Review
Endocrinology & Metabolism
David J. Ramsey, James T. Kwan, Arjun Sharma
Summary: Diabetic eye disease and diabetic foot ulcers (DFUs) are closely associated, both being complications of diabetes. Impaired wound healing, immune dysfunction, and peripheral vascular disease resulting from hyperglycemia and metabolic dysfunction in diabetes lead to tissue damage in both the lower extremities and the eyes. The coexistence of these diabetes-related complications necessitates comprehensive evaluations of both the eyes and feet, as well as optimizing diabetes management.
WORLD JOURNAL OF DIABETES
(2022)
Article
Medicine, General & Internal
Stephen M. Goldman, Susan L. Eskridge, Sarah R. Franco, Jason M. Souza, Scott M. Tintle, Thomas C. Dowd, Joseph Alderete, Benjamin K. Potter, Christopher L. Dearth
Summary: The aim of this study was to develop a data-driven approach for identifying limb salvage cases and studying their clinical outcomes. With the use of medical code data, a population of 2018 US Service members who underwent limb salvage was identified, representing 59.5% of the combat-related lower extremity trauma population. Comparison with expert opinion showed moderate agreement, and the approach demonstrated potential for future retrospective analyses of short- and long-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Ya-Chu Chang, Yu-Yao Huang, Shih-Yuan Hung, Jiun-Ting Yeh, Cheng-Wei Lin, I-Wen Chen, Hung-Hui Wei, Hui-Mei Yang, Chung-Huei Huang
Summary: This study investigated the validity of current wound classifications for the treatment prognosis of limb-threatening diabetic foot ulcers. The findings suggest that the Wagner classification and Texas stage, as well as clinical factors such as comorbidity with major adverse cardiac events, dialysis, and levels of C-reactive protein (CRP) and albumin, are independent predictors of prognosis. Additionally, levels of CRP and albumin appear to be valid predictors for subjects undergoing dialysis.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Stephen M. Goldman, Susan L. Eskridge, Sarah R. Franco, Christopher L. Dearth
Summary: This retrospective study provides insights into the demographics and injury characteristics of a group of US Service members with combat-related lower extremity limb salvage. The LS cohort exhibited more blast injuries and greater injury burden compared to their peers with non-threatened limb trauma. However, limb retention outcomes were not significantly affected by demographic factors or total injury burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
Summary: This study analyzed the clinical characteristics of diabetic inpatients with foot ulcers and explored the risk factors for lower extremity amputation. The study found that diabetic patients with amputation were older, had longer duration of diabetes, poor glycemic control, malnutrition, peripheral arterial disease, and severe foot ulcers with infection. A history of prior amputation, foot gangrene, and low ankle brachial index were independent predictors of lower extremity amputation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dermatology
Laurens Manning, Ivana Bastos Ferreira, Paul Gittings, Jonathan Hiew, Erica Ryan, Mendel Baba, Edward Raby, Keryln Carville, Paul E. Norman, Wendy Angela Davis, Fiona Wood, Emma Jane Hamilton, Jens Carsten Ritter
Summary: Spray-on skin treatment showed high rates of complete healing at 6 months in patients with large diabetes-related foot wounds, but was not significantly better than standard care. Lower body mass index and non-plantar wounds were the only patient- or wound-related factors associated with complete healing at 6 months.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Medicine, General & Internal
Alessia Scatena, Pasquale Petruzzi, Filippo Maioli, Francesca Lucaroni, Cristina Ambrosone, Giorgio Ventoruzzo, Francesco Liistro, Danilo Tacconi, Marianna Di Filippi, Nico Attempati, Leonardo Palombi, Leonardo Ercolini, Leonardo Bolognese
Summary: The study showed that treatment with autologous PBMNC implants in NO-CLI patients with DFUs significantly reduced amputation rate, improved survival, and promoted wound healing. Autologous PBMNC injection may effectively prevent amputations in patients with DFUs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Pam Chen, Nalini Campillo Vilorio, Ketan Dhatariya, William Jeffcoate, Ralf Lobmann, Caroline McIntosh, Alberto Piaggesi, John Steinberg, Prash Vas, Vijay Viswanathan, Stephanie Wu, Fran Game
