Article
Immunology
Glautemberg de Almeida Viana, Mac Dionys Rodrigues da Costa, Mateus Edson da Silva, Bruna Ribeiro Duque, Erlania Alves de Siqueira, Alice Maria Costa Martins, Renata de Sousa Alves, Ramon Roseo Paula Pessao Bezerra de Menezes, Maria Goretti Rodrigues de Queiroz, Tiago Lima Sampaio
Summary: COVID-19 is an inflammatory disease associated with cardiovascular risk, and it may cause changes in lipoprotein metabolism. This study evaluated the association of IL-18 levels and its SNP rs187238 with changes in lipoprotein profiles in COVID-19 outpatients. The results showed that COVID-19 patients had lower levels of total cholesterol and HDL-c, but no difference in IL-18 levels. IL-18 was negatively correlated with HDL-c and positively correlated with the Apo B/Apo A-I ratio. In conclusion, IL-18 levels and its SNP rs187238 were associated with decreased HDL-c and Apo A-I in COVID-19 outpatients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Guang-Bin Zhao, Lei Miao, Mengge Wang, Jia-Hui Yuan, Lan-Hai Wei, Yao-Sen Feng, Jie Zhao, Ke-Lai Kang, Chi Zhang, An-Quan Ji, Guanglin He, Le Wang
Summary: This article introduces a 639-plex panel including 633 Y-SNPs and 6 Y-Insertion/deletions for paternal studies and forensic applications in Chinese populations. The panel shows high concordance, accuracy, and reproducibility, and can represent the genetic diversity and complex population structures of the Chinese Y-chromosome.
Article
Multidisciplinary Sciences
Jonas Schmidt, Sandro Berghaus, Frithjof Blessing, Holger Herbeck, Josef Blessing, Peter Schierack, Stefan Rodiger, Dirk Roggenbuck, Folker Wenzel
Summary: Nanopore sequencing has great potential for clinical diagnostics, but further validation and certification are required.
Article
Food Science & Technology
Huan Zhou, Junhui Zhang, Yanna Shao, Juan Wang, Wenxing Xu, Yang Liu, Shubo Yu, Qinghua Ye, Rui Pang, Shi Wu, Qihui Gu, Liang Xue, Jumei Zhang, Hongye Li, Qingping Wu, Yu Ding
Summary: The study developed a rapid identification method based on nucleotide and genome analysis, successfully distinguishing Bacillus cereus and Bacillus thuringiensis. By using the core molecular target ispD, a high-resolution melting method was developed. This method has high sensitivity and specificity in detection.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Chao Zhang, Tingting Zheng, Qian Ma, Linlin Yang, Mingzhi Zhang, Junyan Wang, Xiaoyan Teng, Yanyan Miao, Hsiao-chu Lin, Yang Yang, Da Han
Summary: Analyzing SNP combinations is crucial for research and clinical applications. DNA-based molecular computing has shown promise in sensing and analyzing molecular information. This study presents a DNA computational scheme that can sense multiple SNPs and perform logical analysis for clinical outcomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Veterinary Sciences
Ling Yang, Jiachen Bai, Zhihua Ju, Qiang Jiang, Jinpeng Wang, Yaping Gao, Yaran Zhang, Xiaochao Wei, Jinming Huang
Summary: This study identified an association between the APOA1 gene and ketosis in high-yielding dairy cows. A novel SNP (g.-572 A > G) in the core promoter region of the APOA1 gene was found, which may serve as a genetic marker for ketosis prevention. Furthermore, lower concentrations of blood beta-hydroxybutyrate were observed in cows with the genotype GG compared to cows with genotypes AA and AG.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Biochemical Research Methods
Limei Zhang, Dan Liu, Baolin Li, Jingling Xie, Jinbo Liu, Zhang Zhang
Summary: In this study, a SNP analysis method based on probe-mediated melting curves was developed for the detection of ALDH2 gene polymorphisms. The method is efficient and cost-effective, with 100% concordance with direct sequencing results. Furthermore, this platform was extended to the detection of polymorphisms related to folate metabolism.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Qidi He, Ou Hu, Meng Chen, Zhixian Liang, Lushan Liang, Zuanguang Chen
Summary: A novel AS-PCR method for multiple SNP genotyping in a single run was proposed, which showed high sensitivity and low cost. It is suitable for genotyping multiple genes and has great potential for wide applications in personalized health management.
