Article
Biochemistry & Molecular Biology
Jozsef Lenart, Attila Gere, Tim Causon, Stephan Hann, Mihaly Dernovics, Olga Nemeth, Attila Hegedus, Julia Halasz
Summary: This study aimed to identify metabolites playing crucial roles in sexual incompatibility reactions in apricot (Prunus armeniaca L.) using liquid chromatography coupled to time-of-flight mass spectrometry. The results showed significant differential compounds in self-compatible and self-incompatible apricot pistils, with a total explained variance of 89.55% in principal component analysis indicating high quality of differential expression analysis. The study suggested potential metabolites involved in the sexual incompatibility reactions, including polyketide-based macrolides and a hydroxy sphingosine derivative.
PLANT MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Sihao Hou, Tiantian Zhao, Zhen Yang, Lisong Liang, Wenxu Ma, Guixi Wang, Qinghua Ma
Summary: This study elucidated the mechanism of self-incompatibility and pollen-stigma interactions in Corylus plants through transcriptomic analysis, and identified key genes potentially involved in self-incompatibility. Additionally, the S-locus region was identified, laying the foundation for further analyses.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Wen He, Rui Xie, Yan Wang, Qing Chen, Hao Wang, Shaofeng Yang, Ya Luo, Yong Zhang, Haoru Tang, Frederick G. Gmitter, Xiaorong Wang
Summary: This study investigates the morphological, physiological, and anatomical differences between compatible and incompatible grafts, and explores the mechanisms underlying graft incompatibility. It reveals that hormonal balance and ABA biosynthesis genes play important roles in regulating graft incompatibility, and IAA and ABA are likely to be the inducers of stress-related gene expression. Excessive starch accumulation in leaves is observed in incompatible grafts. These findings provide new insights into citrus rootstock-scion interactions.
HORTICULTURE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Chie Kodera, Jeremy Just, Martine Da Rocha, Antoine Larrieu, Lucie Riglet, Jonathan Legrand, Frederique Rozier, Thierry Gaude, Isabelle Fobis-Loisy
Summary: This study utilized transcriptomic analysis based on genotypic differences in two Arabidopsis thaliana accessions to uncover the molecular signatures of compatible and incompatible pollinations at the male and female sides. Additionally, a tool was developed to predict gender-specific expression for genes without SNPs.
Article
Environmental Sciences
Chaoyang Fang, Zhenrao Cai, Adam Thomas Devlin, Xi Yan, Hao Chen, Xiangwei Zeng, Yang Xia, Qian Zhang
Summary: This study uses Nanchang, China as a case study to construct a multi-scenario ecosystem services protection scheme. The study finds that under a scenario that prioritizes the conservation of supporting and provisioning services, the management zones can be compatible with a large proportion of secondary services in the synergetic scenario. However, fewer secondary services are compatible under the trade-off scenario.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Review
Medicine, General & Internal
Georgios Floros, Ioanna Mylona
Summary: This narrative review examines the rationale and potential validity of an exclusion criterion for the diagnosis of gaming disorder, specifically focusing on the limitation of disordered gaming exclusively during an episode of elevated mood in bipolar disorder. The review critically examines the history of diagnostic criteria formulation and relevant studies, and offers suggestions for future research to better understand the exclusion criterion and the differential diagnosis of gaming disorder and pathological gambling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agronomy
Wiebke Kamper, Grant Thorp, Michelle Wirthensohn, Peter Brooks, Stephen J. Trueman
Summary: Breeding programs for horticultural tree crops mainly focus on improving productivity, pest and disease resistance, and crop quality. Pollination by different parents can affect almond kernel size and nutritional quality. Self-compatible cultivars may have a high percentage of kernels resulting from self-pollination, while different cross-pollen parents do not greatly impact kernel size or quality.