Summary: The 2023 International Working Group on the Diabetic Foot (IWGDF) evidence-based guideline provides recommendations for wound healing interventions to promote healing of foot ulcers in persons with diabetes. These interventions, including newer technologies and multidisciplinary care, aim to improve healing rates and reduce costs. The guideline includes 29 separate recommendations for interventions to enhance wound healing of chronic diabetes-related foot ulcers. It is crucial to implement these recommendations widely and conduct further high-quality trials in this area.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Surgery
Heepeel Chang, Thomas S. Maldonado, Caron B. Rockman, Neal S. Cayne, Todd L. Berland, Michael E. Barfield, Glenn R. Jacobowitz, Mikel Sadek
Summary: This study aimed to evaluate whether closed incision negative pressure wound therapy (NPWT) could reduce the risk of complications in patients with peripheral vascular disease undergoing major lower extremity amputations compared to standard dressing. Results showed a higher tobacco use and more dirty wounds in the NPWT group, but a lower rate of wound complications.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Kaixu Yu, Ying Chen, Kehan Song, Fanxiu Xiong, Yahao Tian, Hanfeng Guan, Feng Li
Summary: Limb salvage surgery has positive impact on prognosis of patients with EBST sarcomas, but the extent of impact varies depending on the pathological subtype and stage.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Taira Kobayashi, Masaki Hamamoto, Takanobu Okazaki, Mayu Tomota, Misa Hasegawa, Shinya Takahashi
Summary: The study aims to assess the recommended limb outcomes after infrapopliteal vein bypass in cases with different WIfI and GLASS stages according to the 2019 Global Vascular Guidelines. The limb salvage rate, wound healing rate, and wound healing time were found to be associated with limb severity (WIfI stage), but not with anatomic complexity (GLASS stage).
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Koichi Morisaki, Daisuke Matsuda, Yutaka Matsubara, Shun Kurose, Shinichiro Yoshino, Go Kinoshita, Kenichi Honma, Terutoshi Yamaoka, Tadashi Furuyama, Tomoharu Yoshizumi
Summary: This study aimed to analyze the influence of the Global Anatomic Staging System (GLASS) and inframalleolar (IM) disease on the treatment outcomes of patients with chronic limb threatening ischaemia (CLTI) who undergo endovascular treatment (EVT). The study found that IM disease and GLASS stage were associated with major amputation, major adverse limb events (MALE), and wound healing, while GLASS stage was only associated with MALE.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Dermatology
Rebecca A. Burmeister, Christine Jarocki, Crystal M. Holmes, Gary M. Rothenberg, Michael E. Munson, Brian M. Schmidt
Summary: The study found that patients discharged to skilled nursing facilities after diabetes-related limb salvage surgery had longer healing time, increased risk of rehospitalization and subsequent major lower-extremity amputation on the same side, as well as a higher mortality rate compared to patients discharged home.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Dermatology
Sayumi Tsuchiya, Suriadi, Hiromi Sanada, Junko Sugama, Makoto Oe
Summary: A monitoring tool named DMIST was developed for assessing the wound-healing process of diabetic foot ulcers (DFUs). This study analyzed the relationship between DMIST items and DFU healing, finding that depth, maceration, and size were associated with DFU healing at 4 weeks from baseline.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
E. Sebastian Debus, Mark R. Nehler, Nicholas Govsyeyev, Rupert M. Bauersachs, Sonia S. Anand, Manesh R. Patel, Fabrizio Fanelli, Warren H. Capell, Taylor Brackin, Franz Hinterreiter, Dainis Krievins, Patrice Nault, Gabriele Piffaretti, Alexei Svetlikov, Nicole Jaeger, Connie N. Hess, Henrik H. Sillesen, Michael Conte, Joseph Mills, Eva Muehlhofer, Lloyd P. Haskell, Scott D. Berkowitz, William R. Hiatt, Marc P. Bonaca
Summary: The VOYAGER PAD trial demonstrated that rivaroxaban significantly reduced the risk of adverse events in patients who underwent surgical LER, although it increased the risk of bleeding.