ANALYTICA CHIMICA ACTA
(2022)
Article
Genetics & Heredity
Sang-Min Yeo, Jeongeui Hong, Mohammad Rashed Hossain, Hee-Jeong Jung, Phillip Choe, Ill-Sup Nou
Summary: In this study, QTLs associated with bacterial fruit blotch (BFB) resistance in watermelon were identified and high-resolution melting (HRM) markers related to resistant/susceptible alleles were developed. The efficacy of these markers was validated in another population, and a key locus containing candidate genes for BFB resistance was identified.
Article
Chemistry, Multidisciplinary
Duo Chen, Wanting Huang, Yun Zhang, Bo Chen, Jie Tan, Quan Yuan, Yanbing Yang
Summary: Mass pathogen screening is crucial in preventing outbreaks and transmission of infectious diseases. A CRISPR-based Amplification-free Viral RNA Electrical Detection platform (CAVRED) is developed for rapid identification of SARS-CoV-2 variants. CAVRED utilizes CRISPR RNA assays to amplify the CRISPR-Cas system's ability to detect single-nucleotide differences between mutant and wild RNA genomes. With highly sensitive field-effect transistor biosensors, CAVRED can detect SARS-CoV-2 virus genome as low as 1 cp mu L-1 within 20 mins without amplification, offering a comparable detection limit to real-time quantitative polymerase chain reaction. An 8-in-1 CAVRED array achieves 95.0% accuracy in rapid identification of 40 simulated throat swab samples of SARS-CoV-2 variants, promising its application in rapid and large-scale epidemic screening.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Forestry
Liliana E. Garcia-Valencia, Jocelyn Perez-Garcia, Miguel Angel Vallejo-Reyna, Roberto Reynoso-Santos, Jesus Vargas-Hernandez, Florencia Garcia-Campusano
Summary: The study evaluated the utility of real-time PCR coupled with high-resolution melting (HRM) for identifying different varieties within the Pseudostrobus complex. The results showed that specific gene loci could successfully discriminate among different varieties, and also revealed the impact of geography on allele distribution and species hybridization.
Article
Genetics & Heredity
Mahla Sattarzadeh Bardsiri, Shahrzad Zehtab, Najibe Karami, Alireza Farsinejad, Mohsen Ehsan, Ahmad Fatemi
Summary: This study reveals a significant association between the CT genotype and T allele at rs3731249 (CDKN2A) and an increased risk of childhood acute lymphoblastic leukemia (ALL).
BMC MEDICAL GENOMICS
(2022)
Article
Agronomy
Avi Raizada, J. Souframanien
Summary: The study analyzed the genetic relatedness among 27 blackgram genotypes using 19 genic-single nucleotide polymorphisms (SNPs) through high resolution melting (HRM) analysis. The results indicated a close relationship between most genotypes and cultivated blackgram, while also identifying SNP markers related to wild accessions. The findings are crucial for developing elite varieties and designing appropriate breeding strategies through exploitation of important agronomic alleles.
