, Guo-peng Kuang, Wei-chen Wu, Qin-yu Gou, Gen-yang Xin, Bo Li, Huan-le Luo, Shoudeng Chen, Yue-long Shu, Deyin Guo, Zi-Hou Gao, Guodong Liang, Jun Li, Yao-qing Chen, Edward C. Holmes, Yun Feng, Mang Shi
Summary: The diversity and abundance of viruses in bats are not fully understood. This study analyzes individual bat viromes and reveals a high frequency of co-infection and spillover among bats. It also identifies viruses with the potential to infect humans or livestock.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Yong Zhang, Tingting Zheng, Da Ma, Peng Shi, Heping Zhang, Jun Li, Zhihong Sun
Summary: This study investigated the antihypertensive effect of Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 in high-fructose-treated mice. The results showed that these probiotics significantly reduced blood pressure and were associated with specific gut microbes and metabolic pathways. This study provides a potential mechanistic understanding of probiotics modulated blood pressure and their therapeutic potential in hypertension management.
Article
Biochemistry & Molecular Biology
Lijing Kang, Juanjuan Yi, Chi-Wai Lau, Lei He, Qinghua Chen, Suowen Xu, Jun Li, Yin Xia, Yuanting Zhang, Yu Huang, Li Wang
Summary: Hyperglycemia activates Yes-associated protein 1 (YAP) by suppressing AMPK activity, leading to obesity-associated endothelial dysfunction and inflammation. Metformin improves vascular dysfunction by activating AMPK and promoting YAP phosphorylation.
Article
Biochemistry & Molecular Biology
Emily Kwun Kwan Lo, Xiuwan Wang, Pui-Kei Lee, Ho-Ching Wong, Jetty Chung-Yung Lee, Carlos Gomez-Gallego, Danyue Zhao, Hani El-Nezami, Jun Li
Summary: This study found that Zearalenone (ZEA) intervention can promote the progression of colon cancer by enhancing the BEST4/AKT/ERK1/2 pathway, lowering circulatory amino acid concentrations, altering gut microbiota composition, and suppressing short chain fatty acids production through comprehensive analysis of xenograft mice.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Rui Cao, Masaki Takechi, Xiuwan Wang, Toshiko Furutera, Taro Nojiri, Daisuke Koyabu, Jun Li
Summary: The development of the inner ear involves the expression changes of numerous genes, and studying these changes is essential for a better understanding of inner ear development and elucidating the evolutionary trajectory of auditory development.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