Review
Oncology
Richard S. Whitlock, Kingsley Ebare, Lily S. Cheng, Douglas S. Fishman, Joseph L. Mills, HaiThuy N. Nguyen, Jed G. Nuchtern, Wenly Ruan, Valeria E. Smith, Kalyani A. Patel, Kevin E. Fisher, Sanjeev A. Vasudevan
Summary: This is the first reported case of pediatric pancreatic angiosarcoma with an activating KDR-internal tandem duplication. Literature on this disease process is very limited.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Surgery
Jessica M. Mayor, Ourania Preventza, Katharine McGinigle, Joseph L. Mills, Miguel Montero-Baker, Ramyar Gilani, Zachary Pallister, Jayer Chung
Summary: Women have been historically under-represented in vascular surgery and cardiovascular medicine trials, and the rate and change in representation of women in trials of common vascular diseases over the last decade is not completely understood. Participants in trials for common vascular diseases are generally not representative of the actual disease population, with women consistently being underrepresented.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Jorge A. Miranda, Jayer Chung, Joseph L. Mills
Summary: During the COVID-19 pandemic, patients with CLTI experienced increased rates of major and minor amputations. Vascular clinical volume decreased significantly during the pandemic, and further research is needed to improve strategies for treating this vulnerable population.
SEMINARS IN VASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Joep G. J. Wijnand, Devin Zarkowsky, Bian Wu, Steven T. W. van Haelst, Evert-Jan P. A. Vonken, Thomas A. Sorrentino, Zachary Pallister, Jayer Chung, Joseph L. Mills, Martin Teraa, Marianne C. Verhaar, Gert J. de Borst, Michael S. Conte
Summary: The Global Vascular Guidelines in 2020 aim to improve decision-making in Chronic Limb-Threatening Ischemia by providing an evidence-based revascularization framework. The Global Limb Anatomic Staging System (GLASS) serves to estimate the success of lower extremity arterial revascularization based on the extent and distribution of atherosclerotic lesions. The study suggests that a stepwise component scoring provides acceptable agreement for GLASS and lays a solid foundation for further validation studies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Richard S. Whitlock, Steven C. Mehl, Daniel C. Chelius, John C. Koshy, Joseph L. Mills, Julina Ongkasuwan, Susan L. McGovern, M. Fatih Okcu, Bindi Naik-Mathuria
Summary: MRT, highly aggressive with poor prognosis, can occur in various locations; cervical rhabdoid tumors are extremely rare. Successful surgical resection led to over one year survival in this case.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Article
Surgery
Jorge Miranda, Deepa Dongarwar, Hamisu M. Salihu, Miguel Montero-Baker, Ramyar Gilani, Zachary S. Pallister, Joseph L. Mills, Jayer Chung
Summary: The study found that rates of iatrogenic vascular injuries (IaVI's) increased among the top ten most frequently performed inpatient procedures in the United States from 2008 to 2015. Females, the elderly, and Hispanics were more likely to experience IaVI's. Overall, IaVI's independently increased the adjusted odds of mortality by 25%, with Blacks facing a 50% elevated risk compared to Non-Hispanic Whites.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Surgery
Neal R. Barshes, Deeksha Bidare, Panos Kougias, Joseph L. Mills, Scott A. LeMaire
Summary: This study found that AAA screening has lower diagnostic rates among minority populations and suggests the need for various targeted strategies to address this disparity.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Edward D. Gifford, Nicolas J. Mouawad, Kathryn E. Bowser, Ruth L. Bush, Venita Chandra, Dawn M. Coleman, Elizabeth Genovese, Daniel K. Han, Misty D. Humphries, Joseph L. Mills, Erica L. Mitchell, Carla C. Moreira, Reginald Nkansah, Jeffrey J. Siracuse, Jordan R. Stern, Dongjin Suh, Lauren West-Livingston
Summary: The use of social media in medicine has shown potential to improve networking among healthcare professionals, disseminate research, provide up-to-date information, and engage medical students and the public. It is important to uphold patient privacy, encourage appropriate consent and imagery use, disclose conflicts of interest, and prevent negative interactions online. The Society for Vascular Surgery is dedicated to promoting honest, well-informed, and accurate use of social media content in the medical field.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Karen Woo, Jeffrey J. Siracuse, Kyle Klingbeil, Larry W. Kraiss, Nicholas H. Osborne, Niten Singh, Tze-Woei Tan, Shipra Arya, Subhash Banerjee, Marc P. Bonaca, Thomas Brothers, Michael S. Conte, David L. Dawson, Young Erben, Benjamin M. Lerner, Judith C. Lin, Joseph L. Mills, Derek Mittleider, Deepak G. Nair, Leigh Ann O'Banion, Robert B. Patterson, Matthew J. Scheidt, Jessica P. Simons