GENETIC RESOURCES AND CROP EVOLUTION
(2021)
Article
Chemistry, Analytical
Zhang Zhang, Luhao Guan, Juan Yao, Lijia Li, Chunfang Liu, Yongcan Guo, Guoming Xie
Summary: In this study, a closed-tube, dual-labeled RNA-modified probes and RNase H II-assisted real-time LAMP (RART-LAMP) method was proposed for SNP genotyping. This method allows for rapid and accurate nucleic acid analysis in resource-limited settings, and can be applied to various sample types including blood, saliva, and swabs.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bhanu Sharma, Shabab Angurana, Amrita Bhat, Sonali Verma, Divya Bakshi, Ghulam Rasool Bhat, Rajeshwer Singh Jamwal, Asif Amin, Raies Ahmed Qadri, Ruchi Shah, Rakesh Kumar
Summary: This study conducted SNP genotyping in the Jammu and Kashmir population to investigate the association with colorectal cancer, identifying 5 SNPs significantly correlated with the disease. The results suggest that MassARRAY(TM) technology could be valuable in understanding genetic complexity.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Oncology
Stephen Osasan, Mingyong Zhang, Fan Shen, Paulose J. Paul, Sujata Persad, Consolato Sergi
ANTICANCER RESEARCH
(2016)
Article
Urology & Nephrology
Wang Zheng, Fan Shen, Ruikun Hu, Birbickram Roy, JungWoo Yang, Qian Wang, Fan Zhang, Jennifer C. King, Consolato Sergi, Song-Mei Liu, Emmanuelle Cordat, Jingfeng Tang, Ying Cao, Declan Ali, Xing-Zhen Chen
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Review
Nutrition & Dietetics
Mingyong Zhang, Fan Shen, Anna Petryk, Jingfeng Tang, Xingzhen Chen, Consolato Sergi
Article
Multidisciplinary Sciences
Ying Yang, Wei Huang, Jing-Tao Huang, Fan Shen, Jun Xiong, Er-Feng Yuan, Shan-shan Qin, Ming Zhang, Yu-Qi Feng, Bi-Feng Yuan, Song-Mei Liu
SCIENTIFIC REPORTS
(2016)
Review
Gastroenterology & Hepatology
Consolato Sergi, Fan Shen, Gerd Bouma
WORLD JOURNAL OF GASTROENTEROLOGY
(2017)
Editorial Material
Pathology
Fan Shen, Consolato Sergi, Hui-lung Sun
JOURNAL OF MOLECULAR DIAGNOSTICS
(2018)
Article
Endocrinology & Metabolism
Ying Yang, Fan Shen, Wei Huang, Shanshan Qin, Jing-Tao Huang, Consolato Sergi, Bi-Feng Yuan, Song-Mei Liu
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Consolato Sergi, Fan Shen, Song-Mei Liu
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Oncology
Li Jin, Fan Shen, Michael Weinfeld, Consolato Sergi
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Eugeniu Jantuan, Brian Chiu, Bonnie Chiu, Fan Shen, Gavin Y. Oudit, Consolato Sergi
Summary: The study suggests that cardiac myxomas can upregulate autophagy to create a favorable environment for EBV-driven oncogenesis, with a dichotomous separation into low and high inflammatory grades in these tumors. This research provides new insights into the tumor microenvironment and molecular pathways involved in cardiac myxomas, warranting further investigation.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biology
Mervin Burnett, Vito Rodolico, Fan Shen, Roger Leng, Mingyong Zhang, David D. Eisenstat, Consolato Sergi
Summary: Researchers analyzed the pathways of miRNAs in osteosarcoma using bioinformatics tools and found some miRNAs associated with good response to chemotherapy in patients. These miRNAs appear to be involved in the TP53 network.
Article
Oncology
Mervin Burnett, Yasser Abuetabh, Ania Wronski, Fan Shen, Sujata Persad, Roger Leng, David D. Eisenstat, Consolato Sergi
Review
Medicine, Research & Experimental
Consolato Sergi, Fan Shen, David W. Lim, Weiyong Liu, Mingyong Zhang, Brian Chiu, Vijay Anand, Ziyong Sun
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Review
Medical Laboratory Technology
Tim Kong, Joseph Feulefack, Kim Ruether, Fan Shen, Wang Zheng, Xing-Zhen Chen, Consolato Sergi
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2017)
Review
Medical Laboratory Technology
Bonnie Chiu, Eugeniu Jantuan, Fan Shen, Brian Chiu, Consolato Sergi
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2017)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.