Article
Plant Sciences
Li Yang, Chuanji Zhao, Zetao Bai, Lingli Yang, M. Eric Schranz, Shengyi Liu, Klaas Bouwmeester
Summary: This study compared two Brassica napus lines with different resistance levels to black rot disease and evaluated the differential gene expression during infection. The resistant line showed a gradual increase in differentially expressed genes (DEGs), while the susceptible line displayed a steady amount of DEGs. Analysis of gene co-expression networks identified multiple defense-related genes and enriched pathways associated with defense.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zhouwen Wang, Meng Wang, Yi Ding, Tao Li, Senrong Jiang, Shaoling Kang, Shuangshuang Wei, Jun Xie, Jiaquan Huang, Wenbin Hu, Hongli Li, Hua Tang
Summary: Through transcriptome sequencing, we identified differentially expressed genes (DEGs) in the pitaya stigmas under different pollination types, especially at the late post-pollination stage. We also tentatively identified HuS-RNase2 as a candidate gynogenetic S gene in the pitaya GSI system based on the available transcriptome data and bioinformatics analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Agustin Saez, Ramiro Aguilar, Lorena Ashworth, Gabriela Gleiser, Carolina L. Morales, Anna Traveset, Marcelo A. Aizen
Summary: Modern agriculture relies heavily on pollinators, but the availability of honeybees is not able to meet the demand, and wild bees are declining. This can lead to reduced crop yield due to pollination limitation. A meta-analysis of published studies found that pollen supplementation increased crop yield by approximately 34%, indicating significant pollination limitation. Managed honeybees and self-compatibility were associated with lower pollination limitation. The findings suggest that current pollination management practices are inadequate and need to be transformed.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Guo-Tian Liu, Bian-Bian Wang, David Lecourieux, Mei-Jie Li, Ming-Bo Liu, Rui-Qi Liu, Bo-Xing Shang, Xiao Yin, Li-Jun Wang, Fatma Lecourieux, Yan Xu
Summary: Wild grapevines exhibit strong resistance to downy mildew pathogen P. viticola, with differentially expressed proteins related to photosynthesis, metabolism, and other processes. LB genotype shows fewer downregulated proteins in photosynthesis and more upregulated proteins in metabolism compared to PN genotype.
HORTICULTURE RESEARCH
(2021)
Article
Microbiology
Jingyu Zhu, Xue Tang, Yining Sun, Yan Li, Yajie Wang, Yusong Jiang, Huanhuan Shao, Bin Yong, Honghao Li, Xiang Tao
Summary: This study used untargeted metabolomics to investigate the changes in metabolites during the infection process of Phytophthora infestans in potato cultivars. The results showed that metabolic differences mainly emerged after 48 hours postinoculation. Comparisons between the resistant and susceptible cultivars identified metabolites related to resistance, including higher levels of salicylic acid in the resistant cultivar. These metabolites play crucial roles in cell wall thickening and have antibacterial and antifungal activities. This study reveals the metabolomic responses of potatoes to P. infestans and provides insights into the compatible and incompatible interactions between potatoes and P. infestans.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kaluhannadige R. E. Padmathilake, Wannakuwattewaduge Gerard Dilantha Fernando
Summary: This study evaluated the potential of the Rlm7 gene as resistance to Leptosphaeria maculans and its corresponding avirulence AvrLm7 gene. Differential gene expressions in compatible and incompatible interactions showed early recognition and control of the pathogen by the host through early activation of defense mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hannah Thomas, Lisa Van den Broeck, Ryan Spurney, Rosangela Sozzani, Margaret Frank
Summary: This study investigated the phenomenon of incompatibility in grafting, identifying the cellular basis and key anatomical events of delayed incompatibility through a model system. Core regulatory factors for grafting were inferred based on these findings, with SlWOX4 identified as a potential regulator of graft compatibility through functional analysis.
Article
Pediatrics
Caroline P. Lemoine, Katherine A. Brandt, Mahima Keswani, Riccardo Superina
Summary: ABO incompatible liver transplantation in infants with a high PELD score has excellent outcomes. Indications for ABO incompatible transplants should be liberalized to prevent deaths on the waiting list or deterioration of children with high PELD scores.
FRONTIERS IN PEDIATRICS
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.