Summary: The Society for Vascular Surgery created appropriate use criteria (AUC) for managing intermittent claudication using a validated method that combines evidence from medical literature with expert opinion. These criteria serve as a framework for shared decision-making between patients and clinicians. It is important to note that these criteria are not absolute and should be periodically reviewed for relevance.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Mahmood Kabeil, Max Wohlauer, Mario D'Oria, Vipul Khetarpaul, Riley Gillette, Ethan Moore, Kathryn Colborn, Robert F. Cuff, Leigh Ann O'Banion, Issam Koleilat, Faisal Aziz, Nicolas J. Mouawad
Summary: The study found that during the COVID-19 pandemic, delays in carotid artery operations were primarily due to hospital policies, with most patients not deteriorating or requiring emergency surgery during the delay.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Joseph Mills, Robert Hinchliffe, David Russell, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: Early diagnosis and ongoing monitoring and treatment of peripheral artery disease (PAD) is crucial for reducing the risk of foot ulcer development, non-healing of wounds, infection, amputation, and cardiovascular complications in patients with diabetes. Various non-invasive bedside tests are available for diagnosing PAD, but the most accurate test and its reliability for ongoing monitoring are still uncertain. This systematic review aimed to determine the diagnostic accuracy of non-invasive bedside tests for identifying PAD and their reliability in adults with diabetes. The review included 40 studies on diagnostic accuracy and 7 studies on reliability. Ankle-brachial index (ABI) was the most investigated test. The review found that an ABI <0.9 increases the likelihood of disease, while an ABI within the normal range (≥0.90 and <1.3) does not exclude PAD. Toe-brachial index (TBI) and Doppler waveforms in the pedal arteries were also associated with PAD presence. Several bedside tests showed acceptable reliability, but the margin of error was wide. No single or combination of bedside tests demonstrated superior diagnostic accuracy for PAD in patients with diabetes. However, an ABI of 1.3, TBI <0.70, and absent or monophasic pedal Doppler waveforms can help identify the presence of disease.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Robert Hinchliffe, Joseph Mills, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Russell David, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: This systematic review aimed to determine the performance of non-invasive bedside tests for predicting the outcomes of DFU healing, minor amputation, and major amputation in people with diabetes and DFU or gangrene. The results showed that a toe pressure of ≥30 mmHg, TcPO2 of ≥25 mmHg, and skin perfusion pressure of ≥40 mmHg were associated with a moderate to large increase in the likelihood of DFU healing. However, there is limited research on the prognostic capacity of bedside testing for healing post-minor amputation or major amputation in people with DFU. Current evidence suggests that an ABI <0.4 may be associated with a large increase in the risk of major amputation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. Mcginigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David Russell, Jos C. van den Berg, Maarit Venermo, Nicolaas Schaper
Summary: Diabetes-related foot complications, including peripheral artery disease (PAD), are increasing globally and causing major and minor amputations. The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines since 1999. This updated guideline, developed in collaboration with other vascular surgery societies, provides recommendations for diagnosing PAD, estimating healing and amputation outcomes, and treating PAD in individuals with diabetes mellitus and foot ulcers.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Dermatology
Hailey R. Donnelly, Erin D. Clarke, Clare E. Collins, Rebecca A. Collins, David G. Armstrong, Joseph L. Mills, Peta E. Tehan
Summary: The inaugural expert consensus and guidance for Nutrition Interventions in Adults with Diabetic Foot Ulcers (DFU) have provided important guidance for clinicians and revealed inadequacies in the dietary intake of individuals with DFU. Future guidelines should consider evidence-based recommendations and include all essential nutrients for wound healing in DFU.
INTERNATIONAL WOUND JOURNAL
(2023)
